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    Occlusion member and tensioner apparatus and methods of their use for sealing a vascular puncture
    1.
    发明授权
    Occlusion member and tensioner apparatus and methods of their use for sealing a vascular puncture 有权
    闭塞成员和张紧器设备及其用于密封血管穿刺的方法

    公开(公告)号：US07985240B2

    公开(公告)日：2011-07-26

    申请号：US11929762

    申请日：2007-10-30

    申请人： Celso J. Bagaoisan ,  Juan Domingo ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    发明人： Celso J. Bagaoisan ,  Juan Domingo ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    IPC分类号： A61B17/08

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00557 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61M25/10182 ,  A61M25/10187 ,  A61M2025/0681

    摘要： Apparatus for sealing a puncture includes an elongate occlusion member having a balloon attached to distal ends of telescoping inner and outer members. A housing on the proximal end of the outer member includes a piston coupled to the inner member and slidable within a chamber communicating with a fluid reservoir. A switch on the housing is actuated to direct fluid from the reservoir through the outer member into the balloon to expand the balloon and into the chamber to move the piston and pull the inner member, shortening the balloon as it expands. During use, the distal end of the occlusion member is introduced into a puncture communicating with a vessel until the collapsed balloon is disposed within the vessel. The balloon is expanded, and a tensioner is connected to the housing to apply a proximal force holding the balloon against the vessel wall to seal the puncture.

    摘要翻译： 用于密封穿刺的装置包括具有附接到伸缩的内部和外部构件的远端的气囊的细长闭塞构件。 外部构件的近端上的壳体包括联接到内部构件并可在与流体储存器连通的腔室内滑动的活塞。 启动壳体上的开关以将流体从储存器引导通过外部构件进入气囊，以使气囊膨胀并进入腔室中，以移动活塞并拉动内部构件，从而在气囊膨胀时缩短气囊。 在使用期间，将阻塞构件的远端引入到与血管连通的穿刺件中，直到将收缩的气囊设置在血管内。 气囊膨胀，并且张紧器连接到壳体以施加将气囊保持抵靠血管壁的近侧力以密封穿刺。

    Occlusion member and tensioner apparatus and methods of their use for sealing a vascular puncture
    2.
    发明授权
    Occlusion member and tensioner apparatus and methods of their use for sealing a vascular puncture 有权
    闭塞成员和张紧器设备及其用于密封血管穿刺的方法

    公开(公告)号：US07316704B2

    公开(公告)日：2008-01-08

    申请号：US10806927

    申请日：2004-03-22

    申请人： Celso J. Bagaoisan ,  Juan Domingo ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    发明人： Celso J. Bagaoisan ,  Juan Domingo ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    IPC分类号： A61B17/08

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00557 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61M25/10182 ,  A61M25/10187 ,  A61M2025/0681

    摘要： Apparatus for sealing a puncture includes an elongate occlusion member having a balloon attached to distal ends of telescoping inner and outer members. A housing on the proximal end of the outer member includes a piston coupled to the inner member and slidable within a chamber communicating with a fluid reservoir. A switch on the housing is actuated to direct fluid from the reservoir through the outer member into the balloon to expand the balloon and into the chamber to move the piston and pull the inner member, shortening the balloon as it expands. During use, the distal end of the occlusion member is introduced into a puncture communicating with a vessel until the collapsed balloon is disposed within the vessel. The balloon is expanded, and a tensioner is connected to the housing to apply a proximal force holding the balloon against the vessel wall to seal the puncture.

    摘要翻译： 用于密封穿刺的装置包括具有附接到伸缩的内部和外部构件的远端的气囊的细长闭塞构件。 外部构件的近端上的壳体包括联接到内部构件并可在与流体储存器连通的腔室内滑动的活塞。 启动壳体上的开关以将流体从储存器引导通过外部构件进入气囊，以使气囊膨胀并进入腔室中，以移动活塞并拉动内部构件，从而在气囊膨胀时缩短气囊。 在使用期间，将阻塞构件的远端引入到与血管连通的穿刺件中，直到将收缩的气囊设置在血管内。 气囊膨胀，并且张紧器连接到壳体以施加将气囊保持抵靠血管壁的近侧力以密封穿刺。

