利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.038 秒)

    DEVICE AND A METHOD FOR PROMOTING CRYSTALLISATION
    7.
    发明申请
    DEVICE AND A METHOD FOR PROMOTING CRYSTALLISATION 有权
    装置和促进结晶的方法

    公开(公告)号：US20090264632A1

    公开(公告)日：2009-10-22

    申请号：US12303132

    申请日：2007-06-27

    申请人： Morten Sommer

    发明人： Morten Sommer

    IPC分类号： C07K1/30 ,  B01D9/00 ,  C07H1/06 ,  C07H21/00

    CPC分类号： C30B29/58 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2300/041 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0688 ,  B01L2400/0694 ,  C30B7/00 ,  C30B35/00 ,  Y10T117/10

    摘要： The invention relates to a microfluidic device for promoting crystallisation of target molecules, such as proteins. The device comprises a solid structure with a top face and an opposite bottom face and with a least one liquid channel. The liquid channel comprises a target molecule solution inlet and at least two precipitant inlets. The target molecule solution inlet is in liquid communication with each of the precipitant inlets through the liquid channel. The liquid channel comprises a branching channel section adjacent to the target molecule solution inlet, crystallisation channel sections adjacent to the respective precipitant inlets and flow break channel sections arranged between the branching channel section and each of the crystallization channel sections. The liquid channel is branched from 1 to X in the branching channel section, wherein X is the number of crystallisation channel sections, and the flow break channel sections comprise a flow break arrangement capable of breaking up the liquid communication between said respective branching channel section and crystallisation channel sections.

    摘要翻译： 本发明涉及用于促进目标分子如蛋白质结晶的微流体装置。 该装置包括具有顶面和相对底面以及至少一个液体通道的固体结构。 液体通道包括靶分子溶液入口和至少两个沉淀剂入口。 目标分子溶液入口通过液体通道与每个沉淀剂入口液体连通。 液体通道包括与目标分子溶液入口相邻的分支通道部分，与相应的沉淀剂入口相邻的结晶通道部分和布置在分支通道部分和每个结晶通道部分之间的流动断裂通道部分。 液体通道在分支通道部分中从1分支到X，其中X是结晶通道部分的数量，并且流动断裂通道部分包括能够分解所述相应分支通道部分和 结晶通道部分。

    Crystallization media
    8.
    发明授权
    Crystallization media 有权
    结晶介质

    公开(公告)号：US08652417B2

    公开(公告)日：2014-02-18

    申请号：US13010298

    申请日：2011-01-20

    申请人： Morten Sommer

    发明人： Morten Sommer

    IPC分类号： G01N33/00

    CPC分类号： C30B29/58 ,  C30B7/00

    摘要： A set of crystallization solutions includes a plurality of crystallization solutions of Crystallization Solution Set I, a plurality of crystallization solutions of Crystallization Solution Set II or a plurality of crystallization solutions of Crystallization Solution Set III.

    摘要翻译： 一组结晶溶液包括结晶溶液组I的多个结晶溶液，结晶溶液组II的多个结晶溶液或结晶溶液组III的多个结晶溶液。

    Device and a method for promoting crystallisation
    9.
    发明授权
    Device and a method for promoting crystallisation 有权
    装置和促进结晶的方法

    公开(公告)号：US08986449B2

    公开(公告)日：2015-03-24

    申请号：US12303132

    申请日：2007-06-27

    申请人： Morten Sommer

    发明人： Morten Sommer

    IPC分类号： C30B35/00 ,  C30B29/58 ,  B01L3/00 ,  C30B7/00

    CPC分类号： C30B29/58 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2300/041 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0688 ,  B01L2400/0694 ,  C30B7/00 ,  C30B35/00 ,  Y10T117/10

