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公开(公告)号:US08663603B2
公开(公告)日:2014-03-04
申请号:US12888736
申请日:2010-09-23
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
IPC分类号: A61B8/00
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译: 本发明提供用于治疗和诊断应用的组合物和方法。
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公开(公告)号:US07910088B2
公开(公告)日:2011-03-22
申请号:US11688968
申请日:2007-03-21
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield , Feng Yan
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield , Feng Yan
IPC分类号: A61B8/00
CPC分类号: A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译: 本发明提供用于治疗和诊断应用的组合物和方法。
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公开(公告)号:US20110070165A1
公开(公告)日:2011-03-24
申请号:US12888736
申请日:2010-09-23
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译: 本发明提供用于治疗和诊断应用的组合物和方法。
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4.KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy 有权
标题翻译: KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号:US08642010B2
公开(公告)日:2014-02-04
申请号:US12480578
申请日:2009-06-08
申请人: Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
发明人: Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
CPC分类号: A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译: 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽,肽二聚体和多聚体复合物,其具有各种用途,无论何处治疗,检测,分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力(例如具有KD <1μM)结合KDR或VEGF / KDR复合物的合成,分离的多肽,以及包含这些多肽的二聚体和多聚体构建体。
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5.KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 有权
标题翻译: KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号:US20110097275A1
公开(公告)日:2011-04-28
申请号:US12898119
申请日:2010-10-05
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan
CPC分类号: A61K49/221 , A61K38/00 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/58
摘要: The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译: 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽,肽二聚体和多聚体复合物,其具有各种用途,无论何处治疗,检测,分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力(例如具有KD <1μM)结合KDR或VEGF / KDR复合物的合成,分离的多肽,以及包含这些多肽,特别是造影剂的二聚体和多聚体构建体。 还提供了使用本发明的造影剂监测和评估与血管生成或内皮细胞过度增殖相关的疾病(例如癌症)的治疗方案的治疗有效性的方法。
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6.KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy 有权
标题翻译: KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号:US08623822B2
公开(公告)日:2014-01-07
申请号:US12898119
申请日:2010-10-05
申请人: Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan
发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan
IPC分类号: C07K14/00
CPC分类号: A61K49/221 , A61K38/00 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/58
摘要: The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译: 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽,肽二聚体和多聚体复合物,其具有各种用途,无论何处治疗,检测,分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力(例如具有KD <1μM)结合KDR或VEGF / KDR复合物的合成,分离的多肽,以及包含这些多肽,特别是造影剂的二聚体和多聚体构建体。 还提供了使用本发明的造影剂监测和评估与血管生成或内皮细胞过度增殖相关的疾病(例如癌症)的治疗方案的治疗有效性的方法。
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公开(公告)号:US08632753B2
公开(公告)日:2014-01-21
申请号:US12972965
申请日:2010-12-20
申请人: Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人: Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
CPC分类号: A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
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公开(公告)号:US20110286929A1
公开(公告)日:2011-11-24
申请号:US12972965
申请日:2010-12-20
申请人: Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人: Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
CPC分类号: A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要: The invention provides compositions and methods for therapeutic and diagnostic applications.
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9.COMPOUNDS FOR TARGETING ENDOTHELIAL CELLS, COMPOSITIONS CONTAINING THE SAME AND METHODS FOR THEIR USE 审中-公开
标题翻译: 用于靶向内皮细胞的化合物,包含其的组合物及其使用方法公开(公告)号:US20110262366A1
公开(公告)日:2011-10-27
申请号:US12969327
申请日:2010-12-15
申请人: Mathew A. Von Wronski , Edmund R. Marinelli , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Michael F. Tweedle , Karen E. Linder , Palaniappa Nanjappan , Natarajan Raju , Feng Yan , Michel Schneider
发明人: Mathew A. Von Wronski , Edmund R. Marinelli , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Michael F. Tweedle , Karen E. Linder , Palaniappa Nanjappan , Natarajan Raju , Feng Yan , Michel Schneider
IPC分类号: A61K49/22 , C07K7/08 , C07K14/00 , C12N9/96 , A61P43/00 , C07K1/107 , A61K38/08 , A61K9/14 , A61K38/10 , A61K38/16 , C07K7/06 , C07K19/00
CPC分类号: A61K51/088 , A61K47/64 , A61K47/6925 , A61K49/006 , A61K49/0091 , A61K49/223 , A61K49/225 , A61K49/227 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07K7/06
摘要: The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.
摘要翻译: 本发明提供用于靶向表达NP-1受体的内皮细胞,肿瘤细胞或其他细胞的化合物,其含有该组合物的组合物及其使用方法。 另外,本发明包括可用于可视化,治疗或放射治疗的诊断,治疗和放射治疗组合物。
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10.Compounds for targeting endothelial cells, compositions containing the same and methods for their use 有权
标题翻译: 用于靶向内皮细胞的化合物,含有其的组合物及其使用方法公开(公告)号:US07884183B2
公开(公告)日:2011-02-08
申请号:US11381908
申请日:2006-05-05
申请人: Mathew A. Von Wronski , Edmund R. Marinelli , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Michael F. Tweedle , Karen E. Linder , Palaniappa Nanjappan , Natarajan Raju , Feng Yan , Michel Schneider
发明人: Mathew A. Von Wronski , Edmund R. Marinelli , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Michael F. Tweedle , Karen E. Linder , Palaniappa Nanjappan , Natarajan Raju , Feng Yan , Michel Schneider
CPC分类号: A61K51/088 , A61K47/64 , A61K47/6925 , A61K49/006 , A61K49/0091 , A61K49/223 , A61K49/225 , A61K49/227 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07K7/06
摘要: The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.
摘要翻译: 本发明提供用于靶向表达NP-1受体的内皮细胞,肿瘤细胞或其他细胞的化合物,其含有该组合物的组合物及其使用方法。 另外,本发明包括可用于可视化,治疗或放射治疗的诊断,治疗和放射治疗组合物。
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