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公开(公告)号：US20050002931A1
公开(公告)日：2005-01-06
申请号：US10823506
申请日：2004-04-12
申请人： Carl Hellerqvist , Changlin Fu
发明人： Carl Hellerqvist , Changlin Fu
IPC分类号： A61K38/00 , C07K14/705 , A61K39/395 , C07K16/28
CPC分类号： C07K14/705 , A61K38/00
摘要： A novel GBS toxin receptor, and methods for its preparation and use are provided. GBS toxin receptor polynucleotides and polypeptides are provided as well as detection, screening, and therapeutic methods and pharmaceutical compositions involving such polynucleotides and polypeptides.
摘要翻译： 提供了一种新型的GBS毒素受体及其制备和使用方法。 提供GBS毒素受体多核苷酸和多肽以及涉及这种多核苷酸和多肽的检测，筛选和治疗方法以及药物组合物。
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公开(公告)号：US20070234442A1
公开(公告)日：2007-10-04
申请号：US11695108
申请日：2007-04-02
申请人： Changlin Fu , Brian Hauge , Vicky Gavrias
发明人： Changlin Fu , Brian Hauge , Vicky Gavrias
CPC分类号： C12N15/8273 , C07K14/415 , C12N9/1205
摘要： Synthetic modular polynucleotide constructs are useful for gene expression in plants, methods for making and using such constructs, and plants transformed with such constructs. The constructs comprise unique restriction sites for each modular element and may further comprise polynucleotide identifier sequences.
摘要翻译： 合成的模块化多核苷酸构建体可用于植物中的基因表达，用于制备和使用这些构建体的方法，以及用这些构建体转化的植物。 构建体包含用于每个模块化元件的独特的限制性位点，并且还可以包含多核苷酸标识符序列。
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公开(公告)号：US20110217316A1
公开(公告)日：2011-09-08
申请号：US13022357
申请日：2011-02-07
申请人： Carl G. Hellerqvist , Changlin Fu
发明人： Carl G. Hellerqvist , Changlin Fu
IPC分类号： A61K39/395 , C07K14/00 , C07H21/04 , C07K16/00 , A61K39/00 , A61K31/7088 , A61P35/00 , A61P37/04 , G01N33/566 , C12Q1/02 , G01N33/567
CPC分类号： A61K31/7088 , A61K39/00 , A61K39/395 , C07H21/04 , C07K14/00 , C07K16/00 , C12Q1/02 , G01N33/566 , G01N33/567
摘要： Methods are provided for preventing or attenuating pathoangiogenic conditions by administering at least one GBS toxin receptor polypeptide or at least one immunogenic fragment thereof. Also provided are a composition that includes a GBS toxin receptor polypeptide and a method for making such a composition. In another embodiment of the invention, immunized animals also receive GBS toxin, immunocompatible antibodies to the GBS toxin receptor, and/or expanded autologous T cells to the GBS toxin receptor. Also included in this invention are methods of identifying additional GBS toxin receptors.
摘要翻译： 提供了通过施用至少一种GBS毒素受体多肽或其至少一种免疫原性片段来预防或减弱病原体病症的方法。 还提供了包含GBS毒素受体多肽的组合物和制备这种组合物的方法。 在本发明的另一个实施方案中，免疫动物还接受GBS毒素，与GBS毒素受体的免疫相容抗体和/或扩增的自体T细胞至GBS毒素受体。 本发明还包括鉴定另外的GBS毒素受体的方法。
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公开(公告)号：US08609614B2
公开(公告)日：2013-12-17
申请号：US13022357
申请日：2011-02-07
申请人： Carl G. Hellerqvist , Changlin Fu
发明人： Carl G. Hellerqvist , Changlin Fu
IPC分类号： A61K38/17 , A61K38/03 , C07K14/435
CPC分类号： A61K31/7088 , A61K39/00 , A61K39/395 , C07H21/04 , C07K14/00 , C07K16/00 , C12Q1/02 , G01N33/566 , G01N33/567
摘要： Methods are provided for preventing or attenuating pathoangiogenic conditions by administering at least one GBS toxin receptor polypeptide or at least one immunogenic fragment thereof. Also provided are a composition that includes a GBS toxin receptor polypeptide and a method for making such a composition. In another embodiment of the invention, immunized animals also receive GBS toxin, immunocompatible antibodies to the GBS toxin receptor, and/or expanded autologous T cells to the GBS toxin receptor. Also included in this invention are methods of identifying additional GBS toxin receptors.
摘要翻译： 提供了通过施用至少一种GBS毒素受体多肽或其至少一种免疫原性片段来预防或减弱病原体病症的方法。 还提供了包含GBS毒素受体多肽的组合物和制备这种组合物的方法。 在本发明的另一个实施方案中，免疫动物还接受GBS毒素，与GBS毒素受体的免疫相容抗体和/或扩增的自体T细胞至GBS毒素受体。 本发明还包括鉴定另外的GBS毒素受体的方法。
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公开(公告)号：US07888557B2
公开(公告)日：2011-02-15
申请号：US10783710
申请日：2004-02-21
申请人： Jindong Sun , Kimberly Zobrist , Jingrui Wu , Changlin Fu , Stanton B. Dotson , Linda Lutfiyya
发明人： Jindong Sun , Kimberly Zobrist , Jingrui Wu , Changlin Fu , Stanton B. Dotson , Linda Lutfiyya
IPC分类号： C12N15/82
CPC分类号： C07K14/415 , C07K14/4702 , C12N15/8247 , C12N15/8261 , C12N15/8273 , Y02A40/146
摘要： Disclosed herein are transgenic plants having recombinant DNA which expresses a G1073 transcription factor which provides enhanced resistance and/or tolerance to water deficit. More specifically the DNA constructs comprise a polynucleotide which encodes at least a functional part of a G1073 transcription factor or a homologous transcription factor.
