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公开(公告)号：US08580312B2
公开(公告)日：2013-11-12
申请号：US13578836
申请日：2011-02-17
申请人： Chiaki Ogino , Tsutomu Tanaka , Ryohei Sasaki , Akihiko Kondo
发明人： Chiaki Ogino , Tsutomu Tanaka , Ryohei Sasaki , Akihiko Kondo
IPC分类号： A61P35/00 , A61K9/14 , A61K39/395 , C07K16/18 , C07K16/00
CPC分类号： A61K9/0019 , A61K33/40 , A61K41/0057 , A61K47/6835 , A61K2039/505 , A61N5/10 , A61N2005/1098 , C07K16/2863 , Y10T428/2982
摘要： Provided is a radiotherapeutic agent, including a composite particle, which is obtained by binding a molecule that specifically recognizes a target to a substrate particle including titanium peroxide, and which generates reactive oxygen through irradiation with a radiation. Further, because the radiotherapeutic agent contains the molecule that specifically recognizes a target, the radiotherapeutic agent has a function of accumulating in the target. The radiotherapeutic agent is capable of enhancing effects of radiotherapy, and is capable of reducing side effects on a living body to efficiently attack the target.
摘要翻译： 本发明提供一种放射治疗剂，包括复合颗粒，其通过将特异性识别靶标的分子与包含过氧化钛的底物颗粒结合而获得，并且通过辐射照射产生活性氧。 此外，由于放射治疗剂含有特异性识别靶标的分子，所以放射治疗剂具有累积在靶内的功能。 放射治疗剂能够增强放射疗法的作用，并且能够减少对活体的副作用以有效地攻击靶。
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公开(公告)号：US20130017266A1
公开(公告)日：2013-01-17
申请号：US13578836
申请日：2011-02-17
申请人： Chiaki Ogino , Tsutomu Tanaka , Ryohei Sasaki , Akihiko Kondo
发明人： Chiaki Ogino , Tsutomu Tanaka , Ryohei Sasaki , Akihiko Kondo
CPC分类号： A61K9/0019 , A61K33/40 , A61K41/0057 , A61K47/6835 , A61K2039/505 , A61N5/10 , A61N2005/1098 , C07K16/2863 , Y10T428/2982
摘要： Provided is a radiotherapeutic agent, including a composite particle, which is obtained by binding a molecule that specifically recognizes a target to a substrate particle including titanium peroxide, and which generates reactive oxygen through irradiation with a radiation. Further, because the radiotherapeutic agent contains the molecule that specifically recognizes a target, the radiotherapeutic agent has a function of accumulating in the target. The radiotherapeutic agent is capable of enhancing effects of radiotherapy, and is capable of reducing side effects on a living body to efficiently attack the target.
摘要翻译： 本发明提供一种放射治疗剂，包括复合颗粒，其通过将特异性识别靶标的分子与包含过氧化钛的底物颗粒结合而获得，并且通过辐射照射产生活性氧。 此外，由于放射治疗剂含有特异性识别靶标的分子，所以放射治疗剂具有累积在靶内的功能。 放射治疗剂能够增强放射疗法的作用，并且能够减少对活体的副作用以有效地攻击靶。
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3.发明申请公开(公告)号：US20110033906A1
公开(公告)日：2011-02-10
申请号：US12850966
申请日：2010-08-05
申请人： Sung-Jin JO , Risa Nakamura , Satoshi Katahira , Nobuhiro Ishida , Haruo Takahashi , Kazuhide Tabata , Kazunori Nakashima , Chiaki Ogino , Akihiko Kondo , Naoko Takahashi
发明人： Sung-Jin JO , Risa Nakamura , Satoshi Katahira , Nobuhiro Ishida , Haruo Takahashi , Kazuhide Tabata , Kazunori Nakashima , Chiaki Ogino , Akihiko Kondo , Naoko Takahashi
IPC分类号： C12P7/06
CPC分类号： C12P7/10 , C12P2201/00 , Y02E50/16 , Y02E50/17
摘要： The present invention provides a method for producing a useful substance efficiently from cellulose without using any cellulase preparation. According to the disclosures of the present specification, in the production of a useful substance from a cellulose-containing material, the cellulose-containing material is brought into contact with an ionic liquid to cause the ionic liquid to permeate the cellulose-containing material, and a carbon source comprising the cellulose in the cellulose-containing material is simultaneously saccharified and fermented by a cellulase-producing microorganism in the presence of the ionic liquid.