    Auto-retraction apparatus and methods for sealing a vascular puncture
    3.
    发明授权
    Auto-retraction apparatus and methods for sealing a vascular puncture 有权
    自动回缩装置和密封血管穿刺的方法

    公开(公告)号：US09289195B2

    公开(公告)日：2016-03-22

    申请号：US10806952

    申请日：2004-03-22

    申请人： Celso J. Bagaoisan ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    发明人： Celso J. Bagaoisan ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    IPC分类号： A61B17/08 ,  A61B17/00 ,  A61M25/10 ,  A61M25/06

    CPC分类号： A61B17/0057 ,  A61B2017/00495 ,  A61B2017/00557 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00986 ,  A61M25/1002 ,  A61M25/10182 ,  A61M25/10184 ,  A61M25/10187 ,  A61M2025/0681

    摘要： Apparatus for sealing a puncture communicating with a blood vessel includes an introducer sheath, an occlusion member with a balloon thereon, a retraction assembly, and a syringe assembly including sealing material therein. During use, the introducer sheath is introduced into the puncture. With the balloon in a collapsed state, the occlusion member is introduced through the introducer sheath until the balloon is disposed within the vessel. The introducer sheath is coupled to the retraction assembly, the balloon is expanded, and the occlusion member is partially withdrawn to seal the puncture. A sealing compound is delivered from the syringe assembly through the introducer sheath into the puncture, the syringe assembly triggering the retraction assembly, whereupon the introducer sheath is automatically withdrawn at least partially from the puncture, delivering the sealing compound along the puncture.

    摘要翻译： 用于密封与血管连通的穿刺的装置包括导引鞘，其上具有气囊的闭塞构件，收缩组件和其中包括密封材料的注射器组件。 在使用过程中，导引鞘被引入穿刺。 当气囊处于折叠状态时，闭塞构件通过引导器护套引入，直到球囊置于血管内。 引导器护套联接到缩回组件，气囊膨胀，并且闭塞构件被部分地抽出以密封穿刺。 密封化合物从注射器组件通过引导器护套输送到穿刺中，注射器组件触发缩回组件，于是引导器护套至少部分地从穿刺中自动抽出，沿着穿刺输送密封化合物。

    Auto-injector apparatus and methods for sealing a vascular puncture
    4.
    发明授权
    Auto-injector apparatus and methods for sealing a vascular puncture 有权
    自动注射装置和密封血管穿刺的方法

    公开(公告)号：US07553319B2

    公开(公告)日：2009-06-30

    申请号：US10806934

    申请日：2004-03-22

    申请人： Celso J. Bagaoisan ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    发明人： Celso J. Bagaoisan ,  Nicanor Domingo ,  Farhad Khosravi ,  Suresh S. Pai

    IPC分类号： A61B17/08 ,  A61M31/00

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00557 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61M25/10182 ,  A61M25/10187 ,  A61M2025/0681

    摘要： Apparatus for sealing a puncture communicating with a blood vessel includes a pair of syringe barrels having sealing components therein, and a plunger assembly biased to slide within the barrels from proximal to distal positions for injecting the components through outlets of the barrels. An auto-injector assembly is coupled to the plunger apparatus, and includes a spring mechanism locked in an inactive condition and an actuator activatable to release the spring mechanism, whereupon the spring mechanism automatically advances the plunger assembly towards the distal position to inject the components from the barrels. A valve coupled to the outlets and movable from a first position for mixing and/or reconstituting the sealing components from vials, a second position where the outlets communicate with a delivery line for delivering the sealing components into a puncture, and a third position for closing the outlets.

    摘要翻译： 用于密封与血管连通的穿刺的装置包括一对在其中具有密封部件的注射器筒，以及被偏置成在近端到远端位置在筒内滑动的柱塞组件，用于通过筒的出口喷射部件。 自动注射器组件联接到柱塞装置，并且包括锁定在不活动状态的弹簧机构和可激活以释放弹簧机构的致动器，于是弹簧机构自动地将柱塞组件前进到远侧位置以从 桶。 一个阀，其联接到所述出口并且可从第一位置移动，用于混合和/或重建来自小瓶的密封部件;第二位置，其中所述出口与用于将密封部件输送到穿刺部的输送管线连通;以及第三位置， 出口。

    Apparatus and methods for sealing a vascular puncture
    7.
    发明授权
    Apparatus and methods for sealing a vascular puncture 有权
    用于密封血管穿刺的装置和方法

