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1.发明申请Peptide Mixture From Peptides Having A Molecular Weight Of from 1000 To 5000 Dalton 审中-公开具有分子量为1000至5000道尔顿的肽的肽混合物公开(公告)号：US20080096794A1
公开(公告)日：2008-04-24
申请号：US11660595
申请日：2005-08-12
申请人： Gunther Boehm , Christopher Beermann , Bernd Stahl , Gilda Georgi , Joachim Schmitt , Nadine Bock , Sorge Kelm
发明人： Gunther Boehm , Christopher Beermann , Bernd Stahl , Gilda Georgi , Joachim Schmitt , Nadine Bock , Sorge Kelm
CPC分类号： A23J3/346 , A23J3/344 , A23L33/18 , A23L33/40 , A61K35/20 , A61K36/06 , A61K36/31 , A61K36/48 , A61K36/88 , A61K38/168 , A61K38/1709 , A61K2300/00
摘要： The invention relates to the use of a peptide mixture comprising peptides with a molecular weight from 1000 to 5000 Daltons for the prevention and/or treatment of tumour diseases, of diseases which are associated with a development disorder of the immune system, of diseases of the immune system, of autoimmune reactions, of allergies and of inflammation in man, a protein component which contains such a peptide mixture and a formula food containing this peptide mixture. The peptides are preferably obtained from non-human proteins suitable for nutritional purposes, in particular by the enzymatic or hydrolytic cleavage of these proteins.
摘要翻译： 本发明涉及包含分子量为1000至5000道尔顿的肽的肽混合物在预防和/或治疗与免疫系统发育障碍相关的疾病的肿瘤疾病中的用途， 免疫系统，自身免疫反应，过敏和人类炎症，含有这种肽混合物的蛋白质组分和含有该肽混合物的配方食品。 肽优选地从适合于营养目的的非人蛋白质获得，特别是通过这些蛋白质的酶促或水解切割。
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公开(公告)号：US20080125346A1
公开(公告)日：2008-05-29
申请号：US11573939
申请日：2005-08-22
申请人： Christopher Beermann , Gunther Boehm , Bernd Stahl
发明人： Christopher Beermann , Gunther Boehm , Bernd Stahl
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： The present invention relates to a nutritional composition containing protein, fat and carbohydrate; and a. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates (NpxN); and b. a non-proteinaceous negatively charged, glycan or glycoconjugate component with a molecular weight between 200 and 20.000 dalton. The present nutritional composition is particularly suited for feeding infants as it mimics the protective effects of human milk, in particular against allergies and infections.
摘要翻译： 本发明涉及含有蛋白质，脂肪和碳水化合物的营养组合物; 和a。 选自核酸，核酸衍生物，核苷酸，多磷酸核苷，多核苷酸，核苷，核糖，脱氧核糖和二核苷酸多磷酸的核苷酸成分（Np×N）。 和b。 分子量在200至20.000道尔顿之间的非蛋白质带负电的聚糖或糖缀合物组分。 目前的营养组合物特别适用于喂养婴儿，因为它模仿人乳的保护作用，特别是针对过敏和感染。
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公开(公告)号：US08729123B2
公开(公告)日：2014-05-20
申请号：US13251399
申请日：2011-10-03
CPC分类号： A61K31/202 , A23L33/12 , A23L33/22 , A23L33/40 , A23V2002/00 , A23V2250/187 , A23V2250/1868 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/0644 , A23V2250/1642
摘要： The invention relates to the use of long chain polyunsaturated fatty acids for the manufacture of a nutritional composition for feeding infants of a mother who suffered from a metabolic disorder during pregnancy and to a corresponding composition. Said composition comprises a n-3 polyunsaturated fatty acid fraction containing at least 0.1 wt % docosahexaenoic acid (DHA) based on total weight of the lipid, at least 0.01 wt % n-3 docosapentaenoic acid (DPAn-3) based on total weight of the lipid, and at least 0.01 wt. % eicosapentaenoic acid (EPA) based on total weight of the lipid, wherein the sum of DHA, DPAn-3 and EPA is below 1 wt. % of total lipid.
