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公开(公告)号：US4448352A
公开(公告)日：1984-05-15
申请号：US358251
申请日：1982-03-15
Applicant: Carl C. Jacobson, Jr. , Mark C. Manning
Inventor： Carl C. Jacobson, Jr. , Mark C. Manning
CPC classification number: E01C19/176 , B05B9/00 , E01C19/174
Abstract: A manually manipulatable spray mechanism for connection to a supply apparatus having a source of molten asphalt under pressure for applying a sprayed coating of molten asphalt on selected areas of a paved surface. The spray mechanism is configured so that its asphalt spray pattern may be adjusted to suit the job being accomplished, and, to provide for recirculatingly returning the molten asphalt to the supply apparatus when the spray mechanism is in the inoperative or stand by state.
Abstract translation: 一种可手动操作的喷射机构，用于连接到具有在压力下的熔融沥青源的供应装置，用于将铺设的熔融沥青喷涂在铺设的表面的选定区域上。 喷雾机构被构造成使得其沥青喷雾图案可以被调节以适合于完成的工作，并且当喷雾机构处于不工作状态或待机状态时，提供将熔融沥青循环返回到供应设备。
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公开(公告)号：US4390304A
公开(公告)日：1983-06-28
申请号：US365198
申请日：1982-04-05
Applicant: Carl C. Jacobson, Jr. , Mark C. Manning
Inventor： Carl C. Jacobson, Jr. , Mark C. Manning
CPC classification number: E01C19/482
Abstract: A manually manipulatable applicator mechanism for applying and embedding crushed rocks on selected areas of a paved surface. The mechanism includes a first gate structure by which an operator can vary the width dimension of the pattern of applied rocks and a second gate structure for controlling the quantity of rocks applied by the mechanism and thus controlling the thickness of the pattern of applied rocks.
Abstract translation: 一种可手动操作的施加器机构，用于在被铺设的表面的选定区域上施加和嵌入碎石。 该机构包括第一栅极结构，操作者可以通过该第一栅极结构改变所施加的岩石的图案的宽度尺寸，以及用于控制由该机构施加的岩石的量的第二栅极结构，从而控制施加的岩石的图案的厚度。
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公开(公告)号：US5770559A
公开(公告)日：1998-06-23
申请号：US473008
申请日：1995-06-06
Applicant: Mark C. Manning , Theodore W. Randolph , Eli Shefter , Richard F. Falk, III
Inventor： Mark C. Manning , Theodore W. Randolph , Eli Shefter , Richard F. Falk, III
IPC: A61K9/00 , A61K9/16 , A61K9/51 , A61K38/04 , A61K38/22 , A61K38/28 , A61K38/57 , A61K47/48 , B01F3/00 , C07K1/30 , A61K38/00 , A23J1/00
CPC classification number: A61K9/145 , A61K38/05 , A61K38/09 , A61K38/27 , A61K38/28 , A61K38/57 , A61K47/4803 , A61K47/48792 , A61K47/48876 , A61K9/0024 , A61K9/0078 , A61K9/08 , A61K9/1647 , A61K9/5123 , A61K9/5153 , B01F3/0092 , C07K1/30 , B01F2003/0064 , Y02P20/544
Abstract: Provided is a method for preparing a true, homogeneous solution of a pharmaceutical substance dissolved in an organic solvent in which the pharmaceutical substance is not normally soluble. Solubilization is obtained by forming a hydrophobic ion pair complex involving the pharmaceutical substance and an amphiphilic material. The resulting organic solution may be further processed to prepare pharmaceutical powders. A biodegradable polymer may be co-dissolved with the pharmaceutical substance and the amphiphilic material and may be incorporated into a pharmaceutical powder. A preferred method for preparing pharmaceutical powders is to subject the organic solution to gas antisolvent precipitation using a supercritical gas antisolvent such as carbon dioxide. Also provided is a method for making hollow particles having a fiber-like shape which would provide enhanced retention time in the stomach if ingested by a human or animal host.
