公开(公告)号：US4663438A

公开(公告)日：1987-05-05

申请号：US715816

申请日：1985-03-25

申请人： Chikao Yoshikumi ,  Takayoshi Fujii ,  Takao Furusho ,  Kenichi Matsunaga ,  Minoru Ohara ,  Akira Kobayashi

发明人： Chikao Yoshikumi ,  Takayoshi Fujii ,  Takao Furusho ,  Kenichi Matsunaga ,  Minoru Ohara ,  Akira Kobayashi

IPC分类号： C12P21/00 ,  A61K36/07 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/37 ,  C07K14/375 ,  C07K14/41 ,  C12N1/00 ,  C12P1/06 ,  C12P9/00 ,  C07K15/14

CPC分类号： C07K14/375 ,  A61K38/00

摘要： Disclosed herein is a nucleic acid-containing glycoprotein having molecular weight of 5,000 to 300,000 as determined by ultracentrifugal method; the weight ratio of protein moiety thereof determined by Lowry-Folin's method to saccharide moiety thereof determined by phenol-sulfuric acid method of in the range of 50/50 to 80/20; N-terminal amino acid thereof consisting essentially of tyrosine, leucine or alanine; leucine-phenylalanine-valine as amino acid sequence at C-terminal thereof; the elementary composition consisting essentially of 35.2 to 49.3% of C, 4.8 to 8.0% of H, 4.3 to 12.3% of N, trace to 2.5% of S, trace to 1.2% of P and the balance of O; the isoelectric point of in the range of pH 2.5 to 5.0; and nucleic acid as a component.

摘要翻译： 本文公开了通过超速离心法测定的分子量为5,000〜300,000的含核酸的糖蛋白; 通过Lowry-Folin法测定的蛋白质部分的重量比通过酚 - 硫酸法测定的糖部分在50/50至80/20范围内; 其N-末端氨基酸主要由酪氨酸，亮氨酸或丙氨酸组成; 亮氨酸 - 苯丙氨酸 - 缬氨酸作为C末端的氨基酸序列; 基本组成基本上由C的35.2至49.3％，H的4.8至8.0％，N的4.3至12.3％，S的2.5％，P的1.2％和O的余量组成。 等电点在2.5〜5.0的范围内; 和核酸作为组分。

公开(公告)号：US4820689A

公开(公告)日：1989-04-11

申请号：US898900

申请日：1986-08-22

申请人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

发明人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

IPC分类号： A61K38/00 ,  C07K14/375 ,  A61K37/02 ,  A61K35/70

CPC分类号： C07K14/375 ,  A61K38/00 ,  Y10S435/911

摘要： Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretic activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.

摘要翻译： 本文公开了具有抗风湿活性，抗血栓活性，止痛活性，解热活性，抗高血脂活性和抗炎活性以及降低血糖水平的活性，提高冠状动脉血流量，提高变形能力的药物组合物 红细胞，降低血压，改善蛋白尿和蛋白血症，并以剂量​​单位形式调节哺乳动物中前列腺素的产生或代谢，其包括有效产生分子量为5000至300000的糖蛋白的活性的剂量，其通过超速离心 方法和约18〜38重量％的蛋白质，通过培养属于科氏菌属的嗜碱性真菌属真菌属物种，用热水或碱性水溶液提取如此增殖的菌丝体或果实体并除去分子量低的分子量物质 从不到5000 e提取。

公开(公告)号：US5008243A

公开(公告)日：1991-04-16

申请号：US285664

申请日：1988-12-16

申请人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

发明人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

IPC分类号： A61K38/00 ,  C07K14/375

CPC分类号： C07K14/375 ,  A61K38/00 ,  Y10S435/911

摘要： Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretics activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300,000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.

公开(公告)号：US4801581A

公开(公告)日：1989-01-31

申请号：US714354

申请日：1985-03-22

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing p-aminobenzoic acid-N-D-xyloside or a pharmaceutically a acceptable salt thereof as an active ingredient.

摘要翻译： 公开了含有对氨基苯甲酸-N-D-木糖苷或其药学上可接受的盐作为活性成分的药物组合物。

公开(公告)号：US4757054A

公开(公告)日：1988-07-12

申请号：US4308

申请日：1987-01-07

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70 ,  C08B37/00

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing p-aminobenzoic acid-N-D-xyloside or a pharmaceutically a acceptable salt thereof as an active ingredient.

摘要翻译： 公开了含有对氨基苯甲酸-N-D-木糖苷或其药学上可接受的盐作为活性成分的药物组合物。

公开(公告)号：US4555505A

公开(公告)日：1985-11-26

申请号：US584629

申请日：1984-02-29

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a method for the treatment of hyperglycemia, hyperlipemia, inflammatory diseases, pains due to the accentuation of central nerve, pyrexia due to the accentuation of central nerve or tumor, which comprises administering to a patient suffering therefrom a pharmaceutically effective amount of p-aminobenzoic acid-N-L-rhamnoside or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明公开了一种治疗高血糖症，高脂血症，炎症性疾病，由于中枢神经突出而引起的疼痛，由于中枢神经或肿瘤引起的发热，其包括向患有其的药物有效量的对 - 氨基苯甲酸-NL-鼠李糖苷或其药学上可接受的盐。

公开(公告)号：US4614733A

公开(公告)日：1986-09-30

申请号：US646433

申请日：1984-08-31

申请人： Chikao Yoshikumi ,  Takayoshi Fujii ,  Masahiko Fujii ,  Minoru Ohara ,  Akira Kobayashi ,  Tsuneo Akatsu

发明人： Chikao Yoshikumi ,  Takayoshi Fujii ,  Masahiko Fujii ,  Minoru Ohara ,  Akira Kobayashi ,  Tsuneo Akatsu

IPC分类号： A61K31/715 ,  C08B37/00

CPC分类号： A61K31/715

摘要： Polysaccharides having antitumor and other useful pharmacological activities and a process for preparing such polysaccharides are disclosed. These polysaccharides are characterized by .alpha.-bonding of the saccharide component and can be produced from the extracts obtained by the extraction of a basidiomycetous fungus belonging to the genus Coriolus or cultures thereof with an aqueous solvent.

