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公开(公告)号：US5620953A
公开(公告)日：1997-04-15
申请号：US447664
申请日：1995-05-23
申请人： Christine L. Cannova , Michael A. Goetz , Anne W. Dombrowski , Sandra J. Rattray , Sheo B. Singh , Gerald F. Bills , Jon Polishook , Joyce A. Greene , Gary K. Darland
发明人： Christine L. Cannova , Michael A. Goetz , Anne W. Dombrowski , Sandra J. Rattray , Sheo B. Singh , Gerald F. Bills , Jon Polishook , Joyce A. Greene , Gary K. Darland
IPC分类号： A61K38/00 , A61P29/00 , A61P33/02 , C07K5/12 , C12N1/14 , C12P21/04 , C12R1/77 , A61K38/12 , A61K31/445 , C07D471/04
摘要： The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis.
摘要翻译： 本发明提供了可用于治疗或预防原生动物疾病的新型环状四肽; 特别是新型化合物对疟疾，弓形虫病和球虫病引起的病原体具有抗性。
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公开(公告)号：US5861375A
公开(公告)日：1999-01-19
申请号：US789931
申请日：1997-01-28
申请人： Christine Lange Cannova , Anne W. Dombrowski , Michael A. Goetz , Sandra J. Rattray , Sheo Bux Singh , Jon Polishook , Gerald F. Bills , Joyce A. Greene , Gary K. Darland
发明人： Christine Lange Cannova , Anne W. Dombrowski , Michael A. Goetz , Sandra J. Rattray , Sheo Bux Singh , Jon Polishook , Gerald F. Bills , Joyce A. Greene , Gary K. Darland
IPC分类号： A61K38/00 , A61P29/00 , A61P33/02 , C07K5/12 , C12N1/14 , C12P21/04 , C12R1/77 , A61K38/12 , A61K31/445 , C07D471/04
摘要： The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis.
摘要翻译： 本发明提供了可用于治疗或预防原生动物疾病的新型环状四肽; 特别是新型化合物对疟疾，弓形虫病和球虫病引起的病原体具有抗性。
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公开(公告)号：US06428983B1
公开(公告)日：2002-08-06
申请号：US09296834
申请日：1999-04-22
IPC分类号： C12N2106
CPC分类号： G01N33/6875 , A61K38/005 , A61K38/12 , C07K5/126 , C12Q1/025 , C12Q1/18 , G01N2333/445 , G01N2333/455 , Y02A50/411 , Y10S514/895
摘要： Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.
摘要翻译： 组蛋白脱乙酰酶抑制提供了鉴定潜在的抗原生动物化合物的靶标。 组蛋白脱乙酰酶抑制剂可用作抗原生动物感染的治疗剂。
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公开(公告)号：US6110697A
公开(公告)日：2000-08-29
申请号：US716978
申请日：1996-09-20
CPC分类号： G01N33/6875 , A61K38/005 , A61K38/12 , C07K5/126 , C12Q1/025 , C12Q1/18 , G01N2333/445 , G01N2333/455 , Y10S514/895
摘要： Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.
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5.发明授权Toxoplasma gondii cylclic GMP dependent protein kinase G as a chemotherapeutic target for antiprotozoal agents 有权弓形虫圆环GMP依赖性蛋白激酶G作为抗原虫药的化疗靶标公开(公告)号：US07718390B2
公开(公告)日：2010-05-18
申请号：US11525062
申请日：2006-09-21
申请人： Anne Gurnett , Robert Donald , Georgianna Harris , Paul A. Liberator , Dennis Schmatz , Sandra J. Rattray
发明人： Anne Gurnett , Robert Donald , Georgianna Harris , Paul A. Liberator , Dennis Schmatz , Sandra J. Rattray
CPC分类号： C12N9/1205 , C12Q1/18 , C12Q1/485 , G01N2333/45
摘要： Protozoal cyclic GMP dependent protein kinases have been isolated and cloned. These enzymes may be used in screening assays to identify potential antiprotozoal agents.
摘要翻译： 原始循环GMP依赖性蛋白激酶已被分离和克隆。 这些酶可用于筛选测定以鉴定潜在的抗原虫药。
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公开(公告)号：US6068987A
公开(公告)日：2000-05-30
申请号：US443003
申请日：1999-11-18
CPC分类号： C12Q1/025 , G01N33/6875 , G01N2333/445 , G01N2333/455 , Y10S514/895
摘要： Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.
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7.发明授权Cyclic GMP dependent protein kinase as a chemotherapeutic target for antiprotozoal agents 有权循环GMP依赖性蛋白激酶作为抗原虫剂的化疗靶标公开(公告)号：US07125700B2
公开(公告)日：2006-10-24
申请号：US10348155
申请日：2003-01-21
申请人： Anne Gurnett , Robert Donald , Georgianna Harris , Paul A. Liberator , Dennis Schmatz , Sandra J. Rattray
发明人： Anne Gurnett , Robert Donald , Georgianna Harris , Paul A. Liberator , Dennis Schmatz , Sandra J. Rattray
IPC分类号： C12N9/12
CPC分类号： C12N9/1205 , C12Q1/18 , C12Q1/485 , G01N2333/45
摘要： Protozoal cyclic GMP dependent protein kinases have been isolated and cloned. These enzymes may be used in screening assays to identify potential antiprotozoal agents.
摘要翻译： 原始循环GMP依赖性蛋白激酶已被分离和克隆。 这些酶可用于筛选测定以鉴定潜在的抗原虫药。
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8.发明授权公开(公告)号：US06555358B1
公开(公告)日：2003-04-29
申请号：US09521511
申请日：2000-03-08
申请人： Anne Gurnett , Paul A. Liberator , Robert Donald , Dennis Schmatz , Georgianna Harris , Sandra J. Rattray
发明人： Anne Gurnett , Paul A. Liberator , Robert Donald , Dennis Schmatz , Georgianna Harris , Sandra J. Rattray
IPC分类号： C12N110
CPC分类号： C12N9/1205 , C12Q1/18 , C12Q1/485 , G01N2333/45
摘要： Protozoal cyclic GMP dependent protein kinases have been isolated and cloned. These enzymes may be used in screening assays to identify potential antiprotozoal agents.
摘要翻译： 原始循环GMP依赖性蛋白激酶已被分离和克隆。 这些酶可用于筛选测定以鉴定潜在的抗原虫药。
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公开(公告)号：US5922837A
公开(公告)日：1999-07-13
申请号：US789347
申请日：1997-01-27
摘要： The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis. The invention also relates to the use of known compounds which are histone deacetylase inhibitors as antiprotozoal agents.
摘要翻译： 本发明提供了可用于治疗或预防原生动物疾病的新型环状四肽; 特别是新型化合物对疟疾，弓形虫病和球虫病引起的病原体具有抗性。 本发明还涉及作为组蛋白脱乙酰酶抑制剂的已知化合物作为抗原虫剂的用途。
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