摘要翻译： 本文公开了具有表达G1073转录因子的重组DNA的转基因植物，其提供增强的抗性和/或耐水亏性。 更具体地，DNA构建体包含编码G1073转录因子或同源转录因子的至少功能部分的多核苷酸。
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公开(公告)号：US07410640B2
公开(公告)日：2008-08-12
申请号：US10823506
申请日：2004-04-12
申请人： Carl G. Hellerqvist , Changlin Fu
发明人： Carl G. Hellerqvist , Changlin Fu
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K14/705 , A61K38/00
摘要： A novel GBS toxin receptor and methods for its preparation and use are provided. GBS toxin receptor polynucleotides and polypeptides and antibodies to GBS toxin receptor are provided, as well as detection, screening, and therapeutic methods and pharmaceutical compositions involving such polynucleotides, polypeptides and antibodies.
摘要翻译： 提供了一种新型的GBS毒素受体及其制备和使用方法。 提供GBS毒素受体多核苷酸和GBS毒素受体的多肽和抗体，以及检测，筛选和治疗方法以及涉及这种多核苷酸，多肽和抗体的药物组合物。
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公开(公告)号：US07754944B2
公开(公告)日：2010-07-13
申请号：US11695108
申请日：2007-04-02
申请人： Changlin Fu , Brian Hauge , Vicky Gavrias
发明人： Changlin Fu , Brian Hauge , Vicky Gavrias
CPC分类号： C12N15/8273 , C07K14/415 , C12N9/1205
摘要： Synthetic modular polynucleotide constructs are useful for gene expression in plants, methods for making and using such constructs, and plants transformed with such constructs. The constructs comprise unique restriction sites for each modular element and may further comprise polynucleotide identifier sequences.
摘要翻译： 合成的模块化多核苷酸构建体可用于植物中的基因表达，用于制备和使用这些构建体的方法，以及用这些构建体转化的植物。 构建体包含用于每个模块化元件的独特的限制性位点，并且还可以包含多核苷酸标识符序列。
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公开(公告)号：US20100076184A1
公开(公告)日：2010-03-25
申请号：US12142060
申请日：2008-06-19
申请人： Carl G. Hellerqvist , Changlin Fu
发明人： Carl G. Hellerqvist , Changlin Fu
IPC分类号： C07H21/04
CPC分类号： C07K14/705 , A61K38/00
摘要： A novel GBS toxin receptor, and methods for its preparation and use are provided. GBS toxin receptor polynucleotides and polypeptides are provided as well as detection, screening, and therapeutic methods and pharmaceutical compositions involving such polynucleotides and polypeptides.
摘要翻译： 提供了一种新型的GBS毒素受体及其制备和使用方法。 提供GBS毒素受体多核苷酸和多肽以及涉及这种多核苷酸和多肽的检测，筛选和治疗方法以及药物组合物。
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公开(公告)号：US20090221804A1
公开(公告)日：2009-09-03
申请号：US12331067
申请日：2008-12-09
申请人： Carl G. Hellerqvist , Changlin Fu
发明人： Carl G. Hellerqvist , Changlin Fu
IPC分类号： C07K16/28
CPC分类号： A61K39/0011
摘要： Methods are provided for preventing or attenuating pathoangiogenic conditions by administering at least one GBS toxin receptor polypeptide or at least one immunogenic fragment thereof. Also provided are a composition that includes a GBS toxin receptor polypeptide and a method for making such a composition. In another embodiment of the invention, immunized animals also receive GBS toxin, immunocompatible antibodies to the GBS toxin receptor, and/or expanded autologous T cells to the GBS toxin receptor. Also included in this invention are methods of identifying additional GBS toxin receptors.
摘要翻译： 提供了通过施用至少一种GBS毒素受体多肽或其至少一种免疫原性片段来预防或减弱病原体病症的方法。 还提供了包含GBS毒素受体多肽的组合物和制备这种组合物的方法。 在本发明的另一个实施方案中，免疫动物还接受GBS毒素，与GBS毒素受体的免疫相容抗体和/或扩增的自体T细胞至GBS毒素受体。 本发明还包括鉴定另外的GBS毒素受体的方法。
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公开(公告)号：US20050097631A1
公开(公告)日：2005-05-05
申请号：US10783710
申请日：2004-02-21
申请人： Jindong Sun , Kimberly Zobrist , Jingrui Wu , Changlin Fu , Stanton Dotson , Linda Lutfiyya
发明人： Jindong Sun , Kimberly Zobrist , Jingrui Wu , Changlin Fu , Stanton Dotson , Linda Lutfiyya
CPC分类号： C07K14/415 , C07K14/4702 , C12N15/8247 , C12N15/8261 , C12N15/8273 , Y02A40/146
摘要： Disclosed herein are transgenic plants having recombinant DNA which expresses a G1073 transcription factor which provides enhanced resistance and/or tolerance to water deficit. More specifically the DNA constructs comprise a polynucleotide which encodes a at least a functional part of a G1073 transcription factor or a homologous transcription factor.
摘要翻译： 本文公开了具有表达G1073转录因子的重组DNA的转基因植物，其提供增强的抗性和/或耐水亏性。 更具体地，DNA构建体包含编码G1073转录因子或同源转录因子的至少功能部分的多核苷酸。
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