-
1.发明申请Synthesis and application of new structural well defined branched polymers as conjugating agents for peptides 审中-公开新结构明确的支化聚合物作为肽缀合剂的合成和应用公开(公告)号：US20060182714A1
公开(公告)日：2006-08-17
申请号：US11344767
申请日：2006-02-01
申请人： Carsten Behrens , Florencio Dorwald , Mikael Kofod-Hansen , Jesper Lau , Janos Kodra , Thomas Hansen , Paw Bloch
发明人： Carsten Behrens , Florencio Dorwald , Mikael Kofod-Hansen , Jesper Lau , Janos Kodra , Thomas Hansen , Paw Bloch
CPC分类号： C12P21/005 , A61K47/549 , A61K47/60 , C12N9/6437
摘要： The invention provides synthesis and application of new structural well defined branched polymers as protraction agents for peptide and protein.
摘要翻译： 本发明提供新的结构明确的支化聚合物作为肽和蛋白质的助剂的合成和应用。
-
2.发明申请Synthesis and Application of New Structural Well Defined Branched Polymers as Conjugating Agents for Peptides 审中-公开新型结构定义的支化聚合物作为多肽共轭剂的合成与应用公开(公告)号：US20090240028A1
公开(公告)日：2009-09-24
申请号：US12276885
申请日：2008-11-24
申请人： Carsten Behrens , Florencio Zaragoza Dorwald , Mikael Kofod-Hansen , Jesper Lau , Janos Tibor Kodra , Thomas Kruse Hansen , Paw Bloch
发明人： Carsten Behrens , Florencio Zaragoza Dorwald , Mikael Kofod-Hansen , Jesper Lau , Janos Tibor Kodra , Thomas Kruse Hansen , Paw Bloch
IPC分类号： C07K14/00
CPC分类号： C12P21/005 , A61K47/549 , A61K47/60 , C12N9/6437
摘要： The invention provides synthesis and application of new structural well defined branched polymers as protraction agents for peptide and protein.
摘要翻译： 本发明提供新的结构明确的支化聚合物作为肽和蛋白质的助剂的合成和应用。
-
3.发明申请Insulin Derivatives Conjugated with Structurally Well Defined Branched Polymers 审中-公开与结构定义良好的支化聚合物共轭的胰岛素衍生物公开(公告)号：US20090036353A1
公开(公告)日：2009-02-05
申请号：US11814184
申请日：2006-01-26
申请人： Carsten Behrens , Jesper Lau , Janos Tibor Kodra , Mikael Kofod-Hansen , Thomas Hoeg-Jensen , Peter Madsen , Svend Havelund
发明人： Carsten Behrens , Jesper Lau , Janos Tibor Kodra , Mikael Kofod-Hansen , Thomas Hoeg-Jensen , Peter Madsen , Svend Havelund
CPC分类号： B82Y5/00 , A61K47/59 , A61K47/595 , A61K47/60 , A61K47/641 , A61K47/6949
摘要： Insulin conjugated with structurally well defined, bifurcated and trifurcated polymers can be use by pulmonary delivery for systemic absorption through the lungs to reduce or eliminate the need for administering other insulins by injection.
摘要翻译： 与结构良好定义的分叉和三化聚合物结合的胰岛素可以通过肺部递送用于通过肺的全身吸收，以减少或消除通过注射施用其它胰岛素的需要。
-
公开(公告)号：US20120093840A1
公开(公告)日：2012-04-19
申请号：US13262178
申请日：2010-04-06
申请人： Henrik Østergaard , Anthony Pusateri , Thomas R. Barnett , Jens Buchardt , Bernd Peschke , Mikael Kofod-Hansen , Magali A. Zundel , Carsten Behrens , Eva H. Norling Olsen , Henning Stennicke
发明人： Henrik Østergaard , Anthony Pusateri , Thomas R. Barnett , Jens Buchardt , Bernd Peschke , Mikael Kofod-Hansen , Magali A. Zundel , Carsten Behrens , Eva H. Norling Olsen , Henning Stennicke
CPC分类号： C07K14/755 , A61K38/00 , C07K16/18 , C07K2317/24 , C07K2319/30 , C07K2319/31 , C07K2319/33
摘要： The invention described herein relates to novel molecules and polypeptides comprising at least one amino acid sequence having significant identity with (homology to) human Factor VIII or biologically active portion(s) thereof, related molecules (such as nucleic acids encoding such polypeptides), compositions (such as pharmaceutical formulations) comprising such polypeptides, and methods of making and using such polypeptides.
