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公开(公告)号：US20070027422A1
公开(公告)日：2007-02-01
申请号：US11494325
申请日：2006-07-25
申请人： Carlos Becerra , William Chandler , Scott Powers , Abebaw Zeleke
发明人： Carlos Becerra , William Chandler , Scott Powers , Abebaw Zeleke
IPC分类号： A61F5/00
CPC分类号： A61F5/04 , A61H1/0218 , A61H1/0222 , A61H1/0296 , A61H2201/018 , A61H2201/1607 , A61H2203/0493
摘要： A cervical traction device includes a base, a cervical force application member, and a motor operably attached to the cervical force application member. The motor preferably drives the cervical application member through a friction drive system in order to provide a force to a person's cervical vertebrae. The friction drive system provides overload protection to prevent application of excessive traction forces to the patient.
摘要翻译： 颈椎牵引装置包括基部，颈部力施加构件和可操作地附接到子宫颈力施加构件的马达。 电动机优选地通过摩擦驱动系统驱动子宫颈施用构件，以向人的颈椎提供力。 摩擦驱动系统提供过载保护，以防止对患者施加过大的牵引力。
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公开(公告)号：US08158163B2
公开(公告)日：2012-04-17
申请号：US12658116
申请日：2010-02-01
IPC分类号： A01N65/00
CPC分类号： A61K36/48 , A61K31/015 , A61K31/045 , A61K31/14 , A61K31/20 , A61K33/40 , A61K35/12 , A61K36/752 , A61K36/886 , A61K36/889 , A61K2300/00
摘要： An antimicrobial and antiviral barrier composition for topical application to the proximal anterior nares includes an antiseptic solution in combination with cocos nucifera (coconut oil) and one or more citrus oils such as, for example, citrus sinensis (orange oil). Various embodiments may also include one or more of the following additional ingredients: lauric acid; d-limonene; soy oil; emu oil; grapefruit seed extract; glycine soja; simmondsia chimensis (Jojoba); aloe vera; and a preservative, such as sodium benzoate, BHT, benzalkonium chloride, vitamin E.
摘要翻译： 用于局部应用于近端前鼻孔的抗微生物和抗病毒屏障组合物包括与椰子油（椰子油）和一种或多种柑橘油（例如柑橘油（橙油））组合的防腐溶液。 各种实施方案还可以包括一种或多种以下附加成分：月桂酸; d-柠檬烯 大豆油; em油 葡萄柚种子提取物; 甘氨酸大豆 西蒙（Jojoba）; 芦荟; 和防腐剂，如苯甲酸钠，BHT，苯扎氯铵，维生素E.
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公开(公告)号：US20070026085A1
公开(公告)日：2007-02-01
申请号：US11189242
申请日：2005-07-26
申请人： William Chandler
发明人： William Chandler
CPC分类号： A61K35/57 , A61K31/015 , A61K31/045 , A61K31/14 , A61K31/20 , A61K33/40 , A61K36/48 , A61K36/752 , A61K36/886 , A61K36/889 , A61K2300/00
摘要： An antimicrobial and antiviral barrier composition for topical application to the proximal anterior nares includes an antiseptic solution in combination with cocos nucifera (coconut oil) and one or more citrus oils such as, for example, citrus sinensis (orange oil). Various embodiments may also include one or more of the following additional ingredients: lauric acid; d-limonene; soy oil; emu oil; grapefruit seed extract; glycine soja; aloe vera and a preservative, such as sodium benzoate.
摘要翻译： 用于局部应用于近端前鼻孔的抗微生物和抗病毒屏障组合物包括与椰子油（椰子油）和一种或多种柑橘油（例如柑橘油（橙油））组合的防腐溶液。 各种实施方案还可以包括一种或多种以下附加成分：月桂酸; d-limonene; 大豆油; em油 葡萄柚种子提取物; 甘氨酸大豆 芦荟和防腐剂，如苯甲酸钠。
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公开(公告)号：US20100215784A1
公开(公告)日：2010-08-26
申请号：US12658116
申请日：2010-02-01
IPC分类号： A01N65/42
CPC分类号： A61K36/48 , A61K31/015 , A61K31/045 , A61K31/14 , A61K31/20 , A61K33/40 , A61K35/12 , A61K36/752 , A61K36/886 , A61K36/889 , A61K2300/00
摘要： An antimicrobial and antiviral barrier composition for topical application to the proximal anterior nares includes an antiseptic solution in combination with cocos nucifera (coconut oil) and one or more citrus oils such as, for example, citrus sinensis (orange oil). Various embodiments may also include one or more of the following additional ingredients: lauric acid; d-limonene; soy oil; emu oil; grapefruit seed extract; glycine soja; simmondsia chimensis (Jojoba); aloe vera; and a preservative, such as sodium benzoate, BHT, benzalkonium chloride, vitamin E.
