公开(公告)号：US07491836B2

公开(公告)日：2009-02-17

申请号：US10553275

申请日：2004-04-13

申请人： Christian von Corswant ,  Karl Hult ,  Erik Söderlind ,  Fredrik Viklund

发明人： Christian von Corswant ,  Karl Hult ,  Erik Söderlind ,  Fredrik Viklund

IPC分类号： C07C59/00

CPC分类号： A61K9/02 ,  A61K9/0019 ,  A61K9/2031 ,  A61K9/4866 ,  C08G65/3322 ,  C12P7/62

摘要： New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatty acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene/alkyl polyoxyalkylene chain with a chain-length of 25-455 repeating units and a specified substituent on the hydroxy position of the specified hydroxy fatty acid, according to the general formula (I) CH3—(CH2)x—CH—(CH2)y—CO—[—O—R3—]z—O—R1 R2—O (I); wherein for example R1 is methyl, R2 is optionally substituted C14-C22 acyl, alkyl, or alkenyl, R3 is ethylene, x is 2-12, y is 7-17, (x+y) is 3-19 and z is 25-57; advantageously prepared by involving an enzymatic process, formulations comprising them, their use as solubilizers and a process involving a hydrolytic enzyme for preparing them.

摘要翻译： 具有聚氧亚烷基二醇羟基脂肪酸衍生物或单烷基化聚氧亚烷基二醇羟基脂肪酸衍生物的新型非离子表面活性剂，其具有链长为25-455个重复单元的聚氧化烯/烷基聚氧化烯链和羟基位置上的特定取代基 根据通式（I）CH 3 - （CH 2）x -CH-（CH 2）y -CO - [ - O-R 3 - ] z O-R 1 R 2 -O（I）的特定羟基脂肪酸; 其中例如R 1是甲基，R 2是任选取代的C 14 -C 22酰基，烷基或烯基，R 3是亚乙基，x是2-12，y是7-17，（x + y）是3-19，z是25 -57; 有利地通过涉及酶法制备，包含它们的制剂，它们作为增溶剂的用途和涉及用于制备它们的水解酶的方法。

公开(公告)号：US20060287542A1

公开(公告)日：2006-12-21

申请号：US10553275

申请日：2004-04-13

申请人： Christian von Corswant ,  Karl Hult ,  Erik Soderlind ,  Fredrik Viklund

发明人： Christian von Corswant ,  Karl Hult ,  Erik Soderlind ,  Fredrik Viklund

IPC分类号： C07C255/28 ,  C07C229/02

CPC分类号： A61K9/02 ,  A61K9/0019 ,  A61K9/2031 ,  A61K9/4866 ,  C08G65/3322 ,  C12P7/62

摘要： New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatty acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene / alkyl polyoxyalkylene chain with a chain-length of 25-455 repeating units and a specified substituent on the hydroxy position of the specified hydroxy fatty acid, according to the general formula (I) CH3—(CH2)x—CH—(CH2)y—CO—[—O—R3—]z—O—R1 R2—O (I); wherein for example R1 is methyl, R2 is optionally substituted C14—C22 acyl, alkyl, or alkenyl, R3 is ethylene, x is 2-12, y is 7-17, (x+y) is 3-19 and z is 25-57; advantageously prepared by involving an enzymatic process, formulations comprising them, their use as solubilizers and a process involving a hydrolytic enzyme for preparing them.

摘要翻译： 具有聚氧亚烷基二醇羟基脂肪酸衍生物或单烷基化聚氧亚烷基二醇羟基脂肪酸衍生物的新型非离子表面活性剂，其具有链长为25-455个重复单元的聚氧化烯/烷基聚氧化烯链和羟基位置上的特定取代基 指定的羟基脂肪酸，根据通式（I）CH 3 - （CH 2）x - CH-（CH _{- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -O（I）; 其中例如R 1是甲基，R 2是任选取代的C 14 -C 22酰基，烷基， 或链烯基，R 3是亚乙基，x是2-12，y是7-17，（x + y）是3-19，z是25-57; 有利地通过涉及酶法制备，包含它们的制剂，它们作为增溶剂的用途和涉及用于制备它们的水解酶的方法。}