-
1.Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders 失效
标题翻译: 苯并呋喃和苯并噻吩衍生物可用于治疗高增殖性疾病公开(公告)号:US07585888B2
公开(公告)日:2009-09-08
申请号:US12059984
申请日:2008-03-31
申请人: Chengzhi Zhang , Michael J. Burke , Zhi Chen , Jacques P. Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
发明人: Chengzhi Zhang , Michael J. Burke , Zhi Chen , Jacques P. Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
IPC分类号: A61K31/343 , A61K31/381
CPC分类号: C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要: This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及通式的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途。
-
2.Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders 失效
标题翻译: 苯并呋喃和苯并噻吩衍生物可用于治疗高增殖性疾病公开(公告)号:US07351735B2
公开(公告)日:2008-04-01
申请号:US10501689
申请日:2003-02-21
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips
IPC分类号: A61K31/343 , A61K31/381 , C07D307/80 , C07D333/56
CPC分类号: C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要: This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders
摘要翻译: 本发明涉及一般表配方的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途
-
3.Benzofuran and benzothiophene derivatives useful in the treatmint of hyper-proliferative disorders 失效
标题翻译: 苯并呋喃和苯并噻吩衍生物可用于高增殖性疾病的治疗公开(公告)号:US20050139814A1
公开(公告)日:2005-06-30
申请号:US10501689
申请日:2003-02-21
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Philiips
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Philiips
IPC分类号: A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/422 , A61K31/427 , A61K31/4355 , A61K31/443 , A61K31/4436 , A61K31/455 , A61K31/497 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P35/04 , B66F3/36 , C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D491/048 , C07D493/04
CPC分类号: C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要: This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及通用表配方的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途。
-
4.Fused tricyclic heterocycles useful for treating hyper-proliferative disorders 失效
标题翻译: 用于治疗高增殖性疾病的融合的三环杂环公开(公告)号:US07384947B2
公开(公告)日:2008-06-10
申请号:US11512032
申请日:2006-08-28
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott M. Wilhelm , Qian Zhao
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott M. Wilhelm , Qian Zhao
IPC分类号: A61K31/497 , A61K31/4355 , A61K31/4436 , A61K31/443 , A61K31/427
CPC分类号: C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要: This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及下式的新型稠合三环杂环及其用于治疗高增殖性疾病的用途。
-
5.Fused tricyclic heterocycles useful for treating hyper-proliferative disorders 失效
标题翻译: 用于治疗高增殖性疾病的融合的三环杂环公开(公告)号:US07144885B2
公开(公告)日:2006-12-05
申请号:US10501690
申请日:2003-02-21
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott M. Wilhelm , Qian Zhao
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott M. Wilhelm , Qian Zhao
IPC分类号: A61K31/497 , A61K31/4355 , A61K31/4436 , A61K31/443 , A61K31/427
CPC分类号: C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要: This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders
摘要翻译: 本发明涉及式(Ia,Ib)的新型稠合三环杂环及其用于治疗高增殖性疾病的用途
-
6.Fused tricyclic heterocycles useful for treating hyper-proliferative disorders 失效
标题翻译: 用于治疗高增殖性疾病的融合的三环杂环公开(公告)号:US20060287387A1
公开(公告)日:2006-12-21
申请号:US11512032
申请日:2006-08-28
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilhelm , Qian Zhao
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilhelm , Qian Zhao
IPC分类号: A61K31/381 , A61K31/343
CPC分类号: C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要: This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及下式的新型稠合三环杂环及其用于治疗高增殖性疾病的用途。
-
7.Fused tricyclic heterocycles useful for treating hyper-proliferative disoroders 失效
标题翻译: 用于治疗超增殖解调器的融合的三环杂环公开(公告)号:US20050165042A1
公开(公告)日:2005-07-28
申请号:US10501690
申请日:2003-02-21
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilheim , Qian Zhao
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilheim , Qian Zhao
IPC分类号: A61K31/343 , A61K31/381 , A61K31/4741 , A61K31/4743 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D407/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
CPC分类号: C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要: This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及式(Ia,Ib)的新型稠合三环杂环及其用于治疗高增殖性疾病的用途。
-
8.
公开(公告)号:US20080214545A1
公开(公告)日:2008-09-04
申请号:US11579093
申请日:2005-05-02
申请人: Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
发明人: Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
IPC分类号: A61K31/5377 , C07D401/12 , C07D413/14 , A61P35/02 , A61P35/00 , A61K31/4439
CPC分类号: C07D401/12 , C07D405/14
摘要: The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
摘要翻译: 本发明涉及式(I)化合物,含有它们的药物组合物和使用式(I)化合物治疗癌症的方法。
-
9.
公开(公告)号:US07838524B2
公开(公告)日:2010-11-23
申请号:US11579093
申请日:2005-05-02
申请人: Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
发明人: Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
IPC分类号: A61K31/4439 , A61K31/5377 , A61K31/497 , A61K31/454 , C07D401/14 , C07D413/14
CPC分类号: C07D401/12 , C07D405/14
摘要: The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
摘要翻译: 本发明涉及式(I)化合物,含有它们的药物组合物和使用式(I)化合物治疗癌症的方法。
-
10.2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 审中-公开
标题翻译: 用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号:US20050215594A1
公开(公告)日:2005-09-29
申请号:US11117759
申请日:2005-04-28
申请人: Stephen O'Connor , Gaetan Ladouceur , William Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek Lowe , Steven Magnuson , Ning Qi , Tatiana Skelekhin , Quanrong Shen , Roger Smith , Ming Wang
发明人: Stephen O'Connor , Gaetan Ladouceur , William Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek Lowe , Steven Magnuson , Ning Qi , Tatiana Skelekhin , Quanrong Shen , Roger Smith , Ming Wang
IPC分类号: A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D45/02
CPC分类号: C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译: 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
-
-
-
-
-
-
-
-
-