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公开(公告)号:US20120190666A1
公开(公告)日:2012-07-26
申请号:US13319683
申请日:2010-05-12
申请人: Christiane Bode , Alessandro Boezio , Alan C. Cheng , Deborah Choquette , James Robert Coats , Katrina Woodin Copeland , Hongbing Huang , Daniel La , Richard Thomas Lewis , Hongyu Liao , Michele Potashman , John Stellwagen , Shuyan Yi , Mark H. Norman , Markian M. Stec , Emily Anne Peterson , Russell Graceffa
发明人: Christiane Bode , Alessandro Boezio , Alan C. Cheng , Deborah Choquette , James Robert Coats , Katrina Woodin Copeland , Hongbing Huang , Daniel La , Richard Thomas Lewis , Hongyu Liao , Michele Potashman , John Stellwagen , Shuyan Yi , Mark H. Norman , Markian M. Stec , Emily Anne Peterson , Russell Graceffa
IPC分类号: A61K31/52 , C07D401/14 , A61K31/506 , A61P35/02 , A61K31/53 , C07D487/04 , A61K31/5377 , A61P35/00 , C07D473/40 , C07D471/04
CPC分类号: C07D401/14 , C07D403/04 , C07D403/14 , C07D471/04 , C07D487/04 , C07D519/00
摘要: The present invention provides compounds that are PIKK inhibitors, more specifically, mTOR and/or PI3Kα kinase inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of kinases, specifically PI3 kinases, more specifically, mTOR and/or PI3Kα, such as cancer. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译: 本发明提供了PIKK抑制剂,更具体地,mTOR和/或PI3Kα激酶抑制剂的化合物,因此可用于治疗通过抑制激酶可治疗的疾病,特别是PI3激酶,更具体地,mTOR和/或PI3Kα,例如 癌症。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。