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公开(公告)号:US09505775B2
公开(公告)日:2016-11-29
申请号:US14440085
申请日:2013-10-31
申请人: Carl Thibeault , Jean Rancourt , Pierre L. Beaulieu , Anne Décor , Chantal Grand-Maitre , Cyrille Kuhn , Elisia Villemure , Oliver Hucke , Simon Surprenant , Melissa Leblanc , Jean-Eric Lacoste , Benoit Moreau , Eric Jolicoeur
发明人: Carl Thibeault , Jean Rancourt , Pierre L. Beaulieu , Anne Décor , Chantal Grand-Maitre , Cyrille Kuhn , Elisia Villemure , Oliver Hucke , Simon Surprenant , Melissa Leblanc , Jean-Eric Lacoste , Benoit Moreau , Eric Jolicoeur
IPC分类号: C07D403/14 , C07D403/06 , C07D413/14 , C07D401/14 , C07D209/04 , A61K31/404 , A61K31/4178 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/44 , A61K31/497 , C07D491/107 , C07D403/08 , C07D471/04 , C07D487/10 , C07D471/10
CPC分类号: C07D491/107 , C07D401/14 , C07D403/06 , C07D403/08 , C07D403/14 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/10
摘要: Compounds of Formula (I) wherein R1, R2, R3A, R3B, Y, Z1 and Z2 are defined herein, are useful for the treatment of cytomegalovirus disease and/or infection.
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公开(公告)号:US20150274744A1
公开(公告)日:2015-10-01
申请号:US14440085
申请日:2013-10-31
申请人: Carl THIBEAULT , Jean RANCOURT , Pierre L. BEAULIEU , Anne DECOR , Chantal GRAND-MAITRE , Cyille KUHN , Elisia VILLEMURE , Melissa LEBLANC , Jene-Eric LACOSTE , Benoit MOREAU , Eric JOLICOEUR , Simon SURPRENANT , Oliver HUCKE
发明人: Carl Thibeault , Jean Rancourt , Pierre L. Beaulieu , Anne Décor , Chantal Grand-Maitre , Cyrille Kuhn , Elisia Villemure , Oliver Hucke , Simon Surprenant , Melissa Leblanc , Jean-Eric Lacoste , Benoit Moreau , Eric Jolicoeur
IPC分类号: C07D491/107 , C07D401/14 , C07D471/10 , C07D413/14 , C07D403/14 , C07D403/06
CPC分类号: C07D491/107 , C07D401/14 , C07D403/06 , C07D403/08 , C07D403/14 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/10
摘要: Compounds of Formula (I) wherein R1, R2, R3A, R3B, Y, Z1 and Z2 are defined herein, are useful for the treatment of cytomegalovirus disease and/or infection.
摘要翻译: 其中R1,R2,R3A,R3B,Y,Z1和Z2在本文中定义的式(I)化合物可用于治疗巨细胞病毒疾病和/或感染。
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公开(公告)号:US08722695B2
公开(公告)日:2014-05-13
申请号:US13515097
申请日:2010-12-06
申请人: Giuseppe Alvaro , Anne Décor , Stefano Fontana , Dieter Hamprecht , Charles Large , Agostino Marasco
发明人: Giuseppe Alvaro , Anne Décor , Stefano Fontana , Dieter Hamprecht , Charles Large , Agostino Marasco
IPC分类号: A01N43/54 , A61K31/505 , C07D239/22 , C07D239/47 , C07D213/643
CPC分类号: A61K31/506 , A61K31/4166 , A61K31/4439 , C07D213/643 , C07D233/72 , C07D233/76 , C07D239/22 , C07D239/47 , C07D401/04 , C07D403/04
摘要: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy.
摘要翻译: 本发明提供式(Ia)化合物及其药学上可接受的盐。 本发明还提供了化合物或盐作为Kv3.1和/或Kv3.2的调节剂的用途,以及用于治疗需要Kv3.1和/或Kv3.2调节剂的疾病或病症,例如抑郁症 情绪障碍,听觉障碍,精神分裂症,物质滥用障碍,睡眠障碍或癫痫。
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公开(公告)号:US20120289526A1
公开(公告)日:2012-11-15
申请号:US13515097
申请日:2010-12-06
申请人: Giuseppe Alvaro , Anne Décor , Stefano Fontana , Dieter Hamprecht , Charles Large , Agostino Marasco
发明人: Giuseppe Alvaro , Anne Décor , Stefano Fontana , Dieter Hamprecht , Charles Large , Agostino Marasco
IPC分类号: A61K31/4439 , C07D401/04 , A61K31/4166 , C07D403/04 , A61K31/506 , A61P25/20 , A61P25/00 , A61P27/16 , A61P25/18 , A61P25/30 , A61P25/08 , C07D233/72 , A61P25/24
CPC分类号: A61K31/506 , A61K31/4166 , A61K31/4439 , C07D213/643 , C07D233/72 , C07D233/76 , C07D239/22 , C07D239/47 , C07D401/04 , C07D403/04
摘要: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy.
摘要翻译: 本发明提供式(Ia)化合物及其药学上可接受的盐。 本发明还提供了化合物或盐作为Kv3.1和/或Kv3.2的调节剂的用途,以及用于治疗需要Kv3.1和/或Kv3.2调节剂的疾病或病症,例如抑郁症 情绪障碍,听觉障碍,精神分裂症,物质滥用障碍,睡眠障碍或癫痫。
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