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85 条记录 (耗时 0.047 秒)

    Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract
    1.
    发明授权
    Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract 失效
    用于可视化胃肠道的成膜材料中碘苯氧基烷烃和碘苯基醚的组成

    公开(公告)号：US5326553A

    公开(公告)日：1994-07-05

    申请号：US12171

    申请日：1993-02-02

    申请人： Carl R. Illig ,  Eugene R. Cooper ,  John L. Toner ,  Donald A. Upson ,  Brent D. Douty ,  Thomas J. Caulfield ,  Bacon, Edward R. ,  Kimberly G. Estep ,  Kurt A. Josef ,  Shaughnessy Robinson ,  Paul P. Spara

    发明人： Carl R. Illig ,  Eugene R. Cooper ,  John L. Toner ,  Donald A. Upson ,  Brent D. Douty ,  Thomas J. Caulfield ,  Bacon, Edward R. ,  Kimberly G. Estep ,  Kurt A. Josef ,  Shaughnessy Robinson ,  Paul P. Spara

    IPC分类号： A61K49/04 ,  A61K31/075

    CPC分类号： A61K49/0433 ,  Y10S514/941 ,  Y10S514/942

    摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract whereinZ=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxycarbonyloxy, (CR.sub.1 R.sub.2).sub.p-- (CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-5;m is 1-15;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkylin a pharmaceutically acceptable carrier.

    摘要翻译： 公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含能够在胃肠道上形成涂层的聚合物材料和具有式“IMAGE”的X射线产生剂及其用于诊断放射学的方法 的胃肠道，其中Z = H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代; 任选被卤素，氟 - 低级 - 烷基，芳基，低级 - 烷氧基，羟基，羧基，低级 - 烷氧基羰基或低级 - 烷氧基羰基氧基取代的C 1 -C 25烷基，环烷基或卤代低级烷基，（CR 1 R 2）p - （CR3 = CR4）mQ，或（CR1R2）pC 3BOND CQ; R 1，R 2，R 3和R 4独立地为低级烷基，任选被卤素取代; x为1-4; n为1-5; m为1-15; p为1-10; Q为药学上可接受的载体中的H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基。

    Compositions of iodophenoxy alkylene ethers and cellulose derivatives for visualization of the gastrointestinal tract
    6.
    发明授权
    Compositions of iodophenoxy alkylene ethers and cellulose derivatives for visualization of the gastrointestinal tract 失效
    碘苯氧基亚烷基醚和纤维素衍生物用于胃肠道可视化的组合物

    公开(公告)号：US5466435A

    公开(公告)日：1995-11-14

    申请号：US222787

    申请日：1994-04-04

    申请人： Edward J. Baker ,  Edward R Bacon ,  Carl R. Illig ,  Thomas J. Caulfield ,  Brent D. Douty ,  Kurt A. Josef ,  John L. Toner ,  Robert W. Lee

    发明人： Edward J. Baker ,  Edward R Bacon ,  Carl R. Illig ,  Thomas J. Caulfield ,  Brent D. Douty ,  Kurt A. Josef ,  John L. Toner ,  Robert W. Lee

    IPC分类号： A61K49/04 ,  C07C43/225 ,  C07C43/23 ,  C07C69/92 ,  C07C255/54

    CPC分类号： A61K49/0404 ,  A61K49/04 ,  A61K49/0409 ,  A61K49/0461 ,  C07C43/225

    摘要： Disclosed are contrast agents of the formula ##STR1## wherein Z is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R is C.sub.1 -C.sub.25 alkyl, cycloalkyl, ##STR2## or halo-lower-alkyl; each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy;(CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H or lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-4;m is 1-15;p is 1-20; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl;in an aqueous, pharmaceutically acceptable carrier comprising a cellulose derivative.

