摘要:
Polysaccharides having antitumor and other useful pharmacological activities and a process for preparing such polysaccharides are disclosed. These polysaccharides are characterized by .alpha.-bonding of the saccharide component and can be produced from the extracts obtained by the extraction of a basidiomycetous fungus belonging to the genus Coriolus or cultures thereof with an aqueous solvent.
摘要:
Disclosed is a novel pharmaceutical composition having antitumor (anti-cancer) activity without causing pyrexia and anaphylaxis, formed by an amide bonding between an antibody obtained by the purification of the antibody to tumor (cancer) antigen via affinity-chromatography and an antitumor substance (anti-cancer drug).
摘要:
The present invention relates to a platinum compound having the formula ##STR1## wherein R represents hydrogen atom, an alkali metal atom or a lower alkyl group. The platinum compound is effective as an antitumor and antimicrobial drug.
摘要:
Disclosed herein are an anti-tumor substance obtained by bonding an anti-tumor agent to human immunoglobulin, and a process for producing the same.
摘要:
The present invention relates to a platinum compound having the formula ##STR1## wherein R represents hydrogen atom, an alkali metal atom or a lower alkyl group. The platinum compound is effective as an antitumor and antimicrobial drug.
摘要:
Disclosed herein are the derivatives of substituted cephalosporanic acid represented by the formula (I): ##STR1## wherein R.sup.1 represents a 4-pyridylthiomethyl group, an alpha-aminobenzyl group, a cyanomethyl group or a 1-tetrazolylmethyl group; R.sup.2 represents a hydrogen atom, an acetoxy group or a (5-methyl-1,3,4-thiadiazol-2-yl)thio group; R.sup.3 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1, n is 0, 1 or 2 and the carboxyl group may have been converted to a salt or an ester thereof; p is 0, 1 or 2 and X represents carbon atom or nitrogen atom, and antibiotics comprising the derivatives of substituted cephalosporanic acid represented by the formula (I).
摘要翻译:本文公开了由式(I)表示的取代的头孢烷酸的衍生物:其中R1表示4-吡啶硫基甲基,α-氨基苄基,氰基甲基或1-四唑基甲基; R2表示氢原子,乙酰氧基或(5-甲基-1,3,4-噻二唑-2-基)硫基; R 3表示氢原子,羟基,氨基甲酰基,具有1〜4个碳原子的烷基或 - (CONH)m(CH 2)n -COOH,其中m为0或1,n为0,1或2, 羧基可能已经转化为其盐或酯; p是0,1或2,X表示碳原子或氮原子,以及包含由式(I)表示的取代的头孢烷酸的衍生物的抗生素。
摘要:
Disclosed herein are an anti-tumor substance obtained by bonding an anti-tumor agent to human immunoglobulin, and a process for producing the same.
摘要:
Disclosed herein are a derivative of a substituted cephalosporanic acid, represented by the formula (I): ##STR1## wherein p is 0, 1 or 2 and R.sup.1 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1; n is 0, 1 or 2 and the carboxyl group may have been converted to the salt or the ester thereof, and an antibiotic comprising a derivative of substituted cephalosporanic acid represented by the formula (I).
摘要:
Disclosed is a novel pharmaceutical composition having antitumor activity without causing pyrexia and anaphylaxis formed by an amido bonding between an antibody obtained by the purification of the antibody to tumor antigen via affinity-chromatography and an antitumor substance.
摘要:
A compound having the general formula (I) is derived from a cephalosporin; ##STR1## wherein R' is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkali metal.A pharmaceutical composition containing the compound is excellent in an antibacterial activity, the activity being recovered by the action of an activating enzyme in a living body although the compound per se shows a low activity against the beneficial bacterial colonies in a living body.