摘要:
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要:
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要:
The present invention relates to substituted pyrazolopyridine compounds, and pharmaceutically acceptable salts or esters thereof. The present invention further relates to therapeutic uses of pharmaceutical compositions comprising the substituted pyrazolopyridine compounds, for example, in cancer and neurodegenerative diseases.
摘要:
A skid steer vehicle has a suspension that includes a control arm pivotally coupled to the vehicle chassis that is supported by a hydraulic cylinder connected to an accumulator to provide springing. A hydraulic circuit coupled to the cylinder and accumulator permit the operator to raise and lower the chassis, to lock the suspension while the vehicle is loaded, and to automatically charge or discharge the accumulator to match the cylinder pressure during loading and unloading. In this manner, when the suspension is unlocked after loading, the vehicle chassis neither rises nor falls.
摘要:
A dozer blade control system controls the position of a bulldozer blade, maintaining the blade at a constant position as the dozer travels through a worksite. The control system monitors the angle of the dozer blade with respect to the earth and when it senses that the dozer blade is tilting, it corrects the dozer blade's position by extending or retracting hydraulic cylinders that couple the dozer blade to the chassis of the crawler-tractor. When the dozer chassis pitches forwards, the blade begins to tilt forward and to drop closer to the ground. The control system senses this forward rotation of the blade and retracts the hydraulic cylinders that couple the blade to the chassis, causing the blade to return to and maintain its original position. Conversely, when the dozer chassis pitches backwards and the blade begins to tilt backward and rise higher above the ground, the control system extends the hydraulic cylinders coupling the blade to the chassis and lowers the blade, causing the blade to return to and maintain its original position with respect to the earth.
摘要:
A skid steer vehicle has a chassis with four drive wheels suspended from the chassis that are damped by four damping cylinders. An electronic controller varies the damping of the cylinders in an automatic mode, based on certain operational parameters of the vehicle, and in a manual mode in response to operator selection of a desired degree of suspension damping.
摘要:
A method for gaining consent to target advertising to and to collect data from a subject to online advertising includes providing, to the subject to online advertising at a computing device associated with the subject to online advertising, instructions for a consent dialogue window, the consent dialogue window served to the subject. The consent dialogue window is presented to the subject as an overlay to a website. The consent dialogue window includes a non-consent affirmation box, which, if affirmatively indicated, indicates to the consent server that the subject to online advertising does not consent to targeted advertising and collection of data, and a media declaration which accurately informs the subject that if any affirmative indication is made outside indicatable areas, which include, at least, the non-consent affirmation box, then the subject to online advertising consents to online advertisement and data collection from the vendor server and partner vendor servers.
摘要:
A skid steer vehicle has a suspension that includes a control arm pivotally coupled to the vehicle chassis that is supported by a hydraulic cylinder connected to an accumulator to provide springing. A hydraulic circuit coupled to the cylinder and accumulator permit the operator to raise and lower the chassis, to lock the suspension while the vehicle is loaded, and to automatically charge or discharge the accumulator to match the cylinder pressure during loading and unloading. In this manner, when the suspension is unlocked after loading, the vehicle chassis neither rises nor falls.