-
公开(公告)号:US20080255203A1
公开(公告)日:2008-10-16
申请号:US11953590
申请日:2007-12-10
申请人: Chih-Hung Lee , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , Murali Gopalakrishnan
发明人: Chih-Hung Lee , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , Murali Gopalakrishnan
IPC分类号: A61K31/4439 , C07D413/00 , A61P25/00 , A61P31/12
CPC分类号: C07D413/14
摘要: The invention relates to heterocyclic derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions. The heterocyclic derivatives, more particularly can be substituted oxadiazole compounds and derivatives thereof.
摘要翻译: 本发明涉及杂环衍生物,包含这些化合物的组合物,以及使用这些化合物和组合物预防或治疗病症和障碍的方法。 杂环衍生物,更特别地可以是取代的恶二唑化合物及其衍生物。
-
公开(公告)号:US20080167286A1
公开(公告)日:2008-07-10
申请号:US11953625
申请日:2007-12-10
申请人: Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
发明人: Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
IPC分类号: A61K31/397 , A61K31/4439 , C07D413/04 , A61P25/00
CPC分类号: A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
摘要: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
摘要翻译: 本发明涉及包含神经元烟碱性受体配体和α4β2阳性变构调节剂的组合物,其使用方法和相关制造方法。
-
公开(公告)号:US20110190314A1
公开(公告)日:2011-08-04
申请号:US13080071
申请日:2011-04-05
申请人: Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
发明人: Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
IPC分类号: A61K31/4439 , C07D413/04 , C07D413/14 , A61K31/444 , A61K31/497 , A61K31/496 , A61P25/00 , A61P25/28 , A61P25/32 , A61P25/30 , A61P25/18 , A61P9/10 , A61P29/00 , A61P31/00
CPC分类号: A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
摘要: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
摘要翻译: 本发明涉及包含神经元烟碱性受体配体和α4和bgr2阳性变构调节剂,其使用方法和相关制品的组合物。
-
公开(公告)号:US09186407B2
公开(公告)日:2015-11-17
申请号:US13080071
申请日:2011-04-05
申请人: Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
发明人: Murali Gopalakrishnan , Marie P. Honore , Chih-Hung Lee , John Malysz , Jianguo Ji , Tao Li , Michael R. Schrimpf , Kevin B. Sippy , David J. Anderson
IPC分类号: A01N43/82 , A61K31/41 , A01N43/40 , A61K31/44 , C07D413/00 , C07D413/04 , C07D413/14 , A61K31/4245 , A61K31/443 , A61K31/444 , A61K45/06
CPC分类号: A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
摘要: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
摘要翻译: 本发明涉及包含神经元烟碱性受体配体和α4和bgr2阳性变构调节剂,其使用方法和相关制品的组合物。
-
公开(公告)号:US09625475B2
公开(公告)日:2017-04-18
申请号:US12727723
申请日:2010-03-19
申请人: Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人: Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号: A61K31/55 , C07D487/00 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00 , G01N33/68 , C07D471/18 , C07D487/10 , G01N33/50
CPC分类号: G01N33/6896 , C07D471/18 , C07D487/10 , G01N33/5058 , G01N2800/2814 , G01N2800/30
摘要: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
-
公开(公告)号:US20100249105A1
公开(公告)日:2010-09-30
申请号:US12727723
申请日:2010-03-19
申请人: Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人: Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号: A61K31/55 , A61P25/28 , A61P25/16 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/02 , C07D487/04 , A61K31/439 , C07D471/00
CPC分类号: G01N33/6896 , C07D471/18 , C07D487/10 , G01N33/5058 , G01N2800/2814 , G01N2800/30
摘要: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
-
公开(公告)号:US20100087471A1
公开(公告)日:2010-04-08
申请号:US12568085
申请日:2009-09-28
申请人: Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人: Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号: A61K31/439 , C12Q1/02 , C07D471/08
CPC分类号: G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
摘要: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译: 本申请涉及式(I),(II),(III),(IV),(V)或(VI)的吲哚和二氢吲哚衍生物,其中a,R1,R2,R3,R4,R5, V,W,X,Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物,以及使用这些化合物和组合物治疗疾病状况的方法,以及鉴定这些化合物的方法。
-
公开(公告)号:US09063126B2
公开(公告)日:2015-06-23
申请号:US12568085
申请日:2009-09-28
申请人: Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
发明人: Michael R. Schrimpf , Chih-Hung Lee , Tao Li , Gregory A. Gfesser , Kathleen H. Mortell , Ramin Faghih , Diana L. Nersesian , Kevin B. Sippy , William H. Bunnelle , Marc Scanio , Lei Shi , Murali Gopalakrishnan , Diana L. Donnelly-Roberts , Min Hu
IPC分类号: A61K31/439 , C07D471/08 , G01N33/50 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/68
CPC分类号: G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
摘要: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译: 本申请涉及式(I),(II),(III),(IV),(V)或(VI)的吲哚和二氢吲哚衍生物,其中a,R1,R2,R3,R4,R5, V,W,X,Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物,以及使用这些化合物和组合物治疗疾病状况的方法,以及鉴定这些化合物的方法。
-
公开(公告)号:US20100305086A1
公开(公告)日:2010-12-02
申请号:US12787937
申请日:2010-05-26
申请人: Murali Gopalakrishnan , Chih-Hung Lee , Jianguo Ji , Tao Li , Kevin B. Sippy
发明人: Murali Gopalakrishnan , Chih-Hung Lee , Jianguo Ji , Tao Li , Kevin B. Sippy
IPC分类号: A61K31/397 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61P19/02 , A61P29/00 , A61P9/10 , A61P35/00
CPC分类号: A61K45/06 , A61K31/4245 , A61K31/4427 , A61K2300/00
摘要: This invention discloses a method of treatment of osteoarthritis pain by administration of a composition containing a nicotinic acetylcholine receptor ligand and a nicotinic acetylcholine receptor subtype α4β2 allosteric modulator. The present application also relates to compositions comprising such compounds for use in treating pain and related disorders mediated by controlling neurotransmitter release in a subject.
摘要翻译: 本发明公开了一种通过施用含有烟碱乙酰胆碱受体配体和烟碱乙酰胆碱受体亚型α4和bgr2变构调节剂的组合物治疗骨关节炎疼痛的方法。 本申请还涉及包含用于治疗疼痛和通过控制受试者中的神经递质释放介导的相关病症的化合物的组合物。
-
公开(公告)号:US20120065219A1
公开(公告)日:2012-03-15
申请号:US13296895
申请日:2011-11-15
申请人: Jianguo Ji , Michael R. Schrimpf , Kevin B. Sippy , Tao Li , Chih-Hung Lee
发明人: Jianguo Ji , Michael R. Schrimpf , Kevin B. Sippy , Tao Li , Chih-Hung Lee
IPC分类号: A61K31/439 , A61P25/28 , A61P25/00 , A61P25/18 , A61P19/02 , A61P15/08 , A61P9/00 , A61P9/10 , A61P29/00 , C07D491/22 , A61P25/04
CPC分类号: C07D471/18
摘要: The invention relates to compounds that are spirocyclic azaadamantane derivatives, particularly spirocyclic azaadamantanyl ether or amine derivatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
摘要翻译: 本发明涉及作为螺环氮杂金刚烷衍生物,特别是螺环氮杂金刚烷基醚或胺衍生物的化合物,包含这些化合物的组合物,使用这些化合物和组合物的方法,制备这些化合物的方法以及在这些方法中获得的中间体。
-
-
-
-
-
-
-
-
-