摘要翻译： 本发明涉及长链多不饱和脂肪酸用于制造用于喂养怀孕期间代谢紊乱的母亲的婴儿的营养组合物和相应组合物的用途。 所述组合物包含n-3多不饱和脂肪酸级分，其含有基于脂质总重量的至少0.1重量％二十二碳六烯酸（DHA），至少0.01重量％的n-3二十二碳五烯酸（DPAn-3），基于 脂质和至少0.01重量％ 基于脂质总重量的二十碳五烯酸（EPA），其中DHA，DPAn-3和EPA的总和低于1wt。 总脂质的百分比。
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公开(公告)号：US20080269330A1
公开(公告)日：2008-10-30
申请号：US11666990
申请日：2005-11-11
IPC分类号： A61K31/202 , A61P3/02
CPC分类号： A61K31/202 , A23L33/12 , A23L33/22 , A23L33/40 , A23V2002/00 , A23V2250/187 , A23V2250/1868 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/0644 , A23V2250/1642
摘要： The invention relates to the use of long chain polyunsaturated fatty acids for the manufacture of a nutritional composition for feeding infants of a mother who suffered from a metabolic disorder during pregnancy and to a corresponding composition. Said composition comprises a n-3 polyunsaturated fatty acid fraction containing at least 0.1 wt docosahexaenoic acid (DHA) based on total weight of the lipid, at least 0.01 wt % n-3 docosapentaenoic acid (DPAn-3) based on total weight of the lipid, and at least 0.01 wt. % eicosapentaenoic acid (EPA) based on total weight of the lipid, wherein the sum of DHA, DPAn-3 and EPA is below 1 wt. % of total lipid.
摘要翻译： 本发明涉及长链多不饱和脂肪酸用于制造用于喂养怀孕期间代谢紊乱的母亲的婴儿的营养组合物和相应组合物的用途。 所述组合物包含n-3多不饱和脂肪酸级分，其含有至少0.1重量％的二十二碳六烯酸（DHA），基于脂质的总重量，至少0.01重量％的n-3二十二碳烯酸（DPAn-3），基于 脂质，和至少0.01重量％ 基于脂质总重量的二十碳五烯酸（EPA），其中DHA，DPAn-3和EPA的总和低于1wt。 总脂质的百分比。
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公开(公告)号：US20050075310A1
公开(公告)日：2005-04-07
申请号：US10497173
申请日：2003-05-27
申请人： Christopher Beermann , Lars Bode , Gunther Boehm
发明人： Christopher Beermann , Lars Bode , Gunther Boehm
IPC分类号： A23L1/29 , A23L1/30 , A61K31/7004 , A61K31/7028 , A61P3/02 , C07H15/10 , A61K31/739 , C08B37/00
CPC分类号： C07H15/10 , A23L33/105 , A23L33/40 , A61K31/7028 , A61K2300/00
摘要： The invention relates to a ganglioside mixture, consisting of gangliosides, of the following general formula: (sugar)-OCH2—CH(—NH—CO—R1)—CH(OH)—CH=CH-R2, wherein (sugar) represents a sugar radical, the group —CO—R1 represents an acyl-fatty acid which is bonded to the radical of the molecule in the form of an amide, R1 represents a straight saturated alkyl radical having at least 10 C-atoms and R2 represents a straight, saturated alkyl radical having at least 10 C-atoms or a straight alkenyl radical having at least 10 C-atoms and one, two or three double bond(s). Said mixture is characterised in that at least 10 wt. % of the gangliosides of the general formula I are of the group —CO—R1 and the acyl-fatty acids are a C20:0 fatty acid. Said mixtures exhibit an improved biological activity.