    公开(公告)号：US08617204B2

    公开(公告)日：2013-12-31

    申请号：US11854534

    申请日：2007-09-12

    申请人： Farhad Khosravi ,  Suresh S. Pai ,  Celso J. Bagaoisan ,  Scott R. Sershen ,  Marlon Moreno ,  Juan Domingo

    发明人： Farhad Khosravi ,  Suresh S. Pai ,  Celso J. Bagaoisan ,  Scott R. Sershen ,  Marlon Moreno ,  Juan Domingo

    IPC分类号： A61B17/08

    CPC分类号： A61B17/0057 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00654

    摘要： An apparatus for sealing a puncture through tissue to a vessel includes an elongate occlusion member including an expandable member, a cartridge carried on the occlusion member, and a sealant carried within the cartridge. The cartridge includes an outer member and a pusher member within the outer member. The sealant is disposed within the outer member adjacent the expandable member distal to the pusher member. During use, the occlusion member is introduced into a puncture until the expandable member and the sealant extend from the puncture into the vessel. The expandable member is expanded, and withdrawn until the expanded expandable member contacts the vessel wall, thereby withdrawing the sealant back into the puncture. The outer member is withdrawn to expose the sealant within the puncture, while the pusher member prevents removal of the sealant, and then the cartridge, occlusion member, and pusher member are successively removed.

    摘要翻译： 用于将通过组织的穿刺密封到容器的装置包括包括可扩张构件的细长阻塞构件，承载在闭塞构件上的药筒和在药筒内承载的密封剂。 该盒在外部构件内包括外部构件和推动构件。 密封剂设置在外部构件中，邻近可推动构件远离推动构件。 在使用期间，将阻塞构件引入穿刺中，直到可膨胀构件和密封剂从穿刺件延伸到容器中。 可膨胀构件被膨胀并且被抽出直到膨胀的可膨胀构件接触血管壁，从而将密封剂抽回到穿刺中。 取出外部构件以在穿刺中露出密封剂，同时推动器构件防止密封剂的移除，然后连续地移除盒，遮挡构件和推动构件。

    Apparatus and methods for sealing a vascular puncture
    10.
    发明授权
    Apparatus and methods for sealing a vascular puncture 有权
    用于密封血管穿刺的装置和方法

    公开(公告)号：US08945178B2

    公开(公告)日：2015-02-03

    申请号：US13610849

    申请日：2012-09-11

    申请人： Suresh S. Pai ,  Celso J. Bagaoisan ,  Farhad Khosravi

    发明人： Suresh S. Pai ,  Celso J. Bagaoisan ,  Farhad Khosravi

    IPC分类号： A61B17/03 ,  A61B17/00

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00495 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00672

    摘要： Apparatus for sealing a puncture through tissue to a blood vessel includes a cartridge including a proximal end, a distal end sized for insertion into a puncture, and a lumen extending therebetween. A bioabsorbable plug is disposed within the lumen adjacent the distal end, and an anchoring element is disposed within the lumen proximal to the plug. A pusher member is disposed within the lumen for deploying the plug and anchoring element out the distal end of the cartridge. The plug may be formed from lyophilized hydrogel and the anchoring element may be formed from air-dried hydrogel, the anchoring element hydrating slower than the plug when exposed to an aqueous environment. During use, the plug and anchoring element are delivered into the puncture, the plug is cinched against the vessel wall. Protrusions on the anchoring element engage tissue surrounding the puncture to prevent proximal movement of the plug.

    摘要翻译： 用于将穿过组织的穿刺密封到血管的装置包括：盒，其包括近端，尺寸适于插入穿刺的远端以及在其间延伸的内腔。 生物可吸收塞子设置在邻近远端的内腔内，并且锚定元件设置在靠近塞子的内腔内。 推动器构件设置在内腔内，用于将插塞和锚固元件从盒的远端伸出。 塞子可以由冻干的水凝胶形成，并且锚定元件可以由空气干燥的水凝胶形成，当暴露于水性环境时，锚定元件比塞子保持缓慢。 在使用过程中，插头和锚定元件被输送到穿刺部分中，塞子紧贴在血管壁上。 锚固元件上的突起接合穿刺周围的组织，以防止插塞的近端移动。