摘要翻译： 用于局部应用于近端前鼻孔的抗微生物和抗病毒屏障组合物包括与椰子油（椰子油）和一种或多种柑橘油（例如柑橘油（橙油））组合的防腐溶液。 各种实施方案还可以包括一种或多种以下附加成分：月桂酸; d-limonene; 大豆油; em油 葡萄柚种子提取物; 甘氨酸大豆 西蒙（Jojoba）; 芦荟; 和防腐剂，如苯甲酸钠，BHT，苯扎氯铵，维生素E.
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公开(公告)号：US20090004305A1
公开(公告)日：2009-01-01
申请号：US12148967
申请日：2008-04-23
申请人： William Chandler
发明人： William Chandler
IPC分类号： A61K36/752
CPC分类号： A61K35/57 , A61K31/015 , A61K31/045 , A61K31/14 , A61K31/20 , A61K33/40 , A61K36/48 , A61K36/752 , A61K36/886 , A61K36/889 , A61K2300/00
摘要： An antimicrobial and antiviral barrier composition for topical application to the proximal anterior nares includes an antiseptic solution in combination with Cocos nucifera (coconut oil) and one or more citrus oils such as, for example, Citrus sinensis (orange oil). Various embodiments may also include one or more of the following additional ingredients: lauric acid; d-limonene; soy oil; emu oil; grapefruit seed extract; glycine soja; aloe vera and a preservative, such as sodium benzoate.
摘要翻译： 用于局部应用于近端前鼻孔的抗微生物和抗病毒屏障组合物包括与椰子（Cocos nucifera）（椰子油）和一种或多种柑橘油（例如柑橘油（橙色油））结合的防腐溶液。 各种实施方案还可以包括一种或多种以下附加成分：月桂酸; d-limonene; 大豆油; em油 葡萄柚种子提取物; 甘氨酸大豆 芦荟和防腐剂，如苯甲酸钠。
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公开(公告)号：US07638147B2
公开(公告)日：2009-12-29
申请号：US12148967
申请日：2008-04-23
申请人： William Chandler
发明人： William Chandler
IPC分类号： A01N65/00
CPC分类号： A61K35/57 , A61K31/015 , A61K31/045 , A61K31/14 , A61K31/20 , A61K33/40 , A61K36/48 , A61K36/752 , A61K36/886 , A61K36/889 , A61K2300/00
摘要： An antimicrobial and antiviral barrier composition for topical application to the proximal anterior nares includes an antiseptic solution in combination with cocos nucifera (coconut oil) and one or more citrus oils such as, for example, citrus sinensis (orange oil). Various embodiments may also include one or more of the following additional ingredients: lauric acid; d-limonene; soy oil; emu oil; grapefruit seed extract; glycine soja; aloe vera and a preservative, such as sodium benzoate.
摘要翻译： 用于局部应用于近端前鼻孔的抗微生物和抗病毒屏障组合物包括与椰子油（椰子油）和一种或多种柑橘油（例如柑橘油（橙油））组合的防腐溶液。 各种实施方案还可以包括一种或多种以下附加成分：月桂酸; d-limonene; 大豆油; em油 葡萄柚种子提取物; 甘氨酸大豆 芦荟和防腐剂，如苯甲酸钠。
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公开(公告)号：US20090011042A1
公开(公告)日：2009-01-08
申请号：US11906640
申请日：2007-10-03
CPC分类号： A61K36/48 , A61K31/015 , A61K31/045 , A61K31/14 , A61K31/20 , A61K33/40 , A61K35/12 , A61K36/752 , A61K36/886 , A61K36/889 , A61K2300/00
摘要： An antimicrobial and antiviral barrier composition for topical application to the proximal anterior nares includes an antiseptic solution in combination with cocos nucifera (coconut oil) and one or more citrus oils such as, for example, citrus sinensis (orange oil). Various embodiments may also include one or more of the following additional ingredients: lauric acid; d-limonene; soy oil; emu oil; grapefruit seed extract; glycine soja; simmondsia chimensis (Jojoba); aloe vera; and a preservative, such as sodium benzoate, BHT, benzalkonium chloride, vitamin E.
摘要翻译： 用于局部应用于近端前鼻孔的抗微生物和抗病毒屏障组合物包括与椰子油（椰子油）和一种或多种柑橘油（例如柑橘油（橙油））组合的防腐溶液。 各种实施方案还可以包括一种或多种以下附加成分：月桂酸; d-limonene; 大豆油; em油 葡萄柚种子提取物; 甘氨酸大豆 西蒙（Jojoba）; 芦荟; 和防腐剂，如苯甲酸钠，BHT，苯扎氯铵，维生素E.