摘要翻译： 本发明涉及神经节苷脂混合物，由神经节苷脂组成，具有以下通式：（糖）-OCH 2 -CH（-NH-CO-R 1）-CH（OH）-CH = CH-R 2 ，其中（糖）表示糖基，基团-CO-R 1表示与酰基形式的分子基团结合的酰基脂肪酸，R 1表示直链饱和烷基 具有至少10个C原子的基团和R 2表示具有至少10个C原子的直链饱和烷基或具有至少10个C原子和一个，两个或三个双键的直链烯基， 。 所述混合物的特征在于，至少10wt。 通式I的神经节苷脂的％为-CO-R 1基团，酰基脂肪酸为C20：0脂肪酸。 所述混合物表现出改善的生物活性。
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公开(公告)号：US20120195975A1
公开(公告)日：2012-08-02
申请号：US13360508
申请日：2012-01-27
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： A nutritional or pharmaceutical composition comprising fat, protein, carbohydrate, whey and casein is provided. The composition has a weight ratio of casein to whey between 1:1 to 1:2.4 and comprises: a) at least 3 grams arginine per 100 grams protein; b) at least 10 wt. % linoleic acid based on total fatty acids; c) at least 1 wt. % alpha linolenic acid based on total fatty acids; d) at least one long chain-polyunsaturated fatty acid in an amount exceeding 0.1 wt. % based on total fatty acids selected from docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid; e) 5 to 25 wt. % of at least one polyunsaturated fatty acid based on total fatty acids; and f) 2 to 12 grams indigestible oligosaccharides having a degree of polymerisation of 2 to 100 per 100 gram dry weight of the composition. Methods of treatment by administering the composition are also provided.
摘要翻译： 提供了包含脂肪，蛋白质，碳水化合物，乳清和酪蛋白的营养或药物组合物。 该组合物的酪蛋白与乳清的重量比在1:1至1:2.4之间，包括：a）每100克蛋白质至少3克精氨酸; b）至少10wt。 ％亚油酸基于总脂肪酸; c）至少1wt。 基于总脂肪酸的％α亚麻酸; d）至少一种超过0.1重量％的长链多不饱和脂肪酸。 基于选自二十二碳六烯酸，花生四烯酸和二十碳五烯酸的总脂肪酸的％; e）5至25wt。 至少一种基于总脂肪酸的多不饱和脂肪酸的％; 和f）2至12克不可消化的低聚糖，其聚合度为每100克组合物干重2至100。 还提供了施用该组合物的治疗方法。
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公开(公告)号：US09084433B2
公开(公告)日：2015-07-21
申请号：US13594147
申请日：2012-08-24
申请人： Eric Alexander Franciscus Van Tol , Linette Eustachia Maria Willemsen , Marleen Antoinette Koetsier , Christopher Beermann , Bernd Stahl
发明人： Eric Alexander Franciscus Van Tol , Linette Eustachia Maria Willemsen , Marleen Antoinette Koetsier , Christopher Beermann , Bernd Stahl
CPC分类号： A23L29/04 , A23L29/30 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K31/202 , A61K31/702 , A23V2200/32 , A23V2200/304 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/28 , A23V2250/5062
摘要： The invention concerns a method for stimulating barrier integrity in a mammal by administering to a mammal a composition comprising: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (ARA), and at least two distinct oligosaccharides.
摘要翻译： 本发明涉及通过向哺乳动物施用包含二十碳五烯酸（EPA），二十二碳六烯酸（DHA）和花生四烯酸（ARA）以及至少两种不同的低聚糖的组合物来刺激哺乳动物的屏障完整性的方法。
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公开(公告)号：US08580316B2
公开(公告)日：2013-11-12
申请号：US13360508
申请日：2012-01-27
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： A nutritional or pharmaceutical composition comprising fat, protein, carbohydrate, whey and casein is provided. The composition has a weight ratio of casein to whey between 1:1 to 1:2.4 and comprises: a) at least 3 grams arginine per 100 grams protein; b) at least 10 wt. % linoleic acid based on total fatty acids; c) at least 1 wt. % alpha linolenic acid based on total fatty acids; d) at least one long chain-polyunsaturated fatty acid in an amount exceeding 0.1 wt. % based on total fatty acids selected from docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid; e) 5 to 25 wt. % of at least one polyunsaturated fatty acid based on total fatty acids; and 2 to 12 grams indigestible oligosaccharides having a degree of polymerisation of 2 to 100 per 100 gram dry weight of the composition. Methods of treatment by administering the composition are also provided.
