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    Amphipathic Co-Oligomers for the Delivery of SIRNA
    2.
    发明申请
    Amphipathic Co-Oligomers for the Delivery of SIRNA 有权
    用于输送SIRNA的两亲性共低聚物

    公开(公告)号：US20140350077A1

    公开(公告)日：2014-11-27

    申请号：US14342480

    申请日：2012-09-05

    申请人： Christina Barnes Cooley ,  Erika Geihe Stanzl ,  Robert M. Waymouth ,  Paul Wender

    发明人： Christina Barnes Cooley ,  Erika Geihe Stanzl ,  Robert M. Waymouth ,  Paul Wender

    IPC分类号： C12N15/113

    CPC分类号： C12N15/113 ,  A61K9/0019 ,  A61K47/593 ,  C12N2310/14 ,  C12N2320/32

    摘要： Co-oligomer compounds, complexes of the same with polyanions, such as siRNAs, and methods for using the same are provided. the delivery of polynucleotides, into a cell. The subject co-oligomers include at least a liphopilic monomer and at least a hydrophilic monomer (e.g., a guanidinium containing monomer). In some embodiments, the co-oligomer compounds are capable of complexing a siRNA of interest, thereby increasing the cell permeability of the siRNA, prior to release of the siRNA into the cell. In some embodiments, the subject method is a method of delivery a siRNA into a cell. In some embodiments, the subject method is a method of reducing expression of a protein target of a siRNA of interest. The subject co-oligomer/siRNA complexes may be formulated and administered to a subject to treat a condition resulting from expression of a protein target of the siRNA of interest.

    摘要翻译： 提供了共低聚物化合物，与聚阴离子的复合物，如siRNAs，以及使用它们的方法。 将多核苷酸递送到细胞中。 本发明共低聚物包括至少一种亲脂单体和至少一种亲水单体（例如含有胍基的单体）。 在一些实施方案中，在将siRNA释放到细胞之前，共低聚物化合物能够络合感兴趣的siRNA，从而增加siRNA的细胞通透性。 在一些实施方案中，本发明方法是将siRNA递送至细胞的方法。 在一些实施方案中，本发明方法是减少感兴趣的siRNA的蛋白质靶标的表达的方法。 可以将受试者共同寡聚体/ siRNA复合物配制并施用于受试者以治疗由感兴趣的siRNA的蛋白质靶标表达产生的病症。

    Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents
    3.
    发明授权
    Catalytic depolymerization of polymers containing electrophilic linkages using nucleophilic reagents 失效
    使用亲核试剂催化解聚包含亲电键的聚合物

    公开(公告)号：US07544800B2

    公开(公告)日：2009-06-09

    申请号：US11208268

    申请日：2005-08-18

    申请人： James Lupton Hedrick ,  Gregory Walker Nyce ,  Robert M. Waymouth

    发明人： James Lupton Hedrick ,  Gregory Walker Nyce ,  Robert M. Waymouth

    IPC分类号： C07F1/00

    CPC分类号： C07D233/16 ,  C07C59/285 ,  C07C67/03 ,  C07C68/06 ,  C07D233/02 ,  C07D233/04 ,  C07D233/06 ,  C07D233/54 ,  C07D307/33 ,  C07F1/00 ,  C07C69/82 ,  C07C69/96

    摘要： A method is provided for carrying out depolymerization of a polymer containing electrophilic linkages in the presence of a catalyst and a nucleophilic reagent, wherein production of undesirable byproducts resulting from polymer degradation is minimized. The reaction can be carried out at a temperature of 80° C. or less, and generally involves the use of an organic, nonmetallic catalyst, thereby ensuring that the depolymerization product(s) are substantially free of metal contaminants. In an exemplary depolymerization method, the catalyst is a carbene compound such as an N-heterocyclic carbene, or is a precursor to a carbene compound. The method provides an important alternative to current recycling techniques such as those used in the degradation of polyesters, polyamides, and the like.

    摘要翻译： 提供了一种在催化剂和亲核试剂的存在下进行含有亲电键的聚合物解聚的方法，其中由聚合物降解产生的不需要的副产物的产生最小化。 反应可以在80℃或更低的温度下进行，通常涉及使用有机非金属催化剂，从而确保解聚产物基本上不含金属污染物。 在示例性的解聚方法中，催化剂是卡宾化合物如N-杂环卡宾，或是卡宾化合物的前体。 该方法提供了当前回收技术的重要替代方法，例如用于降解聚酯，聚酰胺等的那些。

    Heteroatom-stabilized carbenes and precursors thereto as depolymerization catalysts
    7.
    发明授权
    Heteroatom-stabilized carbenes and precursors thereto as depolymerization catalysts 有权
    杂原子稳定的卡宾及其前体作为解聚催化剂

