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1.发明申请Platinum Enhanced Alloy and Intravascular or Implantable Medical Devices Manufactured Therefrom 审中-公开铂金增强合金和血管内或植入式医疗器械公开(公告)号：US20120004718A1
公开(公告)日：2012-01-05
申请号：US12955522
申请日：2010-11-29
申请人： Charles H. Craig , Herbert R. Radisch, JR. , Thomas A. Trozera , David M. Knapp , Timothy S. Girton , Jonathan S. Stinson
发明人： Charles H. Craig , Herbert R. Radisch, JR. , Thomas A. Trozera , David M. Knapp , Timothy S. Girton , Jonathan S. Stinson
IPC分类号： A61F2/82
CPC分类号： C22C38/58 , A61L31/022 , A61L31/18 , C21D8/0226 , C21D8/0236 , C21D8/0268 , C22C5/04 , C22C38/002 , C22C38/44
摘要： A platinum enhanced radiopaque alloy particularly suitable for manufacture of implantable and/or intravascular medical devices. A stent is one preferred medical device which is a generally tubular structure that is expandable upon implantation in a vessel lumen to maintain flow therethrough. The stent is formed from the alloy which has improved radiopacity relative to present utilized stainless steel alloys. This alloy preferably contains from about 2 wt. % to about 50 wt. % platinum; from about 11 wt. % to about 18 wt. % chromium; about 5 wt. % to about 12 wt. % nickel and at least about 15 wt. % iron.
摘要翻译： 特别适用于制造可植入和/或血管内医疗器械的铂增强不透射线合金。 支架是一种优选的医疗装置，其是通常管状的结构，其可以在植入血管腔中时扩张以保持流过其中。 支架由相对于目前使用的不锈钢合金具有改善的不透射线性的合金形成。 该合金优选含有约2重量％ ％至约50wt。 ％铂 约11wt。 ％至约18wt。 ％铬; 约5wt。 ％至约12wt。 ％镍和至少约15wt。 ％铁。
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2.发明申请Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface 审中-公开支架设计允许药物的扩展释放和/或增强的聚合物粘附到OD表面公开(公告)号：US20100145437A1
公开(公告)日：2010-06-10
申请号：US12706881
申请日：2010-02-17
申请人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuchling
发明人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuchling
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2210/0076 , A61F2220/0066 , A61F2220/0083 , A61F2250/0067 , A61F2250/0068
摘要： The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields.
摘要翻译： 本发明涉及减少治疗剂从支架分层的机制和方法。 这些机构包括孔（通道，孔和其他孔构造），突起，烧结金属芯，夹/钉，销和不锈钢屏蔽。
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3.发明申请Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface 审中-公开支架设计允许药物的扩展释放和/或增强的聚合物粘附到OD表面公开(公告)号：US20090076591A1
公开(公告)日：2009-03-19
申请号：US11857736
申请日：2007-09-19
申请人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuehling
发明人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuehling
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2210/0076 , A61F2220/0066 , A61F2220/0083 , A61F2250/0067 , A61F2250/0068
摘要： The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields.
摘要翻译： 本发明涉及减少治疗剂从支架分层的机制和方法。 这些机构包括孔（通道，孔和其他孔构造），突起，烧结金属芯，夹/钉，销和不锈钢屏蔽。
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公开(公告)号：US08013203B2
公开(公告)日：2011-09-06
申请号：US11937338
申请日：2007-11-08
CPC分类号： C07F5/025 , C07C45/68 , C07C51/353 , C07C67/343 , C07D213/55 , C07D307/81 , C07F5/02 , C07F5/04 , Y02P20/55
摘要： A protected organoboronic acid includes a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. A method of performing a chemical reaction includes contacting a protected organoboronic acid with a reagent, the protected organoboronic acid including a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. The organic group is chemically transformed, and the boron is not chemically transformed.
