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公开(公告)号：US07247645B2
公开(公告)日：2007-07-24
申请号：US10022874
申请日：2001-12-20
申请人： Chika Nakanishi , Yoko Masuzawa , Masako Hagihara , Takashi Yamamoto , Hiroyuki Matsueda , Seiji Ohno , Seiji Niwa , Morikazu Kito , Akira Takahara , Yukitsugu Ono , Tomoko Takeda , Yuki Kajigaya , Hajime Koganei
发明人： Chika Nakanishi , Yoko Masuzawa , Masako Hagihara , Takashi Yamamoto , Hiroyuki Matsueda , Seiji Ohno , Seiji Niwa , Morikazu Kito , Akira Takahara , Yukitsugu Ono , Tomoko Takeda , Yuki Kajigaya , Hajime Koganei
IPC分类号： A61K31/4436 , A61K31/4439 , A61K31/4545 , C07D401/04 , C07D407/06
CPC分类号： C07D211/90
摘要： Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.
摘要翻译： 提供具有选择性N型钙通道拮抗活性的化合物。 由下式表示的二氢吡啶衍生物：其类似物和其药学上可接受的盐具有选择性抑制N-型钙通道作用的活性，并且它们用作各种与N-型钙通道有关的疾病的治疗剂。
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公开(公告)号：US08278329B2
公开(公告)日：2012-10-02
申请号：US11924997
申请日：2007-10-26
申请人： Takashi Yamamoto , Seiji Niwa , Kayo Otani , Seiji Ohno , Hajime Koganei , Satoshi Iwayama , Akira Takahara , Yukitsugu Ono , Tomoko Takeda , Shinichi Fujita , Keiko Moki
发明人： Takashi Yamamoto , Seiji Niwa , Kayo Otani , Seiji Ohno , Hajime Koganei , Satoshi Iwayama , Akira Takahara , Yukitsugu Ono , Tomoko Takeda , Shinichi Fujita , Keiko Moki
IPC分类号： A61K31/445 , C07D211/18
CPC分类号： C07D295/205 , C07C237/06 , C07C271/20 , C07C271/22 , C07D211/70 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D417/06
摘要： The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH═CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C═C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.
摘要翻译： 本发明涉及由以下通式（1）表示的化合物或其类似物，其选择性地抑制N-型钙通道或其类似物，以及涉及治疗疼痛等的方法，其包含由以下通式表示的化合物 1）或其与需要这种治疗的患者的类似物：其中A表示CH = CH等，a，b，c和d表示CH等，R 1，R 2，R 3，R 4，R 5和R 6表示H 等等，V-W表示C = C等，n表示0〜3，Y 1表示O等，B表示 - （CH 2）v CHR 21，其中v为0〜3，R 21表示H，低级烷基或 G等表示-CO-，共价键等，m为0〜6，R7和R8表示H，低级烷基，-COR18a，-COOR20，其中R18a和R20各自表示低级烷基 或类似物等
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公开(公告)号：US07462630B2
公开(公告)日：2008-12-09
申请号：US10787175
申请日：2004-02-27
申请人： Takashi Yamamoto , Seiji Niwa , Kayo Otani , Seiji Ohno , Hajime Koganei , Satoshi Iwayama , Akira Takahara , Yukitsugu Ono , Tomoko Takeda , Shinichi Fujita , Keiko Moki
发明人： Takashi Yamamoto , Seiji Niwa , Kayo Otani , Seiji Ohno , Hajime Koganei , Satoshi Iwayama , Akira Takahara , Yukitsugu Ono , Tomoko Takeda , Shinichi Fujita , Keiko Moki
IPC分类号： A61K31/445 , C07D409/14
CPC分类号： C07D295/205 , C07C237/06 , C07C271/20 , C07C271/22 , C07D211/70 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D417/06
摘要： The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH═CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C═C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.
