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1.Benzofuran derivatives useful for treating hyper-proliferative disorders 失效
标题翻译: 可用于治疗高增殖性疾病的苯并呋喃衍生物公开(公告)号:US07659412B2
公开(公告)日:2010-02-09
申请号:US12201547
申请日:2008-08-29
申请人: Chengzhi Zhang , Jacques Dumas , Gaetan Ladouceur , Qian Zhao , Martin Hentemann , Sharad Verma , Qingming Zhu , Rico Lavoie , Jianmei Fan , Barton Phillips
发明人: Chengzhi Zhang , Jacques Dumas , Gaetan Ladouceur , Qian Zhao , Martin Hentemann , Sharad Verma , Qingming Zhu , Rico Lavoie , Jianmei Fan , Barton Phillips
IPC分类号: C07D307/87 , A61K31/34
CPC分类号: C07D307/83 , C07D307/80 , C07D307/81 , C07D307/82 , C07D405/04
摘要: The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
摘要翻译: 本发明涉及新的苯并呋喃衍生物,其制备方法及其用于制备用于治疗或预防病症,特别是过度增殖性疾病的药物的用途。
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2.Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders 失效
标题翻译: 用于治疗高增殖性疾病的取代的四氢苯并噻吩并嘧啶胺化合物公开(公告)号:US20060293322A1
公开(公告)日:2006-12-28
申请号:US10557090
申请日:2004-07-23
申请人: Chengzhi Zhang , Gaetan Ladouceur , Catherine Brennan , Brent Chandler , Julie Dizon , Karl Miranda , Dongping Fan , Qingming Zhu , Sharad Verma , Jacques Dumas
发明人: Chengzhi Zhang , Gaetan Ladouceur , Catherine Brennan , Brent Chandler , Julie Dizon , Karl Miranda , Dongping Fan , Qingming Zhu , Sharad Verma , Jacques Dumas
IPC分类号: A61K31/5377 , A61K31/519 , C07D498/02
CPC分类号: C07D495/04 , C07D498/02
摘要: The present invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.
摘要翻译: 本发明涉及式(I)化合物及其在治疗高增殖性疾病中的用途。
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3.Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders 失效
标题翻译: 苯并呋喃和苯并噻吩衍生物可用于治疗高增殖性疾病公开(公告)号:US07351735B2
公开(公告)日:2008-04-01
申请号:US10501689
申请日:2003-02-21
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
IPC分类号: A61K31/343 , A61K31/381 , C07D307/80 , C07D333/56
CPC分类号: C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要: This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders
摘要翻译: 本发明涉及一般表配方的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途
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4.Fused tricyclic heterocycles useful for treating hyper-proliferative disorders 失效
标题翻译: 用于治疗高增殖性疾病的融合的三环杂环公开(公告)号:US07384947B2
公开(公告)日:2008-06-10
申请号:US11512032
申请日:2006-08-28
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott M. Wilhelm , Qian Zhao
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott M. Wilhelm , Qian Zhao
IPC分类号: A61K31/497 , A61K31/4355 , A61K31/4436 , A61K31/443 , A61K31/427
CPC分类号: C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要: This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及下式的新型稠合三环杂环及其用于治疗高增殖性疾病的用途。
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5.Fused tricyclic heterocycles useful for treating hyper-proliferative disorders 失效
标题翻译: 用于治疗高增殖性疾病的融合的三环杂环公开(公告)号:US20060287387A1
公开(公告)日:2006-12-21
申请号:US11512032
申请日:2006-08-28
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilhelm , Qian Zhao
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilhelm , Qian Zhao
IPC分类号: A61K31/381 , A61K31/343
CPC分类号: C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要: This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及下式的新型稠合三环杂环及其用于治疗高增殖性疾病的用途。
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6.Fused tricyclic heterocycles useful for treating hyper-proliferative disoroders 失效
标题翻译: 用于治疗超增殖解调器的融合的三环杂环公开(公告)号:US20050165042A1
公开(公告)日:2005-07-28
申请号:US10501690
申请日:2003-02-21
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilheim , Qian Zhao
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilheim , Qian Zhao
IPC分类号: A61K31/343 , A61K31/381 , A61K31/4741 , A61K31/4743 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D407/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
CPC分类号: C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要: This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及式(Ia,Ib)的新型稠合三环杂环及其用于治疗高增殖性疾病的用途。
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7.Fused tricyclic heterocycles useful for treating hyper-proliferative disorders 失效
标题翻译: 用于治疗高增殖性疾病的融合的三环杂环公开(公告)号:US07144885B2
公开(公告)日:2006-12-05
申请号:US10501690
申请日:2003-02-21
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott M. Wilhelm , Qian Zhao
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott M. Wilhelm , Qian Zhao
IPC分类号: A61K31/497 , A61K31/4355 , A61K31/4436 , A61K31/443 , A61K31/427
CPC分类号: C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要: This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders
摘要翻译: 本发明涉及式(Ia,Ib)的新型稠合三环杂环及其用于治疗高增殖性疾病的用途
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8.Benzofuran and benzothiophene derivatives useful in the treatmint of hyper-proliferative disorders 失效
标题翻译: 苯并呋喃和苯并噻吩衍生物可用于高增殖性疾病的治疗公开(公告)号:US20050139814A1
公开(公告)日:2005-06-30
申请号:US10501689
申请日:2003-02-21
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Philiips
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Philiips
IPC分类号: A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/422 , A61K31/427 , A61K31/4355 , A61K31/443 , A61K31/4436 , A61K31/455 , A61K31/497 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P35/04 , B66F3/36 , C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D491/048 , C07D493/04
CPC分类号: C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要: This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及通用表配方的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途。
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9.Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders 失效
标题翻译: 苯并呋喃和苯并噻吩衍生物可用于治疗高增殖性疾病公开(公告)号:US07585888B2
公开(公告)日:2009-09-08
申请号:US12059984
申请日:2008-03-31
申请人: Chengzhi Zhang , Michael J. Burke , Zhi Chen , Jacques P. Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
发明人: Chengzhi Zhang , Michael J. Burke , Zhi Chen , Jacques P. Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
IPC分类号: A61K31/343 , A61K31/381
CPC分类号: C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要: This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及通式的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途。
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10.
公开(公告)号:US08501755B2
公开(公告)日:2013-08-06
申请号:US12225285
申请日:2007-03-20
申请人: Chengzhi Zhang , Kanwar Sidhu , Mario Lobell , Gaetan Ladouceur , Qian Zhao , Zheng Liu , Kristen M. Allegue , Chetan P. Darne , Jason Newcom
发明人: Chengzhi Zhang , Kanwar Sidhu , Mario Lobell , Gaetan Ladouceur , Qian Zhao , Zheng Liu , Kristen M. Allegue , Chetan P. Darne , Jason Newcom
IPC分类号: A61K31/519 , C07D471/14
CPC分类号: C07D495/14
摘要: This invention relates to compounds of Formula (I), wherein the variables are as disclosed in the specification, to pharmaceutical compositions containing them, to methods of making the compounds and pharmaceutical compositions, and to methods of using the compounds and pharmaceutical compositions for treating or preventing disorders, in particular cancer.
摘要翻译: 本发明涉及式(I)化合物,其中变量如本说明书中所公开的,含有它们的药物组合物,制备化合物和药物组合物的方法,以及使用该化合物和药物组合物治疗或 预防疾病,特别是癌症。
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