摘要翻译： 本发明提供一种在不使用任何纤维素酶制剂的情况下有效地从纤维素制备有用物质的方法。 根据本说明书的公开内容，在从含纤维素材料制造有用物质时，使含纤维素材料与离子液体接触，使离子液体渗透含纤维素材料， 含有纤维素的材料中的纤维素的碳源同时在离子液体存在下被纤维素酶微生物糖化并发酵。
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4.发明授权公开(公告)号：US09587254B2
公开(公告)日：2017-03-07
申请号：US12850966
申请日：2010-08-05
申请人： Sung-Jin Jo , Risa Nakamura , Satoshi Katahira , Nobuhiro Ishida , Haruo Takahashi , Naoko Takahashi , Kazuhide Tabata , Kazunori Nakashima , Chiaki Ogino , Akihiko Kondo
发明人： Sung-Jin Jo , Risa Nakamura , Satoshi Katahira , Nobuhiro Ishida , Haruo Takahashi , Kazuhide Tabata , Kazunori Nakashima , Chiaki Ogino , Akihiko Kondo
IPC分类号： C12P7/10
CPC分类号： C12P7/10 , C12P2201/00 , Y02E50/16 , Y02E50/17
摘要： The present invention provides a method for producing a useful substance efficiently from cellulose without using any cellulase preparation. According to the disclosures of the present specification, in the production of a useful substance from a cellulose-containing material, the cellulose-containing material is brought into contact with an ionic liquid to cause the ionic liquid to permeate the cellulose-containing material, and a carbon source comprising the cellulose in the cellulose-containing material is simultaneously saccharified and fermented by a cellulase-producing microorganism in the presence of the ionic liquid.
摘要翻译： 本发明提供一种在不使用任何纤维素酶制剂的情况下有效地从纤维素制备有用物质的方法。 根据本说明书的公开内容，在从含纤维素材料制造有用物质时，使含纤维素材料与离子液体接触，使离子液体渗透含纤维素材料， 含有纤维素的材料中的纤维素的碳源同时在离子液体存在下被纤维素酶微生物糖化并发酵。
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公开(公告)号：US08252577B2
公开(公告)日：2012-08-28
申请号：US12431102
申请日：2009-04-28
申请人： Akihiko Kondo , Hideki Fukuda , Tsutomu Tanaka , Hideo Noda
发明人： Akihiko Kondo , Hideki Fukuda , Tsutomu Tanaka , Hideo Noda
IPC分类号： C12N1/20 , C12N1/00 , C12N9/10 , C12Q1/00 , C12Q1/48 , G01N33/567 , G01N33/53 , C12P21/06 , C12P21/04
CPC分类号： C12N15/1037 , C12N9/93
摘要： Provided is a microorganism that can display, on the cell surface, any molecules other than a molecule comprising amino acids, more specifically, a microorganism that displays biotin on a cell surface. The microorganism is capable of co-expressing a biotinylating enzyme and an acceptor peptide having a sequence recognized by the biotinylating enzyme, wherein the acceptor peptide is expressed on the cell surface, so that lysine of the acceptor peptide is biotinylated to display biotin on the cell surface. Also provided is a method for displaying an intended molecule, including not only a molecule comprising amino acids but also any molecules, on a cell surface of a microorganism.
摘要翻译： 本发明提供能够在细胞表面上显示除氨基酸分子以外的任何分子，更具体地，在细胞表面上显示生物素的微生物的微生物。 微生物能够共表达生物素化酶和具有生物素化酶识别的序列的受体肽，其中受体肽在细胞表面上表达，使得受体肽的赖氨酸被生物素化以在细胞上显示生物素 表面。 还提供了在微生物的细胞表面上显示预期分子的方法，不仅包括包含氨基酸的分子，而且包括任何分子。
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公开(公告)号：US20090275110A1
公开(公告)日：2009-11-05
申请号：US12431102
申请日：2009-04-28
申请人： Akihiko Kondo , Hideki Fukuda , Tsutomu Tanaka , Hideo Noda
发明人： Akihiko Kondo , Hideki Fukuda , Tsutomu Tanaka , Hideo Noda
CPC分类号： C12N15/1037 , C12N9/93
摘要： Provided is a microorganism that can display, on the cell surface, any molecules other than a molecule comprising amino acids, more specifically, a microorganism that displays biotin on a cell surface. The microorganism is capable of co-expressing a biotinylating enzyme and an acceptor peptide having a sequence recognized by the biotinylating enzyme, wherein the acceptor peptide is expressed on the cell surface, so that lysine of the acceptor peptide is biotinylated to display biotin on the cell surface. Also provided is a method for displaying an intended molecule, including not only a molecule comprising amino acids but also any molecules, on a cell surface of a microorganism.
