公开(公告)号：US07285550B2

公开(公告)日：2007-10-23

申请号：US10552303

申请日：2004-04-09

申请人： Chi Vu ,  Russell C. Petter ,  Gnanasambandam Kumaravel

发明人： Chi Vu ,  Russell C. Petter ,  Gnanasambandam Kumaravel

IPC分类号： C07D487/04 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  A61K31/53 ,  A61P25/16

CPC分类号： C07D487/04

摘要： The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula I: (I)

摘要翻译： 本发明基于以下发现：式（I）化合物对Aβ2α腺苷受体具有意想不到的高亲和力，并且可用作其用于预防和/或治疗多种疾病的拮抗剂，包括帕金森病 疾病。 在一个实施方案中，本发明的特征在于式I的化合物：（I）

公开(公告)号：US20070010522A1

公开(公告)日：2007-01-11

申请号：US10552302

申请日：2004-04-09

申请人： Chi Vu ,  Russell Petter ,  Gnanasambandam Kumaravel

发明人： Chi Vu ,  Russell Petter ,  Gnanasambandam Kumaravel

IPC分类号： A61K31/519 ,  C07D487/04

CPC分类号： C07D487/04

摘要： The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula (I).

摘要翻译： 本发明基于以下发现：式（I）化合物对A2a腺苷受体具有意想不到的高亲和力，并且可用作其拮抗剂，用于预防和/或治疗包括帕金森病在内的许多疾病。 在一个实施方案中，本发明的特征在于式（I）的化合物。

公开(公告)号：US20080070932A1

公开(公告)日：2008-03-20

申请号：US10552306

申请日：2004-04-09

申请人： Chi Vu ,  Russell C. Petter ,  Kumaravel Gnanasambandam

发明人： Chi Vu ,  Russell C. Petter ,  Kumaravel Gnanasambandam

IPC分类号： A61K31/519 ,  A61P43/00 ,  C07D487/02 ,  C12N5/00

CPC分类号： C07D487/04

摘要： The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagofiists. thereof for preventing and/or treating numerous diseases, including C) Parkinson's disease. In one embodiment, the invention features a compound of formual (I).

摘要翻译： 本发明基于以下发现：式（I）化合物对A2a腺苷受体具有出人意料的高亲和力，并且可用作抗角膜炎药。 用于预防和/或治疗许多疾病，包括C）帕金森病。 在一个实施方案中，本发明的特征在于式（I）化合物。

公开(公告)号：US20070037827A1

公开(公告)日：2007-02-15

申请号：US11499239

申请日：2006-08-04

申请人： Joseph Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi Vu ,  Pui Ng ,  Jeremy Disch

发明人： Joseph Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi Vu ,  Pui Ng ,  Jeremy Disch

IPC分类号： A61K31/496 ,  A61K31/4745 ,  C07D471/02

CPC分类号： C07D471/04

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，凝血障碍，炎症，癌症和/或潮红以及由线粒体活性增加所致的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

公开(公告)号：US20090319023A1

公开(公告)日：2009-12-24

申请号：US12397123

申请日：2009-03-03

申请人： Daniel K. Hildebrand ,  Nicholas C. deBeer ,  Maria G. Aboytes ,  Arturo S. Rosqueta ,  Chi Vu ,  Siddharth Loganathan ,  Frank P. Becking

发明人： Daniel K. Hildebrand ,  Nicholas C. deBeer ,  Maria G. Aboytes ,  Arturo S. Rosqueta ,  Chi Vu ,  Siddharth Loganathan ,  Frank P. Becking

IPC分类号： A61F2/06

CPC分类号： A61F2/915 ,  A61F2/07 ,  A61F2/90 ,  A61F2002/075 ,  A61F2220/0033 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054

摘要： The subjected devices include a stent, a graft and a means for attaching the graft to the stent. One or more members are received in a permanent or temporary receptacle within the stent attach the graft to the stent. In one variation, an interference fit is employed; in another, the graft is bonded to a stent-captured member(s).