摘要翻译： 提供了包含脂肪，蛋白质，碳水化合物，乳清和酪蛋白的营养或药物组合物。 该组合物的酪蛋白与乳清的重量比在1:1至1:2.4之间，包括：a）每100克蛋白质至少3克精氨酸; b）至少10wt。 ％亚油酸基于总脂肪酸; c）至少1wt。 基于总脂肪酸的％α亚麻酸; d）至少一种超过0.1重量％的长链多不饱和脂肪酸。 基于选自二十二碳六烯酸，花生四烯酸和二十碳五烯酸的总脂肪酸的％; e）5至25wt。 至少一种基于总脂肪酸的多不饱和脂肪酸的％; 和2至12克不可消化的寡糖，其组合物的每100克干重具有聚合度为2至100。 还提供了施用组合物的治疗方法。
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公开(公告)号：US08114441B2
公开(公告)日：2012-02-14
申请号：US11660594
申请日：2005-08-19
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： A nutritional or pharmaceutical composition containing a fat component, a protein component and a carbohydrate component and comprising whey and casein. The composition has a weight ratio of casein to whey is 1:1 to 1:2.4 and that the composition contains: a) at least 3 grams arginine per 100 grams protein; b) at least 10 wt. % linoleic acid based on total fatty acids; c) at least 1 wt. % alpha linolenic acid based on total fatty acids; d) at least one long chain-polyunsaturated fatty acid in an amount exceeding 0.1 wt. % based on total fatty acids. The long chain polyunsaturated fatty acid being docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid; e) 5 to 25 wt. % of at least one polyunsaturated fatty acid based on total fatty acids; and f) 2 to 12 grams indigestible oligosaccharides having a degree of polymerization of 2 to 100 per 100 gram dry weight of the composition. The composition reduces—among others—the risks attached to feeding whey dominant infant formula.
摘要翻译： 一种含有脂肪组分，蛋白质组分和碳水化合物组分并包含乳清和酪蛋白的营养或药物组合物。 该组合物的酪蛋白与乳清的重量比为1:1至1:2.4，组合物含有：a）每100克蛋白质至少3克精氨酸; b）至少10wt。 ％亚油酸基于总脂肪酸; c）至少1wt。 基于总脂肪酸的％α亚麻酸; d）至少一种超过0.1重量％的长链多不饱和脂肪酸。 基于总脂肪酸的％。 长链多不饱和脂肪酸是二十二碳六烯酸，花生四烯酸和二十碳五烯酸; e）5至25wt。 至少一种基于总脂肪酸的多不饱和脂肪酸的％; 和f）2至12克不可消化的低聚糖，其聚合度为组合物每100克干重2至100。 组合物减少 - 其中包括喂食乳清主要婴儿配方奶粉的风险。
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公开(公告)号：US08053471B2
公开(公告)日：2011-11-08
申请号：US11666990
申请日：2005-11-11
CPC分类号： A61K31/202 , A23L33/12 , A23L33/22 , A23L33/40 , A23V2002/00 , A23V2250/187 , A23V2250/1868 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/0644 , A23V2250/1642
摘要： The invention relates to the use of long chain polyunsaturated fatty acids for the manufacture of a nutritional composition for feeding infants of a mother who suffered from a metabolic disorder during pregnancy and to a corresponding composition. Said composition comprises a n-3 polyunsaturated fatty acid fraction containing at least 0.1 wt docosahexaenoic acid (DHA) based on total weight of the lipid, at least 0.01 wt % n-3 docosapentaenoic acid (DPAn-3) based on total weight of the lipid, and at least 0.01 wt. % eicosapentaenoic acid (EPA) based on total weight of the lipid, wherein the sum of DHA, DPAn-3 and EPA is below 1 wt. % of total lipid.
摘要翻译： 本发明涉及长链多不饱和脂肪酸用于制造用于喂养怀孕期间代谢紊乱的母亲的婴儿的营养组合物和相应组合物的用途。 所述组合物包含n-3多不饱和脂肪酸级分，其含有至少0.1重量％的二十二碳六烯酸（DHA），基于脂质的总重量，至少0.01重量％的n-3二十二碳烯酸（DPAn-3），基于 脂质，和至少0.01重量％ 基于脂质总重量的二十碳五烯酸（EPA），其中DHA，DPAn-3和EPA的总和低于1wt。 总脂质的百分比。
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