摘要翻译： 公开了具有抗肿瘤和其它有用的药理活性的多糖和制备这种多糖的方法。 这些多糖的特征在于糖组分的α-键结合，并且可以由通过用水性溶剂萃取属于Coriolus的basidiomycetous真菌或其培养物获得的提取物生产。

公开(公告)号：US4681877A

公开(公告)日：1987-07-21

申请号：US562003

申请日：1983-12-16

申请人： Shigeaki Muto ,  Takao Ando ,  Takayoshi Fujii ,  Akihiko Kanno ,  Yoko Onishi ,  Isamu Motokawa ,  Takao Furusho ,  Chikao Yoshikumi

发明人： Shigeaki Muto ,  Takao Ando ,  Takayoshi Fujii ,  Akihiko Kanno ,  Yoko Onishi ,  Isamu Motokawa ,  Takao Furusho ,  Chikao Yoshikumi

IPC分类号： A61K31/545 ,  C07D501/36 ,  C07D501/56

CPC分类号： C07D501/36

摘要： Disclosed herein are 7-beta-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-(2-amino-1,3,4-thiadiazolyl-5-thiomethyl)-3-cepheme-4-carboxylic acid, salts thereof and pivaloyloxymethyl ester thereof, and a pharmaceutical composition containing the same as an active ingredient.

摘要翻译： 本文公开了7-β-（2-（2-氨基-4-噻唑基）-2-甲氧基亚氨基乙酰氨基] -3-（2-氨基-1,3,4-噻二唑基-5-硫代甲基）-3-头孢烯-4 - 羧酸，其盐和新戊酰氧基甲酯，以及含有它们作为活性成分的药物组合物。

公开(公告)号：US4758558A

公开(公告)日：1988-07-19

申请号：US864574

申请日：1986-05-19

申请人： Akihiko Kanno ,  Shigeaki Muto ,  Koichi Niimura ,  Takao Ando ,  Takayoshi Fujii ,  Masahiko Fujii ,  Takao Furusho ,  Chikao Yoshikumi

发明人： Akihiko Kanno ,  Shigeaki Muto ,  Koichi Niimura ,  Takao Ando ,  Takayoshi Fujii ,  Masahiko Fujii ,  Takao Furusho ,  Chikao Yoshikumi

IPC分类号： A61K31/545 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/26 ,  C07D501/28 ,  C07D501/36

CPC分类号： C07D501/20

摘要： Disclosed herein are the derivatives of substituted cephalosporanic acid represented by the formula (I): ##STR1## wherein R.sup.1 represents a 4-pyridylthiomethyl group, an alpha-aminobenzyl group, a cyanomethyl group or a 1-tetrazolylmethyl group; R.sup.2 represents a hydrogen atom, an acetoxy group or a (5-methyl-1,3,4-thiadiazol-2-yl)thio group; R.sup.3 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1, n is 0, 1 or 2 and the carboxyl group may have been converted to a salt or an ester thereof; p is 0, 1 or 2 and X represents carbon atom or nitrogen atom, and antibiotics comprising the derivatives of substituted cephalosporanic acid represented by the formula (I).

摘要翻译： 本文公开了由式（I）表示的取代的头孢烷酸的衍生物：其中R1表示4-吡啶硫基甲基，α-氨基苄基，氰基甲基或1-四唑基甲基; R2表示氢原子，乙酰氧基或（5-甲基-1,3,4-噻二唑-2-基）硫基; R 3表示氢原子，羟基，氨基甲酰基，具有1〜4个碳原子的烷基或 - （CONH）m（CH 2）n -COOH，其中m为0或1，n为0,1或2， 羧基可能已经转化为其盐或酯; p是0,1或2，X表示碳原子或氮原子，以及包含由式（I）表示的取代的头孢烷酸的衍生物的抗生素。

公开(公告)号：US4734409A

公开(公告)日：1988-03-29

申请号：US702135

申请日：1985-02-15

申请人： Shigeaki Muto ,  Chikao Yoshikumi ,  Takao Furusho ,  Isamu Motokawa ,  Yoko Onishi ,  Akihiko Kanno ,  Takayoshi Fujii ,  Takao Ando

发明人： Shigeaki Muto ,  Chikao Yoshikumi ,  Takao Furusho ,  Isamu Motokawa ,  Yoko Onishi ,  Akihiko Kanno ,  Takayoshi Fujii ,  Takao Ando

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/36

CPC分类号： C07D501/36

摘要： Disclosed herein are a cephalosporin derivative represented by the formula (I): ##STR1## wherein R.sup.1 represents a halogenoalkyl group, a salt and ester thereof, a process for producing the same, and a pharmaceutical composition and an antibacterial agent comprising the same.

摘要翻译： 本文公开了由式（I）表示的头孢菌素衍生物：其中R 1表示卤代烷基，其盐和酯，其制备方法，药物组合物和抗菌剂 包含其的药剂。