摘要翻译： 本发明涉及由以下通式（1）表示的化合物或其类似物，其选择性地抑制N-型钙通道或其类似物，以及涉及治疗疼痛等的方法，其包含由以下通式表示的化合物 1）或其与需要这种治疗的患者的类似物：其中A表示CH-CH等，a，b，c和d表示CH等，R 1，R 2，R 3，R 4，R 5和R 6表示H 等等，VW表示CC等，n表示0〜3，Y1表示O等，B表示 - （CH2）vCHR21，其中v为0-3，R21表示H，低级烷基等。 ，G表示-CO-，共价键等，m为0〜6，R7和R8表示H，低级烷基，-COR18a，-COOR20，其中R18a和R20各自表示低级烷基等， 等等
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公开(公告)号：US07326701B2
公开(公告)日：2008-02-05
申请号：US11398675
申请日：2006-04-06
申请人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
发明人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
IPC分类号： C07D487/04 , A61K31/5517 , A61P3/10
CPC分类号： C07D487/04 , A61K31/5517 , A61K31/554 , C07D243/10 , C07D513/04
摘要： An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
摘要翻译： 含有内酰胺化合物或其药学上可接受的盐的增加糖输送能力的药剂和用于预防和/或治疗糖尿病，糖尿病性周围神经病变，糖尿病性肾病，糖尿病性视网膜病变，糖尿病性大血管病变，葡萄糖耐量异常或脂肪变性的药剂 作为活性成分。
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公开(公告)号：US07632830B2
公开(公告)日：2009-12-15
申请号：US11948288
申请日：2007-11-30
申请人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
发明人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
IPC分类号： C07D487/04 , C07D498/04 , A61K31/5517 , A61P3/10
CPC分类号： C07D487/04 , A61K31/5517 , A61K31/554 , C07D243/10 , C07D513/04
摘要： An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
摘要翻译： 含有内酰胺化合物或其药学上可接受的盐的增加糖输送能力的药剂和用于预防和/或治疗糖尿病，糖尿病性周围神经病变，糖尿病性肾病，糖尿病性视网膜病变，糖尿病性大血管病变，葡萄糖耐量异常或脂肪变性的药剂 作为活性成分。
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公开(公告)号：US20080096862A1
公开(公告)日：2008-04-24
申请号：US11948288
申请日：2007-11-30
申请人： Yukio IINO , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
发明人： Yukio IINO , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
IPC分类号： A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P3/00 , C07D487/04 , C07D498/04 , C07D513/04
CPC分类号： C07D487/04 , A61K31/5517 , A61K31/554 , C07D243/10 , C07D513/04
摘要： An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
摘要翻译： 含有内酰胺化合物或其药学上可接受的盐的增加糖输送能力的药剂和用于预防和/或治疗糖尿病，糖尿病性周围神经病变，糖尿病性肾病，糖尿病性视网膜病变，糖尿病性大血管病变，葡萄糖耐量异常或脂肪变性的药剂 作为活性成分。
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公开(公告)号：US07153850B2
公开(公告)日：2006-12-26
申请号：US10449774
申请日：2003-06-02
申请人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
发明人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
IPC分类号： C07D487/04 , C07D498/04 , C07D513/04 , A61K31/5517 , A61P3/10
CPC分类号： C07D487/04 , A61K31/5517 , A61K31/554 , C07D243/10 , C07D513/04
摘要： An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
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公开(公告)号：US20060189597A1
公开(公告)日：2006-08-24
申请号：US11398675
申请日：2006-04-06
申请人： Yukio Ilno , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
发明人： Yukio Ilno , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
IPC分类号： A61K31/551 , C07D487/02
CPC分类号： C07D487/04 , A61K31/5517 , A61K31/554 , C07D243/10 , C07D513/04
摘要： An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
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公开(公告)号：US06930205B2
公开(公告)日：2005-08-16
申请号：US10740543
申请日：2003-12-22
IPC分类号： C07C213/02 , C07C217/84 , C07C211/43
CPC分类号： C07C213/02 , C07C217/84
摘要： The present invention relates to a novel process for preparing an aminostilbene derivative, which is important as an active component of anticancer drugs or an intermediate for preparation thereof, as well as methods of producing the same.
摘要翻译： 本发明涉及一种制备氨基芪衍生物的新方法，其作为抗癌药物或其制备中间体的活性成分是重要的，以及其制备方法。
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公开(公告)号：US10239106B2
公开(公告)日：2019-03-26
申请号：US14781151
申请日：2014-04-01
摘要： A spinning method includes supporting a supported portion of a cylindrical work by a work supporting portion; pressing a first roller of a spinning head against a processed portion of the work while revolving the first roller; and performing a forming process that points a tube axis of the processed portion of the work in a given direction by pressing the first roller and a second roller in which a plane of revolution thereof is provided in a different position, in a rotational axis direction of a spindle of the spinning head, than a plane of revolution of the first roller, while revolving the first roller and the second roller, and moving the work supporting portion relative to the spinning head or moving the spinning head relative to the work supporting portion, while the first roller and the second roller work in cooperation with each other to retain the work.
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