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公开(公告)号：US20070077663A1
公开(公告)日：2007-04-05
申请号：US11604601
申请日：2006-11-27
申请人： Christopher Goh , Keith Hall , Thomas Boussie , Vince Murphy , Trevor Frank , William Chandler , Lynn Van Erden
发明人： Christopher Goh , Keith Hall , Thomas Boussie , Vince Murphy , Trevor Frank , William Chandler , Lynn Van Erden
CPC分类号： B01J3/04 , B01J19/0046 , B01J2219/00283 , B01J2219/00315 , B01J2219/00353 , B01J2219/00477 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00601 , B01J2219/00689 , B01J2219/00698 , B01J2219/00722 , B01J2219/00738 , C40B40/14 , C40B50/08 , C40B60/14 , Y10T436/2575
摘要： An apparatus and method for injection of one or more chemical components into a reaction chamber are disclosed. The apparatus includes a reaction chamber for receiving one or more libraries in a fixed position relative to the chamber and configured to form a sealed enclosure. An injection manifold is located within the reaction chamber and selectively movable relative to the libraries. The injection manifold is configured for receiving at least one fluid transfer line coupled to an external source for injection of one or more chemical components into the reaction chamber.
摘要翻译： 公开了将一种或多种化学成分注入反应室的装置和方法。 该装置包括反应室，用于接收相对于室的固定位置的一个或多个库，并构造成形成密封的外壳。 注射歧管位于反应室内并且可相对于库选择性地移动。 注入歧管被构造成用于接收至少一个连接到外部源的流体输送管线，用于将一种或多种化学成分注入反应室。
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9.发明申请Apparatuses and methods for creating and testing pre-formulations and systems for same 审中-公开用于创建和测试预配制和相同系统的设备和方法公开(公告)号：US20070077657A1
公开(公告)日：2007-04-05
申请号：US11389621
申请日：2006-03-24
申请人： Eric Carlson , Peijun Cong , William Chandler , Henry Chau , Earl Danielson , Peter Desrosiers , Robert Doolen , Luping Wu , C. Ramberg , Thomas Crevier , Ralph Nielsen , Colin Masui , John Varni
发明人： Eric Carlson , Peijun Cong , William Chandler , Henry Chau , Earl Danielson , Peter Desrosiers , Robert Doolen , Luping Wu , C. Ramberg , Thomas Crevier , Ralph Nielsen , Colin Masui , John Varni
IPC分类号： G01N31/00
CPC分类号： B01L3/50255 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00315 , B01J2219/00335 , B01J2219/00364 , B01J2219/00373 , B01J2219/00423 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L7/00 , B01L2300/0829 , B01L2300/185 , C40B40/04 , C40B40/10 , C40B60/10 , C40B60/14 , G01N5/045 , G01N21/23 , G01N21/65 , G01N25/04 , G01N33/15 , G01N33/54366 , G01N35/028 , G01N2013/006 , G01N2021/651 , G01N2500/00 , G16C20/20 , G16C20/90 , Y10T117/10
摘要： The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.
摘要翻译： 本发明提供了用于进行候选药物的盐和多晶型物的高通量制备和筛选的方法，装置和系统。 本发明旨在增强用于药物开发的预配制发现过程。 特别地，提供了确定基本上发现可从特定药物候选物形成的每个多晶型物的合适的盐和方法的方法。 使用特定配置为在高吞吐量表征过程中执行各种步骤的几个装置来执行处理。 一种这样的装置被配置为基于例如由计算机系统生成的库模型来合成多个库成员。 另一种装置可以过滤合成的溶液以提供可以进行盐或多晶型测试的基本上纯的混合物。 可以使用另一种装置将混合物在基底上结晶，使得结晶的混合物可以被一个或多个筛选装置筛选。
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公开(公告)号：US20050211622A1
公开(公告)日：2005-09-29
申请号：US11131277
申请日：2005-05-16
申请人： Eric Carlson , Peijun Cong , William Chandler , Peter Desrosiers , J. Freitag , John Varni
发明人： Eric Carlson , Peijun Cong , William Chandler , Peter Desrosiers , J. Freitag , John Varni
IPC分类号： G01N21/64 , B01J19/00 , B01L3/00 , B01L3/06 , B01L7/00 , C07B61/00 , C07D209/20 , C07D293/00 , C40B40/10 , C40B60/08 , C40B60/14 , G01N5/04 , G01N13/00 , G01N21/23 , G01N21/27 , G01N21/33 , G01N21/35 , G01N21/47 , G01N21/65 , G01N21/78 , G01N24/08 , G01N25/04 , G01N30/88 , G01N33/15 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/543 , G01N35/02 , G01N37/00 , B01D29/88
CPC分类号： B01L3/50255 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00315 , B01J2219/00335 , B01J2219/00364 , B01J2219/00373 , B01J2219/00423 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L7/00 , B01L2300/0829 , B01L2300/185 , C40B40/04 , C40B40/10 , C40B60/10 , C40B60/14 , G01N5/045 , G01N21/23 , G01N21/65 , G01N25/04 , G01N33/15 , G01N33/54366 , G01N35/028 , G01N2013/006 , G01N2021/651 , G01N2500/00 , G06F19/703 , G06F19/709 , Y10T117/10
摘要： The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.
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