摘要翻译： 受影响的装置包括支架，移植物和用于将移植物附接到支架的装置。 将一个或多个构件容纳在支架内的永久性或临时容器中，将移植物附接到支架上。 在一个变型中，采用过盈配合; 另一方面，移植物被结合到支架捕获的构件上。

公开(公告)号：US06605601B2

公开(公告)日：2003-08-12

申请号：US09997740

申请日：2001-11-30

申请人： Ko-Chung Lin ,  Chi Vu

发明人： Ko-Chung Lin ,  Chi Vu

IPC分类号： C07D49714

CPC分类号： A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  C07D487/14

摘要： Compounds of Formula I and II are disclosed as antagonists of subtype A1 adenosine receptors. These compounds are useful for treatment of various diseases and disorders, including systemic hypertension, renal failure, diabetes, asthma, an edematous condition, congestive heart failure, and renal dysfunction.

公开(公告)号：US20070037865A1

公开(公告)日：2007-02-15

申请号：US11499920

申请日：2006-08-04

申请人： Joseph Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi Vu ,  Pui Ng ,  Jeremy Disch

发明人： Joseph Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi Vu ,  Pui Ng ,  Jeremy Disch

IPC分类号： A61K31/42 ,  A61K31/4184 ,  C07D413/02 ,  C07D403/02

CPC分类号： C07D235/18 ,  C07D401/12 ,  C07D403/12 ,  C07D513/04

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

公开(公告)号：US20070037810A1

公开(公告)日：2007-02-15

申请号：US11499901

申请日：2006-08-04

申请人： Joseph Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi Vu ,  Pui Ng ,  Jeremy Disch ,  Thomas Salzmann ,  David Armistead

发明人： Joseph Nunes ,  Jill Milne ,  Jean Bemis ,  Roger Xie ,  Chi Vu ,  Pui Ng ,  Jeremy Disch ,  Thomas Salzmann ,  David Armistead

IPC分类号： A61K31/53 ,  A61K31/501 ,  A61K31/497 ,  A61K31/506 ,  A61K31/4745 ,  C07D491/02

CPC分类号： C07D209/80 ,  C07C233/81 ,  C07C235/56 ,  C07C237/42 ,  C07D207/327 ,  C07D215/12 ,  C07D235/18 ,  C07D241/42 ,  C07D243/08 ,  C07D249/08 ,  C07D263/57 ,  C07D265/14 ,  C07D271/107 ,  C07D277/26 ,  C07D277/28 ,  C07D277/66 ,  C07D295/155 ,  C07D307/68 ,  C07D333/38 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D513/04

摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

公开(公告)号：US07022686B2

公开(公告)日：2006-04-04

申请号：US10446573

申请日：2003-05-27

申请人： Ko-Chung Lin ,  Chi Vu

发明人： Ko-Chung Lin ,  Chi Vu

IPC分类号： C07D487/14 ,  A61K31/519 ,  A61P31/10 ,  A61P11/06 ,  A61P13/12

CPC分类号： A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  C07D487/14

摘要： Compounds of Formula I and II are disclosed as antagonists of subtype A1 adenosine receptors. These compounds are useful for treatment of various diseases and disorders, including systemic hypertension, renal failure, diabetes, asthma, an edematous condition, congestive heart failure, and renal dysfunction.

公开(公告)号：US20120330341A1

公开(公告)日：2012-12-27

申请号：US13166136

申请日：2011-06-22

申请人： Frank P. Becking ,  Siddharth Loganathan ,  Chi Vu ,  Karl S. Halden ,  Arturo S. Rosqueta

发明人： Frank P. Becking ,  Siddharth Loganathan ,  Chi Vu ,  Karl S. Halden ,  Arturo S. Rosqueta

IPC分类号： A61M29/00 ,  B23P11/00

CPC分类号： A61B17/12172 ,  A61B17/12145 ,  A61B17/12154 ,  A61B17/12177 ,  A61B2017/00526 ,  Y10T29/49826

摘要： Embolic implants, methods of manufacture and delivery are disclosed. The subject implants are especially suitable for use is stent-caged aneurysm treatment.

摘要翻译： 公开了栓塞植入物，制造和递送方法。 受试植入物特别适用于支架置入的动脉瘤治疗。