    摘要： The invention relates to a microfluidic device for promoting crystallization of target molecules, such as proteins. The device comprises a solid structure with a top face and an opposite bottom face and with a least one liquid channel. The liquid channel comprises a target molecule solution inlet and at least two precipitant inlets. The target molecule solution inlet is in liquid communication with each of the precipitant inlets through the liquid channel. The liquid channel comprises a branching channel section adjacent to the target molecule solution inlet, crystallization channel sections adjacent to the respective precipitant inlets and flow break channel sections arranged between the branching channel section and each of the crystallization channel sections. The liquid channel is branched from 1 to X in the branching channel section, wherein X is the number of crystallization channel sections, and the flow break channel sections comprise a flow break arrangement capable of breaking up the liquid communication between said respective branching channel section and crystallization channel sections.

    摘要翻译： 本发明涉及用于促进目标分子如蛋白质结晶的微流体装置。 该装置包括具有顶面和相对底面以及至少一个液体通道的固体结构。 液体通道包括靶分子溶液入口和至少两个沉淀剂入口。 目标分子溶液入口通过液体通道与每个沉淀剂入口液体连通。 液体通道包括与目标分子溶液入口相邻的分支通道部分，与相应的沉淀剂入口相邻的结晶通道部分和布置在分支通道部分和每个结晶通道部分之间的流动断裂通道部分。 液体通道在分支通道部分中从1分支到X，其中X是结晶通道部分的数量，并且流动断裂通道部分包括能够破坏所述相应分支通道部分和 结晶通道部分。

    CRYSTALLIZATION SYSTEM AND METHOD FOR PROMOTING CRYSTALLIZATION
    10.
    发明申请
    CRYSTALLIZATION SYSTEM AND METHOD FOR PROMOTING CRYSTALLIZATION 审中-公开
    用于促进结晶的结晶系统和方法

    公开(公告)号：US20120020850A1

    公开(公告)日：2012-01-26

    申请号：US13202952

    申请日：2010-02-23

    申请人： Morten Sommer

    发明人： Morten Sommer

    IPC分类号： G01N33/50 ,  B23P11/00 ,  B01D9/00

    CPC分类号： B01L3/50853 ,  B01L2300/0829 ,  B01L2300/0887 ,  C30B7/00 ,  C30B35/00 ,  Y10T29/49826

    摘要： A crystallization system includes a well plate and a cover for the well plate, at least one of the well plate and said cover includes at least a transparent window. The well plate including at least one well comprising a bottom surface including a first essentially planar bottom surface section and a second essentially planar bottom surface section in a first bottom plane and a well border wall provided by a well border edge surrounding the planar bottom surface section: The cover includes a first essentially planar top surface section in a first top plane adapted to face the first essentially planar bottom surface section. The first and the second essentially planar bottom surface sections are totally or partly separated by a liquid barrier, provided by one or more of a low tension surface barrier, a ridge and an indentation. A method of producing the crystallization system includes providing a bottom plate, a perforated plate and a cover, mounting the bottom plate to the perforated plate to provide a well plate including a plurality of wells each having a bottom surface. The system is simple and cost effective to produce and simple to handle.

    摘要翻译： 结晶系统包括井板和用于井板的盖，井板和所述盖中的至少一个至少包括透明窗。 所述井板包括至少一个井，所述井包括底表面，所述井底表面包括第一基本平坦的底表面区段和在第一底部平面中的第二基本上平面的底表面部分以及由围绕所述平坦底表面部分的井口边缘边缘提供的井口边界壁 盖子包括适于面对第一基本平坦的底表面部分的第一顶部平面中的第一基本平坦的顶部表面部分。 第一和第二基本上平面的底表面部分由液体屏障全部或部分地分开，该液体屏障由低压表面屏障，脊和凹陷中的一个或多个提供。 一种生产结晶系统的方法包括提供底板，多孔板和盖，将底板安装到多孔板上，以提供一个井板，该井板包括多个具有底面的孔。 该系统生产简单，成本低廉，操作简单。