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4.发明授权
公开(公告)号：US5981474A
公开(公告)日：1999-11-09
申请号：US98791
申请日：1998-06-17
Applicant: Mark C. Manning , Theodore W. Randolph , Eli Shefter , Richard F. Falk, III
Inventor： Mark C. Manning , Theodore W. Randolph , Eli Shefter , Richard F. Falk, III
IPC: A61K9/00 , A61K9/16 , A61K9/51 , A61K38/04 , A61K38/22 , A61K38/28 , A61K38/57 , A61K47/48 , B01F3/00 , C07K1/30 , A61K38/00 , A23J1/00
CPC classification number: A61K9/145 , A61K38/05 , A61K38/09 , A61K38/27 , A61K38/28 , A61K38/57 , A61K47/4803 , A61K47/48792 , A61K47/48876 , A61K9/0024 , A61K9/0078 , A61K9/08 , A61K9/1647 , A61K9/5123 , A61K9/5153 , B01F3/0092 , C07K1/30 , B01F2003/0064 , Y02P20/544
Abstract: Provided is a method for preparing a true, homogeneous solution of a pharmaceutical substance dissolved in an organic solvent in which the pharmaceutical substance is not normally soluble. Solubilization is obtained by forming a hydrophobic ion pair complex involving the pharmaceutical substance and an amphiphilic material. The resulting organic solution may be further processed to prepare pharmaceutical powders. A biodegradable polymer may be co-dissolved with the pharmaceutical substance and the amphiphilic material and may be incorporated into a pharmaceutical powder. A preferred method for preparing pharmaceutical powders is to subject the organic solution to gas antisolvent precipitation using a supercritical gas antisolvent such as carbon dioxide. Also provided is a method for making hollow particles having a fiber-like shape which would provide enhanced retention time in the stomach if ingested by a human or animal host.
Abstract translation: 提供了制备溶解在药物通常不溶于其中的有机溶剂中的药物的真实均匀溶液的方法。 通过形成涉及药物物质和两亲性物质的疏水性离子对络合物来获得溶解。 所得到的有机溶液可以进一步加工以制备药物粉末。 可生物降解的聚合物可以与药物物质和两亲物质共溶，并且可以并入药物粉末中。 用于制备药物粉末的优选方法是使用超临界气体反溶剂如二氧化碳对有机溶液进行气体反溶剂沉淀。 还提供了一种制备具有纤维状形状的中空颗粒的方法，其将在人或动物宿主摄入时提供增强的胃中的停留时间。
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公开(公告)号：US20200093885A1
公开(公告)日：2020-03-26
申请号：US16576961
申请日：2019-09-20
Applicant: Christopher BRYANT , Mark C. Manning , Ryan E. Holcomb
Inventor： Christopher BRYANT , Mark C. Manning , Ryan E. Holcomb
IPC: A61K38/095 , A61K47/38 , A61K9/08 , A61K47/22 , A61K47/26
Abstract: The present disclosure includes a method of making an improved carbetocin drug product. The disclosed method for making an improved carbetocin drug product comprises agitating a carbetocin preparation containing an aqueous solution of carbetocin and one or more excipients for a period of time to initiate the formation of aggregate-forming solids and filtering off the aggregates that form before further processing the remaining carbetocin into a final drug product. The present disclosure also relates to an improved carbetocin drug product, wherein the drug product is substantially free of aggregate-forming solids. The disclosed carbetocin drug product can be used for the treatment of a neurodevelopmental disorder, such as Präder-Willi syndrome. Additionally, the disclosed carbetocin drug product shows content uniformity of carbetocin over long periods of time before and after one or more freeze/thaw cycles, provides enhanced convenience and patient compliance, and/or are highly concentrated.
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公开(公告)号：US5537947A
公开(公告)日：1996-07-23
申请号：US327657
申请日：1994-10-24
Applicant: John R. Couture , Alan T. Hudson , Michael J. Balboni , Mark C. Manning , Patrick J. Kelly , Brian J. Gallagher
Inventor： John R. Couture , Alan T. Hudson , Michael J. Balboni , Mark C. Manning , Patrick J. Kelly , Brian J. Gallagher
CPC classification number: B63B22/003
Abstract: An expendable underwater vehicle for use in training naval forces in anti-submarine warfare in ocean waters, including shallow waters, is between about three to five feet in length and about five inches in diameter, and it includes various improvements which make successful operations in shallow ocean waters, and improved operation in all ocean waters, possible. The improvements include a one-piece nose cup which allows the expendable underwater vehicle to be air launched into shallow water, a scuttle plug which allows water to fill the expendable underwater vehicle after the vehicle is expended and drops to the bottom of the ocean, and rudders and elevators of increased surface area which improve controllability of the vehicle in the water.
