公开(公告)号：US11773091B2

公开(公告)日：2023-10-03

申请号：US17735283

申请日：2022-05-03

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen Fan ,  Christopher W. Lange ,  Rebecca M. Lui ,  Viengkham Malathong ,  Venkat Reddy Mali ,  Sreenivas Punna ,  Rajinder Singh ,  Hiroko Tanaka ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D471/04 ,  A61P37/02 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61P37/02 ,  C07D519/00

摘要： The present disclosure provides, inter alia, Compounds of Formula (I)




or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US11713307B2

公开(公告)日：2023-08-01

申请号：US17071077

申请日：2020-10-15

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen Fan ,  Christopher W. Lange ,  Rebecca M. Lui ,  Darren J. McMurtrie ,  Ryan J. Scamp ,  Ju Yang ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D487/10

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D403/14 ,  C07D405/14 ,  C07D487/10

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I)




including stereoisomers and pharmaceutically acceptable salts thereof, wherein R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US10786494B2

公开(公告)日：2020-09-29

申请号：US16150796

申请日：2018-10-03

申请人： CHEMOCENTRYX, INC.

发明人： Daniel Dairaghi ,  Dean R. Dragoli ,  Jaroslaw Kalisiak ,  Christopher W. Lange ,  Manmohan Reddy Leleti ,  Yandong Li ,  Rebecca M. Lui ,  Venkat Reddy Mali ,  Viengkham Malathong ,  Jay P. Powers ,  Hiroko Tanaka ,  Joanne Tan ,  Matthew J. Walters ,  Ju Yang ,  Penglie Zhang

IPC分类号： A61K31/47 ,  C07D215/48 ,  C07D405/04 ,  C07D405/14 ,  A61K31/4709

摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:

公开(公告)号：US10759807B2

公开(公告)日：2020-09-01

申请号：US16226898

申请日：2018-12-20

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen Fan ,  Christopher W. Lange ,  Rebecca M. Lui ,  Viengkham Malathong ,  Venkat Reddy Mali ,  Sreenivas Punna ,  Rajinder Singh ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D487/04 ,  A61K9/00 ,  A61K45/06 ,  A61K31/4162 ,  A61P35/00 ,  A61P19/02 ,  A61P11/00 ,  A61P25/28 ,  A61P37/06 ,  A61P7/00 ,  A61K9/10 ,  A61K9/08

摘要： The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US20160340356A1

公开(公告)日：2016-11-24

申请号：US15158713

申请日：2016-05-19

申请人： CHEMOCENTRYX, INC.

发明人： Junfa Fan ,  Jaroslaw Kalisiak ,  Rebecca M. Lui ,  Venkat Reddy Mali ,  Jeffrey P. McMahon ,  Jay P. Powers ,  Hiroko Tanaka ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D471/04 ,  C07D405/04 ,  A61K31/453 ,  A61K31/4725 ,  C07D413/14 ,  A61K31/536 ,  C07D405/14 ,  A61K31/4545 ,  A61K31/496

CPC分类号： C07D471/04 ,  A61K31/453 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/536 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14

摘要： Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I): and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of CCR2 receptors.

摘要翻译： 并且可用于药物组合物，用于治疗涉及CCR2受体的病理性激活的疾病和病症的方法。

公开(公告)号：US20160145259A1

公开(公告)日：2016-05-26

申请号：US14836172

申请日：2015-08-26

申请人： ChemoCentryx, Inc.

发明人： Junfa FAN ,  Antoni Krasinski ,  Christopher W. Lange ,  Rebecca M. Lui ,  Jeffrey P. McMahon ,  Jay P. Powers ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D487/04 ,  G01N33/574 ,  A61K51/04

CPC分类号： C07D487/04 ,  A61K51/0459 ,  G01N33/57492 ,  G01N2333/7158

摘要： Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.

摘要翻译： 提供具有式I化合物或其药学上可接受的盐，水合物或N-氧化物，并且可用于结合CXCR7，并且治疗至少部分依赖于CXCR7活性的疾病。 因此，本发明还提供含有一种或多种上述化合物与药学上可接受的赋形剂混合的组合物。

公开(公告)号：US09340509B2

公开(公告)日：2016-05-17

申请号：US14557949

申请日：2014-12-02

申请人： ChemoCentryx, Inc.

发明人： Daniel Dairaghi ,  Dean R. Dragoli ,  Jarek Kalisiak ,  Christopher W. Lange ,  Manmohan Reddy Leleti ,  Yandong Li ,  Rebecca M. Lui ,  Venkat Reddy Mali ,  Viengkham Malathong ,  Jay P. Powers ,  Hiroko Tanaka ,  Joanne Tan ,  Matthew J. Walters ,  Ju Yang ,  Penglie Zhang

IPC分类号： C07D215/48 ,  C07D405/14 ,  C07D405/04

CPC分类号： A61K31/47 ,  A61K31/4709 ,  C07D215/48 ,  C07D405/04 ,  C07D405/14

摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:

摘要翻译： 提供式（I）化合物，其可用于治疗至少部分由CCR6调节的疾病或病症：

公开(公告)号：US12054484B2

公开(公告)日：2024-08-06

申请号：US17357427

申请日：2021-06-24

申请人： CHEMOCENTRYX, INC.

发明人： Junfa Fan ,  Jaroslaw Kalisiak ,  Rebecca M. Lui ,  Venkat Reddy Mali ,  Jeffrey P. McMahon ,  Jay P. Powers ,  Hiroko Tanaka ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： A61K31/35 ,  A61K31/453 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/536 ,  A61K31/538 ,  A61K31/551 ,  A61K31/553 ,  A61K45/06 ,  A61P35/00 ,  A61P37/00 ,  C07D309/24 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D471/04 ,  A61K31/453 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/536 ,  A61K31/538 ,  A61K31/551 ,  A61K31/553 ,  A61K45/06 ,  A61P35/00 ,  A61P37/00 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14

摘要： Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (Ia1′):




and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of CCR2 receptors.

公开(公告)号：US10759789B2

公开(公告)日：2020-09-01

申请号：US16524618

申请日：2019-07-29

申请人： CHEMOCENTRYX, INC.

发明人： Xi Chen ,  Dean R. Dragoli ,  Pingchen Fan ,  Manmohan Reddy Leleti ,  Rebecca M. Lui ,  Viengkham Malathong ,  Jay P. Powers ,  Rajinder Singh ,  Hiroko Tanaka ,  Ju Yang ,  Chao Yu ,  Penglie Zhang

IPC分类号： A61K31/404 ,  A61K31/4439 ,  C07D405/14 ,  C07D405/04 ,  C07D401/04 ,  C07D209/34 ,  A61P1/00 ,  A61P19/00 ,  A61P17/00 ,  A61P35/00 ,  A61P11/00

摘要： Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.

公开(公告)号：US10683294B2

公开(公告)日：2020-06-16

申请号：US15991747

申请日：2018-05-29

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen Fan ,  Christopher W. Lange ,  Rebecca M. Lui ,  Viengkham Malathong ,  Venkat Reddy Mali ,  Sreenivas Punna ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D487/04 ,  A61P37/02

摘要： The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.