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1.Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor 有权
标题翻译: 融合的氮杂双环化合物抑制香草素受体亚型1(VR1)受体公开(公告)号:US08247413B2
公开(公告)日:2012-08-21
申请号:US12033233
申请日:2008-02-19
申请人: Chih-Hung Lee , Erol K. Bayburt , Stanley Didomenico, Jr. , Irene Drizin , Arthur R. Gomtsyan , John R. Koenig , Richard J. Perner , Robert G. Schmidt, Jr. , Sean C. Turner , Tammie K. White , Guo Zhu Zheng
发明人: Chih-Hung Lee , Erol K. Bayburt , Stanley Didomenico, Jr. , Irene Drizin , Arthur R. Gomtsyan , John R. Koenig , Richard J. Perner , Robert G. Schmidt, Jr. , Sean C. Turner , Tammie K. White , Guo Zhu Zheng
IPC分类号: A61K31/50 , A01N43/58 , C07D237/26 , C07D487/00 , C07D237/28
CPC分类号: C07D249/08 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
摘要: Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X1, X2, X3, X4, X5, R5, R6, R7, R8a, R8b, R9, Z1, Z2 and L are as defined in the description.
摘要翻译: 式(I)化合物是可用于治疗疼痛,炎性热痛觉过敏,尿失禁和膀胱过度活动的新型VR1拮抗剂,其中X1,X2,X3,X4,X5,R5,R6,R7,R8a,R8b,R9, Z1,Z2和L如说明书中所定义。