    公开(公告)号：US07053221B2

    公开(公告)日：2006-05-30

    申请号：US10355554

    申请日：2003-01-30

    申请人： James Lupton Hedrick ,  Gregory Walker Nyce ,  Robert M. Waymouth

    发明人： James Lupton Hedrick ,  Gregory Walker Nyce ,  Robert M. Waymouth

    IPC分类号： C07D277/14

    CPC分类号： C07D233/16 ,  C07C59/285 ,  C07C67/03 ,  C07C68/06 ,  C07D233/02 ,  C07D233/04 ,  C07D233/06 ,  C07D233/54 ,  C07D307/33 ,  C07F1/00 ,  C07C69/82 ,  C07C69/96

    摘要： A method is provided for carrying out depolymerization of a polymer containing electrophilic linkages in the presence of a catalyst and a nucleophilic reagent, wherein production of undesirable byproducts resulting from polymer degradation is minimized. The reaction can be carried out at a temperature of 80° C. or less, and generally involves the use of an organic, nonmetallic catalyst, thereby ensuring that the depolymerization product(s) are substantially free of metal contaminants. In an exemplary depolymerization method, the catalyst is a carbene compound such as an N-heterocyclic carbene, or is a precursor to a carbene compound. The method provides an important alternative to current recycling techniques such as those used in the degradation of polyesters, polyamides, and the like.

    摘要翻译： 提供了一种在催化剂和亲核试剂的存在下进行含有亲电键的聚合物解聚的方法，其中由聚合物降解产生的不需要的副产物的产生最小化。 反应可以在80℃或更低的温度下进行，通常涉及使用有机非金属催化剂，从而确保解聚产物基本上不含金属污染物。 在示例性的解聚方法中，催化剂是卡宾化合物如N-杂环卡宾，或是卡宾化合物的前体。 该方法提供了当前回收技术的重要替代方法，例如用于降解聚酯，聚酰胺等的那些。

    Catalysts for thermoplastic elastomeric olefin polymers
    8.
    发明授权
    Catalysts for thermoplastic elastomeric olefin polymers 失效
    用于热塑性弹性体烯烃聚合物的催化剂

    公开(公告)号：US06566544B1

    公开(公告)日：2003-05-20

    申请号：US09110691

    申请日：1998-07-07

    申请人： Robert M. Waymouth ,  Elisabeth Hauptman ,  Geoffrey W. Coates

    发明人： Robert M. Waymouth ,  Elisabeth Hauptman ,  Geoffrey W. Coates

    IPC分类号： C07F1700

    CPC分类号： C08F110/00 ,  C08F4/61908 ,  C08F4/61912 ,  C08F4/65925 ,  C08F10/00 ,  C08F10/06 ,  C08F110/02 ,  C08F110/06 ,  C08F110/14 ,  Y02P20/52 ,  Y10S526/943 ,  Y10S977/788 ,  C08F4/61925 ,  C08F2500/04 ,  C08F2500/21 ,  C08F2500/03 ,  C08F2500/12 ,  C08F2500/15

    摘要： This invention is directed to novel catalysts the structure and activity of which can be controlled to produce a wide range of alpha olefin polymers and co-polymers, and preferably for the production of stereoblock poly alpha olefins comprising a wide range of preselected amorphous and crystalline segments for precise control of the physical properties thereof, principally elastomeric thermoplastic properties. More specifically, this invention is directed to novel catalysts and catalysts systems for producing stereoblock polypropylene comprising alternating isotactic and atactic diastereosequences, which result in a wide range of elastomeric properties. The amount and numbers of crystalline sections, the isotactic pentad content, the number and length of intermediate atactic chains and overall molecular weight are all controllable by the steric structure of the catalysts and the process conditions. The novel catalysts provided by the present invention are ligand-bearing non-rigid metallocenes the geometry of which can be controlled on a time scale that is slower than the rate of olefin insertion, but faster than the average time to construct (polymerize) a single polymer chain, in order to obtain a stereoblock structure in the produced polyolefins. The symmetry of the catalyst structure is such that upon isomerization the catalyst symmetry alternates between a chiral and an achiral geometry. This geometry alteration can be controlled by selecting ligand type and structure, and through control of polymerization conditions to precisely control the physical properties of the resulting polymers.

    摘要翻译： 本发明涉及新型催化剂，其结构和活性可以被控制以产生大范围的α-烯烃聚合物和共聚物，并且优选用于制备包含宽范围的预选非晶和结晶链段的立体嵌段聚α-烯烃 用于精确控制其物理性能，主要是弹性体热塑性质。 更具体地，本发明涉及用于生产立体异构聚丙烯的新型催化剂和催化剂体系，其包括交替的全同立构和无规立构非对映异构体，其导致宽范围的弹性体性质。 结晶部分的数量和数量，全同立构五单元组含量，中间无规链的数量和长度以及总分子量都可以通过催化剂的空间结构和工艺条件来控制。 由本发明提供的新型催化剂是配体的非刚性金属茂，其几何形状可以在比烯烃插入速率慢的时间尺度上控制，但比构建（聚合）单一的 聚合物链，以获得所生产的聚烯烃中的立体嵌段结构。 催化剂结构的对称性使得在异构化时，催化剂对称性在手性和非手性几何形状之间交替。 可以通过选择配体类型和结构以及通过控制聚合条件来精确控制所得聚合物的物理性质来控制这种几何变化。