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    Compositions of iodoaniline derivatives and cellulose derivatives for visualization of the gastrointestinal tract
    1.
    发明授权
    Compositions of iodoaniline derivatives and cellulose derivatives for visualization of the gastrointestinal tract 失效
    用于可视化胃肠道的碘苯胺衍生物和纤维素衍生物的组合物

    公开(公告)号：US5422114A

    公开(公告)日：1995-06-06

    申请号：US201731

    申请日：1994-02-25

    申请人： Carl R. Illig ,  Thomas J. Caulfield ,  Robert W. Lee ,  Edward J. Baker

    发明人： Carl R. Illig ,  Thomas J. Caulfield ,  Robert W. Lee ,  Edward J. Baker

    IPC分类号： A61K9/107 ,  A61K49/04 ,  C08K5/315 ,  C08L101/00 ,  C08L101/06 ,  G01N21/00

    CPC分类号： A61K49/0404 ,  A61K49/0409 ,  A61K49/0461

    摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract, whereinZ is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R.sub.1 and R.sub.2 are independently H, C.sub.1 -C.sub.25 alkyl, cycloalkyl, acetyl or halo-lower-alkyl, wherein said C.sub.1 -C.sub.25 alkyl, cycloalkyl and halo lower-alkyl are optionally substituted with fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy and said acetyl is optionally substituted with fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy;n is 1-4;y is 1-4; andx is 1 or 2in a pharmaceutically acceptable carrier comprising a cellulose derivative.

    摘要翻译： 公开了用于胃肠道口服或逆行检查的x射线造影剂组合物，其包含下式的x射线产生剂或其药学上可接受的盐及其用于胃肠道诊断放射学的方法，其中Z 是H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代; R 1和R 2独立地为H，C 1 -C 25烷基，环烷基，乙酰基或卤代低级烷基，其中所述C 1 -C 25烷基，环烷基和卤代低级烷基任选被氟 - 低级 - 烷基，芳基，低级 - 烷氧基 ，羟基，羧基，低级烷氧基羰基或低级烷氧基 - 羰氧基，所述乙酰基任选被氟 - 低级 - 烷基，芳基，低级 - 烷氧基，羟基，低级 - 烷氧基羰基或低级 - 烷氧基 - 羰氧基取代; n为1-4; y为1-4; 并且在包含纤维素衍生物的药学上可接受的载体中x为1或2。

    Compositions of iodophenoxy alkylene ethers and cellulose derivatives for visualization of the gastrointestinal tract
    2.
    发明授权
    Compositions of iodophenoxy alkylene ethers and cellulose derivatives for visualization of the gastrointestinal tract 失效
    碘苯氧基亚烷基醚和纤维素衍生物用于胃肠道可视化的组合物

    公开(公告)号：US5466435A

    公开(公告)日：1995-11-14

    申请号：US222787

    申请日：1994-04-04

    申请人： Edward J. Baker ,  Edward R Bacon ,  Carl R. Illig ,  Thomas J. Caulfield ,  Brent D. Douty ,  Kurt A. Josef ,  John L. Toner ,  Robert W. Lee

    发明人： Edward J. Baker ,  Edward R Bacon ,  Carl R. Illig ,  Thomas J. Caulfield ,  Brent D. Douty ,  Kurt A. Josef ,  John L. Toner ,  Robert W. Lee

    IPC分类号： A61K49/04 ,  C07C43/225 ,  C07C43/23 ,  C07C69/92 ,  C07C255/54

    CPC分类号： A61K49/0404 ,  A61K49/04 ,  A61K49/0409 ,  A61K49/0461 ,  C07C43/225

    摘要： Disclosed are contrast agents of the formula ##STR1## wherein Z is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R is C.sub.1 -C.sub.25 alkyl, cycloalkyl, ##STR2## or halo-lower-alkyl; each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy;(CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H or lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-4;m is 1-15;p is 1-20; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl;in an aqueous, pharmaceutically acceptable carrier comprising a cellulose derivative.

