Non-ionic surfactants for solubilizing poorly solubule molecules
    1.
    发明申请
    Non-ionic surfactants for solubilizing poorly solubule molecules 有权
    用于溶解不良溶解分子的非离子表面活性剂

    公开(公告)号:US20060287542A1

    公开(公告)日:2006-12-21

    申请号:US10553275

    申请日:2004-04-13

    IPC分类号: C07C255/28 C07C229/02

    摘要: New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatty acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene / alkyl polyoxyalkylene chain with a chain-length of 25-455 repeating units and a specified substituent on the hydroxy position of the specified hydroxy fatty acid, according to the general formula (I) CH3—(CH2)x—CH—(CH2)y—CO—[—O—R3—]z—O—R1 R2—O (I); wherein for example R1 is methyl, R2 is optionally substituted C14—C22 acyl, alkyl, or alkenyl, R3 is ethylene, x is 2-12, y is 7-17, (x+y) is 3-19 and z is 25-57; advantageously prepared by involving an enzymatic process, formulations comprising them, their use as solubilizers and a process involving a hydrolytic enzyme for preparing them.

    摘要翻译: 具有聚氧亚烷基二醇羟基脂肪酸衍生物或单烷基化聚氧亚烷基二醇羟基脂肪酸衍生物的新型非离子表面活性剂,其具有链长为25-455个重复单元的聚氧化烯/烷基聚氧化烯链和羟基位置上的特定取代基 指定的羟基脂肪酸,根据通式(I)CH 3 - (CH 2)x - CH-(CH - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -O(I); 其中例如R 1是甲基,R 2是任选取代的C 14 -C 22酰基,烷基, 或链烯基,R 3是亚乙基,x是2-12,y是7-17,(x + y)是3-19,z是25-57; 有利地通过涉及酶法制备,包含它们的制剂,它们作为增溶剂的用途和涉及用于制备它们的水解酶的方法。

    Non-ionic surfactants for poorly soluble molecules
    2.
    发明授权
    Non-ionic surfactants for poorly soluble molecules 有权
    用于难溶性分子的非离子表面活性剂

    公开(公告)号:US07491836B2

    公开(公告)日:2009-02-17

    申请号:US10553275

    申请日:2004-04-13

    IPC分类号: C07C59/00

    摘要: New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatty acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene/alkyl polyoxyalkylene chain with a chain-length of 25-455 repeating units and a specified substituent on the hydroxy position of the specified hydroxy fatty acid, according to the general formula (I) CH3—(CH2)x—CH—(CH2)y—CO—[—O—R3—]z—O—R1 R2—O (I); wherein for example R1 is methyl, R2 is optionally substituted C14-C22 acyl, alkyl, or alkenyl, R3 is ethylene, x is 2-12, y is 7-17, (x+y) is 3-19 and z is 25-57; advantageously prepared by involving an enzymatic process, formulations comprising them, their use as solubilizers and a process involving a hydrolytic enzyme for preparing them.

    摘要翻译: 具有聚氧亚烷基二醇羟基脂肪酸衍生物或单烷基化聚氧亚烷基二醇羟基脂肪酸衍生物的新型非离子表面活性剂,其具有链长为25-455个重复单元的聚氧化烯/烷基聚氧化烯链和羟基位置上的特定取代基 根据通式(I)CH 3 - (CH 2)x -CH-(CH 2)y -CO - [ - O-R 3 - ] z O-R 1 R 2 -O(I)的特定羟基脂肪酸; 其中例如R 1是甲基,R 2是任选取代的C 14 -C 22酰基,烷基或烯基,R 3是亚乙基,x是2-12,y是7-17,(x + y)是3-19,z是25 -57; 有利地通过涉及酶法制备,包含它们的制剂,它们作为增溶剂的用途和涉及用于制备它们的水解酶的方法。

    Microemulsions for use as vehicles for administration of active compounds
    3.
    发明授权
    Microemulsions for use as vehicles for administration of active compounds 失效
    用作施用活性化合物的载体的微乳液

    公开(公告)号:US06602511B2

    公开(公告)日:2003-08-05

    申请号:US08718485

    申请日:1996-09-30

    IPC分类号: A61K9107

    CPC分类号: A61K9/1075 Y10S514/941

    摘要: A non-toxic oil-in-water or bicontinous microemulsion used as a pharmaceutically acceptable vehicle for administration of one or more active compounds having a low solubility in water as well as a process for the preparation and the use thereof.

    摘要翻译: 用作一种或多种在水中溶解度低的活性化合物的药学上可接受的载体的无毒的水包油或双联微乳液以及其制备方法和用途。