摘要翻译： 本文所述的本发明涉及新型分子和多肽，其包含至少一个与人因子VIII或其生物活性部分（相同的分子）（例如编码这种多肽的核酸）具有同源性的同一性的氨基酸序列，组合物 （例如药物制剂），以及制备和使用这些多肽的方法。
-
公开(公告)号：US20130337537A1
公开(公告)日：2013-12-19
申请号：US13982360
申请日：2012-03-02
申请人： Ida Hilden , Bernd Peschke , Jens Breinholt , Mikael Kofod-Hansen
发明人： Ida Hilden , Bernd Peschke , Jens Breinholt , Mikael Kofod-Hansen
IPC分类号： C12N9/96
摘要： The current invention relates to: procoagulant proteins which may, for example, be fusion proteins or chemical conjugates; methods of producing said procoagulant proteins; polynucleotides that encode said fusion proteins and cells that expresses them. Furthermore, the current invention relates to procoagulant proteins for use as a medicament. Individuals that have a coagulopathy, such as haemophilia A and B with or without inhibitors, may be treated with the procoagulant proteins of the current invention.
摘要翻译： 本发明涉及：促凝血蛋白，其可以是例如融合蛋白或化学结合物; 生产所述促凝血蛋白的方法; 编码所述融合蛋白的多核苷酸和表达它们的细胞。 此外，本发明涉及用作药物的促凝血蛋白。 具有凝血病的个体，例如具有或不具有抑制剂的血友病A和B，可用本发明的促凝血蛋白进行治疗。
-
公开(公告)号：US08859731B2
公开(公告)日：2014-10-14
申请号：US13638802
申请日：2011-04-12
IPC分类号： A61K38/37 , A61K38/36 , C07K14/745 , C07K14/755 , A61K47/48 , B82Y5/00 , C07K1/107 , A61K38/00
CPC分类号： C07K14/755 , A61K38/00 , A61K47/548 , A61K47/60 , A61K47/643 , A61K47/65 , A61K47/66 , B82Y5/00 , C07K1/1077
摘要： A method of selectively introducing a substituent into a protein proximal to a binding site on the protein for a homing peptide, comprising: (a) contacting the protein with a compound comprising a homing peptide having the ability to bind to the binding site of the protein; and (b) allowing a moiety on the protein proximal to the binding site to react with the compound comprising the homing peptide, thereby to transfer the substituent G onto the protein.
摘要翻译： 选择性地将取代基引入到用于归巢肽的蛋白质上的结合位点附近的蛋白质中的方法，包括：（a）使所述蛋白质与包含具有结合蛋白质结合位点的能力的归巢肽的化合物接触 ; 和（b）使得接近结合位点的蛋白质上的部分与包含归巢肽的化合物反应，从而将取代基G转移到蛋白质上。
-
公开(公告)号：US20130071383A1
公开(公告)日：2013-03-21
申请号：US13638802
申请日：2011-04-12
IPC分类号： C07K1/00 , C07K14/745 , C07K14/61 , A61K38/27 , C07K14/52 , A61K38/00 , A61K39/395 , C07K16/00 , C07K14/755
CPC分类号： C07K14/755 , A61K38/00 , A61K47/548 , A61K47/60 , A61K47/643 , A61K47/65 , A61K47/66 , B82Y5/00 , C07K1/1077
摘要： A method of selectively introducing a substituent into a protein proximal to a binding site on the protein for a homing peptide, comprising: (a) contacting the protein with a compound comprising a homing peptide having the ability to bind to the binding site of the protein; and (b) allowing a moiety on the protein proximal to the binding site to react with the compound comprising the homing peptide, thereby to transfer the substituent G onto the protein.
摘要翻译： 选择性地将取代基引入到用于归巢肽的蛋白质上的结合位点附近的蛋白质中的方法，包括：（a）使所述蛋白质与包含具有结合蛋白质结合位点的能力的归巢肽的化合物接触 ; 和（b）使得接近结合位点的蛋白质上的部分与包含归巢肽的化合物反应，从而将取代基G转移到蛋白质上。
-
公开(公告)号：US20130040888A1
公开(公告)日：2013-02-14
申请号：US13574142
申请日：2011-02-02
申请人： Bernd Peschke , Mikael Kofod-Hansen , Jens Buchardt , Henning Ralf Stennicke , Henrik Oestergaard , Marianne Kjalke , Eva H. Norling Olsen , Jens Jacob Hansen
发明人： Bernd Peschke , Mikael Kofod-Hansen , Jens Buchardt , Henning Ralf Stennicke , Henrik Oestergaard , Marianne Kjalke , Eva H. Norling Olsen , Jens Jacob Hansen
IPC分类号： C07K14/755 , A61P7/04 , A61K38/37 , C07K19/00 , C07K1/107
CPC分类号： A61K38/37 , A61K38/00 , A61K39/3955 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6849 , C07K14/755
摘要： The present invention relates to a recombinant Factor VIII molecule, wherein said molecule has reduced vWF binding capacity, and wherein said molecule is covalently conjugated with at least one side group.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.035 秒)