    摘要翻译： 公开了式IMA的造影剂，其中Z是H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，烷氧基羰基，氰基，其中烷基和环烷基可以被卤素或卤代低级烷基取代; R为C1-C25烷基，环烷基，低级或低级烷基; 其中每一个可以任选被卤素，氟 - 低级 - 烷基，芳基，低级 - 烷氧基，羟基，羧基，低级 - 烷氧基羰基或低级 - 烷氧基 - 羰氧基取代; （CR 1 R 2）p - （CR 3 = CR 4）m Q或（CR 1 R 2）p -C 3OND C-Q; R 1，R 2，R 3和R 4独立地为H或低级烷基，任选被卤素取代; x为1-4; n为1-4; m为1-15; p是1-20; Q为H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基; 在包含纤维素衍生物的水性药学上可接受的载体中。

    Compositions of iodophenyl esters and iodophenyl sulfonates in film-forming materials for visualization of the gastrointestinal tract
    9.
    发明授权
    Compositions of iodophenyl esters and iodophenyl sulfonates in film-forming materials for visualization of the gastrointestinal tract 失效
    碘苯基酯和碘苯基磺酸盐在成膜材料中用于胃肠道可视化的组合物

    公开(公告)号：US5372800A

    公开(公告)日：1994-12-13

    申请号：US192234

    申请日：1994-02-04

    申请人： Edward R. Bacon ,  Sol J. Daum ,  Kimberly G. Estep ,  Kurt A. Josef ,  Brent D. Douty ,  Carl R. Illig

    发明人： Edward R. Bacon ,  Sol J. Daum ,  Kimberly G. Estep ,  Kurt A. Josef ,  Brent D. Douty ,  Carl R. Illig

    IPC分类号： A61K9/107 ,  A61K47/02 ,  A61K47/36 ,  A61K47/38 ,  A61K49/04 ,  C07C69/63

    CPC分类号： A61K49/0433 ,  Y10S514/941 ,  Y10S514/942

    摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract whereinX= ##STR2## Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, aryl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy,n is 1-5;y is 0-4; andw is 1-4.

    摘要翻译： 公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含能够在胃肠道上形成涂层的聚合物材料和具有式“IMAGE”的X射线产生剂及其用于诊断放射学的方法 的胃肠道，其中X = Z，H =卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代; R = C 1 -C 25烷基，环烷基，芳基或卤代低级烷基，任选被卤素，氟代低级烷基，低级烷氧基，羟基，羧基或低级烷氧基羰基，低级烯基，低级炔基，低级 - 亚烷基或低级 - 烷氧基 - 羰氧基，n为1-5; y为0-4; w为1-4。

    Compositions of alkylbenzenes in film-forming materials for visualization of the gastrointestinal tract
    10.
    发明授权
    Compositions of alkylbenzenes in film-forming materials for visualization of the gastrointestinal tract 失效
    用于胃肠道可视化的成膜材料中烷基苯的组成

    公开(公告)号：US5334370A

    公开(公告)日：1994-08-02

    申请号：US13459

    申请日：1993-02-04

    申请人： Kurt A. Josef ,  Edward R. Bacon ,  Kimberly G. Estep ,  Carl R. Illig ,  Brent D. Douty

    发明人： Kurt A. Josef ,  Edward R. Bacon ,  Kimberly G. Estep ,  Carl R. Illig ,  Brent D. Douty

    IPC分类号： A61K49/04 ,  C07C17/12 ,  C07C17/26 ,  C07C17/354 ,  C07C25/02 ,  C07C69/65 ,  C07C22/00 ,  C07C25/00 ,  C07C69/76

    CPC分类号： C07C17/12 ,  A61K49/0461 ,  C07C17/2635 ,  C07C17/354 ,  C07C25/02 ,  C07C69/65

    摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract whereinR=C.sub.1 -C.sub.25 alkyl, cycloalkyl, unsaturated allyl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H, lower-alkyl, optionally substituted with halo;n is 1-5;m is 1-5;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.

    摘要翻译： 公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含能够在胃肠道上形成涂层的聚合物材料和具有式“IMAGE”的X射线产生剂及其用于诊断放射学的方法 的胃肠道，其中R = C 1 -C 25烷基，环烷基，不饱和烯丙基或卤代低级烷基，任选被卤素，氟 - 低级 - 烷基，芳基，低级 - 烷氧基，羟基，羧基，低级 - 烷氧基羰基或低级 （CR 1 R 2）p - （CR 3 = CR 4）m Q或（CR 1 R 2）p C 3 B 3 CQ; R 1，R 2，R 3和R 4独立地为H，低级烷基，任选被卤素取代; n为1-5; m为1-5; p为1-10; 并且Q是H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基。