摘要翻译： 本发明提供能够在细胞表面上显示除氨基酸分子以外的任何分子，更具体地，在细胞表面上显示生物素的微生物的微生物。 微生物能够共表达生物素化酶和具有由生物素化酶识别的序列的受体肽，其中受体肽在细胞表面上表达，使得受体肽的赖氨酸被生物素化以在细胞上显示生物素 表面。 还提供了在微生物的细胞表面上显示预期分子的方法，不仅包括包含氨基酸的分子，而且包括任何分子。
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公开(公告)号：US20120282666A1
公开(公告)日：2012-11-08
申请号：US13512895
申请日：2010-06-30
申请人： Hideo Noda , Shohei Kaneko , Akihiko Kondo
发明人： Hideo Noda , Shohei Kaneko , Akihiko Kondo
摘要： The present invention provides a method for producing ethanol, including: subjecting a cellulose-based material to a hot-water treatment and an ammonia treatment to obtain a fermentation substrate; and reacting the fermentation substrate with a yeast to produce ethanol. The present invention also provides a method for producing a fermentation substrate for ethanol production by a yeast, including: subjecting a cellulose material to a hot-water treatment and an ammonia treatment to obtain a fermentation substrate. Thus obtained fermentation substrate can enhance the ethanol production by yeast.
摘要翻译： 本发明提供一种生产乙醇的方法，包括：对纤维素基材料进行热水处理和氨处理以获得发酵基材; 并使发酵底物与酵母反应以产生乙醇。 本发明还提供一种由酵母生产乙醇生产发酵底物的方法，包括：对纤维素材料进行热水处理和氨处理以获得发酵基质。 这样得到的发酵底物可以提高酵母的乙醇产量。
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公开(公告)号：US07192764B2
公开(公告)日：2007-03-20
申请号：US10474431
申请日：2002-03-22
申请人： Hideki Fukuda , Akihiko Kondo , Takeshi Matsumoto , Hideo Noda
发明人： Hideki Fukuda , Akihiko Kondo , Takeshi Matsumoto , Hideo Noda
CPC分类号： C40B40/02 , C07K14/395 , C07K2319/00 , C07K2319/02 , C12N11/16 , C12N15/1037
摘要： A plasmid is constructed so as to express a fused protein of a sugar chain-binding protein domain with a desired protein. Then this plasmid is transferred into cells and thus the protein is expressed in the cell surface layer. This method is particularly adequate in case of expressing a protein having an activity in the C-terminal portion in cell surface layer.
摘要翻译： 构建质粒以便表达具有所需蛋白质的糖链结合蛋白结构域的融合蛋白。 然后将该质粒转移到细胞中，因此蛋白质在细胞表面层中表达。 在表达在细胞表面层的C末端部分具有活性的蛋白质的情况下，该方法特别合适。
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9.发明申请Hollow nanoparticle having modified cysteine residue and drug with the use thereof 审中-公开具有修饰的半胱氨酸残基的中空纳米颗粒和其使用的药物公开(公告)号：US20060141042A1
公开(公告)日：2006-06-29
申请号：US10519559
申请日：2003-06-27
申请人： Shunichi Kuroda , Katsuyuki Tanizawa , Akihiko Kondo , Masakazu Ueda , Masaharu Seno , Hiroko Tada
发明人： Shunichi Kuroda , Katsuyuki Tanizawa , Akihiko Kondo , Masakazu Ueda , Masaharu Seno , Hiroko Tada
CPC分类号： A61K9/5169 , A61K38/00 , A61K48/00 , A61K48/0025 , C07K14/005 , C12N15/88 , C12N2730/10122
摘要： The invention provides hollow nanoparticles of a protein with the ability to recognize specific cells such as the hepatocytes and to form particles (for example, hepatitis B virus surface-antigen protein), wherein the protein has a cysteine residue substituted to a different amino acid. The hollow nanoparticles have a stable particle structure and can be used to efficiently transfer substances to specific target cells or tissues. The invention also provides a drug using the hollow nanoparticles.
摘要翻译： 本发明提供具有识别特定细胞如肝细胞并形成颗粒（例如，乙型肝炎病毒表面抗原蛋白）的能力的蛋白质的中空纳米颗粒，其中所述蛋白质具有被不同氨基酸取代的半胱氨酸残基。 中空纳米颗粒具有稳定的颗粒结构，可用于有效地将物质转移到特定的靶细胞或组织。 本发明还提供了使用中空纳米颗粒的药物。
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公开(公告)号：US08715972B2
公开(公告)日：2014-05-06
申请号：US13202218
申请日：2010-02-15
申请人： Akihiko Kondo , Kenji Okano , Hideo Noda
发明人： Akihiko Kondo , Kenji Okano , Hideo Noda
摘要： Provided is a lactic acid bacterium capable of homolactic fermentation using a pentose as a substrate, the lactic acid bacterium utilizing a pentose, and in which a phosphoketolase pathway is blocked and a pentose phosphate pathway is activated. Also provided is a method for producing lactic acid from a pentose using the lactic acid bacterium and a method for preparing the lactic acid bacterium.
摘要翻译： 本发明提供能够使用戊糖作为基质进行均相发酵的乳酸菌，利用戊糖的乳酸菌，磷酸酮糖苷酶途径被阻断，磷酸戊糖途径被活化。 还提供了使用乳酸菌从戊糖生产乳酸的方法和制备乳酸菌的方法。
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