利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

2 条记录 (耗时 0.02 秒)

    Vaccine comprising monocyte or immature myeloid cells (IMC) which were loaded with the ligand of natural killer T cell and antigen
    2.
    发明授权
    Vaccine comprising monocyte or immature myeloid cells (IMC) which were loaded with the ligand of natural killer T cell and antigen 有权
    包含单核细胞或未成熟骨髓细胞（IMC）的疫苗，其装载有天然杀伤T细胞和抗原的配体

    公开(公告)号：US09518126B2

    公开(公告)日：2016-12-13

    申请号：US12279166

    申请日：2007-11-28

    申请人： Chang-Yuil Kang ,  Hyun-Jeong Ko ,  Jung-Mi Lee ,  Yeon-Jeong Kim

    发明人： Chang-Yuil Kang ,  Hyun-Jeong Ko ,  Jung-Mi Lee ,  Yeon-Jeong Kim

    IPC分类号： A61K31/164 ,  C12N5/0786 ,  A61K39/00 ,  C07K16/32

    CPC分类号： C07K16/32 ,  A61K31/164 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/5158 ,  C12N5/0645 ,  C12N2501/999 ,  Y02A50/412 ,  Y02A50/464 ,  Y02A50/472 ,  Y02A50/476

    摘要： The present invention relates to an immuno-therapeutic and prophylactic vaccine comprising monocytes or immature myeloid cells (IMCs) loaded with the ligand of natural killer T cell and an antigen for the prevention and treatment of infectious disease or cancer, more precisely, an immuno-therapeutic and prophylactic vaccine comprising monocytes or IMCs loaded with α-galactosylceramide (αGalCer), a kind of glycolipid and a natural killer T cell ligand, and antigen. Monocytes or immature myeloid cells (IMCs) therein, which are easily obtainable, unlike dendritic cells, not only induce a significant level of cytotoxic T lymphocyte responses but also have a prophylactic and therapeutic effect on malignant tumor. Therefore, the immuno-therapeutic and prophylactic vaccine of the present invention can be effectively used as an immunotherapeutic agent.

    摘要翻译： 本发明涉及包含负载天然杀伤T细胞配体的单核细胞或未成熟骨髓细胞（IMC）的免疫治疗和预防性疫苗，以及用于预防和治疗感染性疾病或癌症的抗原，更准确地说， 包含装载有α-半乳糖神经酰胺（αGalCer），一种糖脂和天然杀伤T细胞配体的单核细胞或IMC的治疗和预防性疫苗和抗原。 与树突状细胞不同，易于获得的单核细胞或未成熟骨髓细胞（IMC）不仅诱导显着水平的细胞毒性T淋巴细胞应答，而且对恶性肿瘤具有预防和治疗作用。 因此，本发明的免疫治疗和预防性疫苗可以有效地用作免疫治疗剂。