摘要翻译： 受保护的有机硼酸包括具有sp 3杂交的硼，与硼结合的构象刚性保护基，以及通过硼 - 碳键与硼结合的有机基团。 进行化学反应的方法包括使受保护的有机硼酸与试剂接触，被保护的有机硼酸包括具有sp3杂交的硼，与硼结合的构象刚性保护基，和通过硼键合到硼上的有机基团 碳键。 有机基团被化学转化，并且硼不被化学转化。
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公开(公告)号：US20110201806A1
公开(公告)日：2011-08-18
申请号：US13030833
申请日：2011-02-18
IPC分类号： C07F5/04
CPC分类号： C07F5/025
摘要： Described are methods of forming protected boronic acids that provide in a manner that is straightforward, scalable, and cost-effective a wide variety of building blocks, such as building blocks containing complex and/or pharmaceutically important structures, and/or provide simple or complex protected organoboronic acid building blocks. A first method includes reacting an imino-di-carboxylic acid and an organoboronate salt. A second method includes reacting a N-substituted morpholine dione and an organoboronic acid.
摘要翻译： 描述了形成受保护的硼酸的方法，其以直接，可扩展和成本有效的方式提供各种构建块，例如含有复合物和/或药学上重要的结构的构件，和/或提供简单或复杂的 保护有机硼酸结构单元。 第一种方法包括使亚氨基二羧酸和有机硼酸盐反应。 第二种方法包括使N-取代的吗啉二酮与有机硼酸反应。
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公开(公告)号：US20120059184A1
公开(公告)日：2012-03-08
申请号：US13190223
申请日：2011-07-25
IPC分类号： C07F5/04
CPC分类号： C07F5/025 , C07C45/68 , C07C51/353 , C07C67/343 , C07D213/55 , C07D307/81 , C07F5/02 , C07F5/04 , Y02P20/55
摘要： A protected organoboronic acid includes a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. A method of performing a chemical reaction includes contacting a protected organoboronic acid with a reagent, the protected organoboronic acid including a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. The organic group is chemically transformed, and the boron is not chemically transformed.
摘要翻译： 受保护的有机硼酸包括具有sp 3杂交的硼，与硼结合的构象刚性保护基，以及通过硼 - 碳键与硼结合的有机基团。 进行化学反应的方法包括使受保护的有机硼酸与试剂接触，被保护的有机硼酸包括具有sp3杂交的硼，与硼结合的构象刚性保护基，和通过硼键合到硼上的有机基团 碳键。 有机基团被化学转化，并且硼不被化学转化。
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公开(公告)号：US09353131B2
公开(公告)日：2016-05-31
申请号：US14035408
申请日：2013-09-24
IPC分类号： C07F5/02
CPC分类号： C07F5/025
摘要： Described are methods of forming protected boronic acids that provide in a manner that is straightforward, scalable, and cost-effective a wide variety of building blocks, such as building blocks containing complex and/or pharmaceutically important structures, and/or provide simple or complex protected organoboronic acid building blocks. A first method includes reacting an imino-di-carboxylic acid and an organoboronate salt. A second method includes reacting a N-substituted morpholine dione and an organoboronic acid.
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公开(公告)号：US20140073785A1
公开(公告)日：2014-03-13
申请号：US14035408
申请日：2013-09-24
IPC分类号： C07F5/02
CPC分类号： C07F5/025
摘要： Described are methods of forming protected boronic acids that provide in a manner that is straightforward, scalable, and cost-effective a wide variety of building blocks, such as building blocks containing complex and/or pharmaceutically important structures, and/or provide simple or complex protected organoboronic acid building blocks. A first method includes reacting an imino-di-carboxylic acid and an organoboronate salt. A second method includes reacting a N-substituted morpholine dione and an organoboronic acid.