Abstract translation: 在海洋水域，包括浅水区，用于训练海军在海上作战的消耗性水下航行器，长度约3至5英尺，直径约5英寸，包括各种改进，使浅层成功运行 海洋水域，改善所有海洋水域的运作。 这些改进包括一个单件鼻杯，其允许将一次性水下航行器空气发射到浅水中，一个水壶塞，其允许水在车辆消耗并落到海底之后填充消耗性水下航行器，并且 方向舵和提高表面积的电梯，提高车辆在水中的可控性。
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公开(公告)号：US5490473A
公开(公告)日：1996-02-13
申请号：US408060
申请日：1995-03-21
Applicant: Raymond A. Chace, Jr. , Mark C. Manning
Inventor： Raymond A. Chace, Jr. , Mark C. Manning
Abstract: An expendable underwater vehicle for use in training naval forces in anti-submarine warfare in ocean waters is between about three to five feet in length and about five inches in diameter, and it includes various improvements which make successful operation in the ocean waters possible. The improvements include an in-water variable speed feature, a variable tonal levels feature, an autonomous evasion feature, and a high-power integrated pinger feature. One or more of these features can be combined to provide an extremely effective and versatile expendable underwater training vehicle.
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公开(公告)号：US4159877A
公开(公告)日：1979-07-03
申请号：US894892
申请日：1978-04-10
Applicant: Carl C. Jacobson , Mark C. Manning , Francis K. Hill
Inventor： Carl C. Jacobson , Mark C. Manning , Francis K. Hill
CPC classification number: E01C19/45 , E01C19/176 , E01C23/0973
Abstract: A self-contained mechanism for the preparation handling and application of liquified materials such as coating compounds, joint sealers, crack fillers, waterproofing compounds and the like, is provided with an especially configured materials tank having primary and secondary materials heating devices and a unique engine driven hydraulic system which allows reversible and variable speed operation of the materials mixing, delivery, and cleanout devices and systems.
Abstract translation: 具有独特的机构，用于处理和应用液化材料如涂料化合物，接缝密封剂，裂缝填料，防水化合物等的制备处理和应用，具有特殊配置的材料罐，其具有初级和次级材料加热装置和独特的发动机 驱动液压系统，允许材料混合，输送和清洁装置和系统的可逆和可变速度运行。
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公开(公告)号：US06613358B2
公开(公告)日：2003-09-02
申请号：US09877330
申请日：2001-06-07
Applicant: Theodore W. Randolph , Mark C. Manning , Richard F. Falk
Inventor： Theodore W. Randolph , Mark C. Manning , Richard F. Falk
IPC: A61K916
CPC classification number: A61K9/1694 , A61K47/541 , A61K47/554 , Y10S514/937 , Y10S514/951
Abstract: Provided is a sustained release composition for sustained release of a pharmaceutical substance. The composition includes a biocompatible polymer that is highly amorphous and a pharmaceutical substance in a hydrophobic ion complex with an amphiphilic material. Also provided is a compressed antisolvent method for manufacturing the composition, various product forms incorporating the composition and various uses for the composition.
Abstract translation: 提供用于药物物质的持续释放的持续释放组合物。 该组合物包括高度无定形的生物相容性聚合物和与两亲性物质在疏水性离子络合物中的药物。 还提供了一种用于制造组合物的压缩抗溶剂方法，包含组合物的各种产品形式和用于组合物的各种用途。
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公开(公告)号：US06482435B1
公开(公告)日：2002-11-19
申请号：US09232288
申请日：1999-01-15
Applicant: Lewis P. Stratton , John F. Carpenter , Mark C. Manning
Inventor： Lewis P. Stratton , John F. Carpenter , Mark C. Manning
IPC: A61K910
CPC classification number: A61K9/0024 , A61K9/0019 , A61K38/28 , A61K38/443 , A61K38/482 , A61K38/4826 , A61K47/10 , Y10S514/944
Abstract: Pharmaceutical compositions for the delivery of pharmacologically active proteins are provided by the present invention. The compositions of the present invention comprise a polymeric matrix having thermal gelation properties in which is incorporated a discrete suspension of at least one biologically active macromolecular polypeptide which retains greater than 90 percent of its biological activity. Furthermore, the concentration of the macromolecular polypeptide is greater than 0.5 percent by weight of the composition.
Abstract translation: 用于递送药理活性蛋白质的药物组合物由本发明提供。 本发明的组合物包含具有热凝胶化特性的聚合物基质，其中加入保留其生物活性的90％以上的至少一种生物活性大分子多肽的分散悬浮液。 此外，大分子多肽的浓度大于组合物重量的0.5％。