    摘要翻译： 公开了式IMA的造影剂，其中Z是H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，烷氧基羰基，氰基，其中烷基和环烷基可以被卤素或卤代低级烷基取代; R为C1-C25烷基，环烷基，低级或低级烷基; 其中每一个可以任选被卤素，氟 - 低级 - 烷基，芳基，低级 - 烷氧基，羟基，羧基，低级 - 烷氧基羰基或低级 - 烷氧基 - 羰氧基取代; （CR 1 R 2）p - （CR 3 = CR 4）m Q或（CR 1 R 2）p -C 3OND C-Q; R 1，R 2，R 3和R 4独立地为H或低级烷基，任选被卤素取代; x为1-4; n为1-4; m为1-15; p是1-20; Q为H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基; 在包含纤维素衍生物的水性药学上可接受的载体中。

    Polymeric x-ray contrast compositions containing iodinated polymeric beads and microcrystaline cellulose
    7.
    发明授权
    Polymeric x-ray contrast compositions containing iodinated polymeric beads and microcrystaline cellulose 失效
    含有碘化聚合物珠粒和微晶纤维素的聚合X射线对比组合物

    公开(公告)号：US5525327A

    公开(公告)日：1996-06-11

    申请号：US227415

    申请日：1994-04-14

    申请人： Edward J. Baker ,  Robert W. Lee ,  Carl R. Illig ,  John L. Toner

    发明人： Edward J. Baker ,  Robert W. Lee ,  Carl R. Illig ,  John L. Toner

    IPC分类号： A61K49/04

    CPC分类号： A61K49/0409 ,  A61K49/04 ,  A61K49/0404 ,  A61K49/0433 ,  Y10S514/941 ,  Y10S514/942

    摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodinated polymeric, water-insoluble beads having a particle size of from about 0.01 to about 1000.mu. wherein said iodinated polymeric beads comprise a polymer containing repeating units of the formula (I) ##STR1## wherein A is a repeating organic unit in the backbone chain of the polymer; and X is an organic moiety containing or iodinated eromatic group and a hydrophilic group, said moiety having an iodine content within the range of from about 40 to about 80 weight percent based or the molecular weight of X, in a pharmaceutically acceptable carrier comprising a cellulose derivative.

    摘要翻译： 公开了用于口腔或逆行检查胃肠道的X射线造影剂组合物，其包含粒径为约0.01至约1000μm的碘化聚合物，水不溶性珠粒，其中所述碘化聚合物珠粒包含含有式 （I）其中A是聚合物的主链中的重复有机单元; 并且X是含有或碘化的丙烯酸基团和亲水基团的有机部分，所述部分在药学上可接受的载体中具有在约40至约80重量％的范围内或基于X的分子量的碘含量，其包含纤维素 衍生物。

    Compositions of iodobenzoic acid derivatives and cellulose derivatives for visualization of the gastrointestinal tract
    9.
    发明授权
    Compositions of iodobenzoic acid derivatives and cellulose derivatives for visualization of the gastrointestinal tract 失效
    碘苯甲酸衍生物和纤维素衍生物用于胃肠道可视化的组合物

    公开(公告)号：US5385720A

    公开(公告)日：1995-01-31

    申请号：US216988

    申请日：1994-03-23

    申请人： Edward J. Baker ,  Robert W. Lee ,  Carl R. Illig ,  Brent D. Douty ,  John L. Toner

    发明人： Edward J. Baker ,  Robert W. Lee ,  Carl R. Illig ,  Brent D. Douty ,  John L. Toner

    IPC分类号： A61K47/30 ,  A61K49/04 ,  C08K5/07 ,  A61K31/235 ,  A61K31/715

    CPC分类号： A61K49/0404 ,  A61K49/04 ,  A61K49/0409 ,  A61K49/0433 ,  Y10S514/941 ,  Y10S514/942

    摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof ##STR1## wherein Z is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R is C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy;(CR.sub.1 R.sub.2).sub.p -- (CR.sub.3 =CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p -- C.dbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo;x is 1--3y is 1--4;n is 1--5;m is 1--15;p is 1--10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl in a pharmaceutically acceptable carrier comprising a cellulose derivative.

    摘要翻译： 公开了用于胃肠道口服或逆行检查的x射线造影剂组合物，其包含下式的x射线产生剂或其药学上可接受的盐，其中Z为H，卤素，C 1 -C 20烷基，环烷基，低级 烷氧基，氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代; R是C 1 -C 25烷基，环烷基或卤代低级烷基，其各自可以任选被卤素，氟代低级烷基，芳基，低级烷氧基，羟基，羧基，低级烷氧基羰基或低级烷氧基 羰基氧基; （CR 1 R 2）p - （CR 3 = CR 4）m Q或（CR 1 R 2）p -C = C-Q; R 1，R 2，R 3和R 4独立地为低级烷基，任选被卤素取代; x为1-3 y为1-4; n为1-5; m为1-15; p为1-10; Q为包含纤维素衍生物的药学上可接受的载体中的H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基。