摘要翻译： 描述了形成受保护的硼酸的方法，其以直接，可扩展和成本有效的方式提供各种构建块，例如含有复合物和/或药学上重要的结构的构件，和/或提供简单或复杂的 保护有机硼酸结构单元。 第一种方法包括使亚氨基二羧酸和有机硼酸盐反应。 第二种方法包括使N-取代的吗啉二酮与有机硼酸反应。
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公开(公告)号：US08338601B2
公开(公告)日：2012-12-25
申请号：US12567443
申请日：2009-09-25
申请人： Martin D. Burke , David M. Knapp , Eric P Gillis
发明人： Martin D. Burke , David M. Knapp , Eric P Gillis
IPC分类号： C07F5/02 , C07D213/57
CPC分类号： C07D413/04 , C07B61/00 , C07C1/321 , C07C41/30 , C07C2527/173 , C07C2531/12 , C07C2531/24 , C07C2601/02 , C07D207/325 , C07D207/333 , C07D207/34 , C07D209/12 , C07D209/30 , C07D213/16 , C07D213/50 , C07D213/57 , C07D213/73 , C07D241/42 , C07D263/56 , C07D307/36 , C07D307/42 , C07D307/80 , C07D333/16 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , Y02P20/55 , C07C15/46 , C07C15/58 , C07C13/28 , C07C43/2055
摘要： A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1—B-T (I); where R1 represents an organic group, T represents a conformationally rigid protecting group, and B represents boron having sp3 hybridization. When unprotected, the corresponding organoboronic acid is unstable by the boronic acid neat stability test. The reaction mixture further includes a base having a pKB of at least 1 and a palladium catalyst. The method further includes forming a cross-coupled product in the reaction mixture.
摘要翻译： 一种进行化学反应的方法包括在反应混合物中将选自有机卤化物和有机卤化物的化合物与由式（I）表示的被保护的有机硼酸反应：R1-B-T（I）; 其中R1表示有机基团，T表示构象刚性保护基团，B表示具有sp3杂交的硼。 当不受保护时，相应的有机硼酸通过硼酸纯稳定性试验不稳定。 反应混合物还包括具有至少1的pKB的碱和钯催化剂。 该方法还包括在反应混合物中形成交叉偶联产物。
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公开(公告)号：US20100121062A1
公开(公告)日：2010-05-13
申请号：US12567443
申请日：2009-09-25
申请人： Martin D. Burke , David M. Knapp , Eric P. Gillis
发明人： Martin D. Burke , David M. Knapp , Eric P. Gillis
IPC分类号： C07D409/04 , C07D405/04 , C07D401/04 , C07D213/57 , C07D213/50 , C07D413/10 , C07D209/12 , C07D207/46 , C07D333/16 , C07D307/80 , C07D307/42 , C07D307/36 , C07C49/792 , C07C43/21 , C07C43/205 , C07C15/46 , C07C13/04
CPC分类号： C07D413/04 , C07B61/00 , C07C1/321 , C07C41/30 , C07C2527/173 , C07C2531/12 , C07C2531/24 , C07C2601/02 , C07D207/325 , C07D207/333 , C07D207/34 , C07D209/12 , C07D209/30 , C07D213/16 , C07D213/50 , C07D213/57 , C07D213/73 , C07D241/42 , C07D263/56 , C07D307/36 , C07D307/42 , C07D307/80 , C07D333/16 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , Y02P20/55 , C07C15/46 , C07C15/58 , C07C13/28 , C07C43/2055
摘要： A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1—B-T (I); where R1 represents an organic group, T represents a conformationally rigid protecting group, and B represents boron having sp3 hybridization. When unprotected, the corresponding organoboronic acid is unstable by the boronic acid neat stability test. The reaction mixture further includes a base having a pKB of at least 1 and a palladium catalyst. The method further includes forming a cross-coupled product in the reaction mixture.
摘要翻译： 一种进行化学反应的方法包括使反应混合物中R1-B-T（Ⅰ）; R1-B-T（Ⅰ）反应，使选自有机卤化物和有机卤化物的化合物与式（I）表示的被保护的有机硼酸反应。 其中R1表示有机基团，T表示构象刚性保护基团，B表示具有sp3杂交的硼。 当不受保护时，相应的有机硼酸通过硼酸纯稳定性试验不稳定。 反应混合物还包括具有至少1的pKB的碱和钯催化剂。 该方法还包括在反应混合物中形成交叉偶联产物。
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