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公开(公告)号:US09096518B2
公开(公告)日:2015-08-04
申请号:US12803169
申请日:2010-06-21
IPC分类号: C07D217/16 , A61K31/47 , C07D209/44 , C07D217/04 , C07D217/06 , C07D217/08 , C07D223/16 , C07D225/06 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D491/04
CPC分类号: C07D223/16 , C07D209/44 , C07D217/04 , C07D217/06 , C07D217/08 , C07D225/06 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D491/04
摘要: This invention provides compounds of formula (I) wherein R1, R2, G, m, n, p and q have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
摘要翻译: 本发明提供式(I)化合物,其中R 1,R 2,G,m,n,p和q具有如说明书中所述的值,可用作HDAC6的抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗增殖性,炎症性,感染性,神经性或心血管疾病或病症的方法。
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公开(公告)号:US20110039827A1
公开(公告)日:2011-02-17
申请号:US12803169
申请日:2010-06-21
IPC分类号: A61K31/4725 , C07D401/06 , C07D217/16 , C07D209/44 , C07D403/04 , C07D223/16 , A61K31/472 , A61K31/4035 , A61K31/55 , A61P35/00 , A61P35/02
CPC分类号: C07D223/16 , C07D209/44 , C07D217/04 , C07D217/06 , C07D217/08 , C07D225/06 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D491/04
摘要: This invention provides compounds of formula (I): wherein R1, R2, G, m, n, p and q have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
摘要翻译: 本发明提供式(I)化合物:其中R 1,R 2,G,m,n,p和q具有如说明书中所述的值,可用作HDAC6的抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗增殖性,炎症性,感染性,神经性或心血管疾病或病症的方法。
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公开(公告)号:US20110213003A1
公开(公告)日:2011-09-01
申请号:US13034947
申请日:2011-02-25
申请人: Christopher Blackburn , Kenneth M. Gigstad , He Xu
发明人: Christopher Blackburn , Kenneth M. Gigstad , He Xu
IPC分类号: A61K31/426 , C07D277/56 , C07D207/34 , A61K31/40 , C07D413/12 , A61K31/422 , C07D261/18 , C07D417/12 , A61K31/427 , C07D403/12 , A61K31/4178 , C07D333/22 , A61K31/381 , C07D409/12 , A61P35/00
CPC分类号: C07D333/38 , C07D207/34 , C07D261/18 , C07D277/56 , C07D333/22 , C07D333/70 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要: This invention provides compounds of formula (I): wherein X1, X2, X3, R2, R4b, R1, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
摘要翻译: 本发明提供式(I)化合物:其中X1,X2,X3,R2,R4b,R1和G具有如本说明书中所述的值,可用作HDAC6的抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗增殖性,炎症性,感染性,神经性或心血管疾病或病症的方法。
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公开(公告)号:US20120053201A1
公开(公告)日:2012-03-01
申请号:US13217401
申请日:2011-08-25
申请人: Christopher Blackburn , Kenneth M. Gigstad , He Xu
发明人: Christopher Blackburn , Kenneth M. Gigstad , He Xu
IPC分类号: A61K31/4375 , A61P35/00 , A61P35/02 , C07D471/04
CPC分类号: C07D471/04 , A61K31/4375 , C07D215/54
摘要: This invention provides compounds of formula (I): wherein R1a, R1b, R1c, R1d, R2a, R2b, X1, X2, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
摘要翻译: 本发明提供式(I)化合物:其中R1a,R1b,R1c,R1d,R2a,R2b,X1,X2和G具有如本说明书中所述的值,可用作HDAC6的抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗增殖性,炎症性,感染性,神经性或心血管疾病或病症的方法。
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公开(公告)号:US20120015943A1
公开(公告)日:2012-01-19
申请号:US13184600
申请日:2011-07-18
申请人: Christopher Blackburn , Emily F. Calderwood , Kenneth M. Gigstad , Alexandra E. Gould , Sean J. Harrison , He Xu
发明人: Christopher Blackburn , Emily F. Calderwood , Kenneth M. Gigstad , Alexandra E. Gould , Sean J. Harrison , He Xu
IPC分类号: A61K31/166 , A61K31/4545 , C07C259/10 , C07D239/42 , A61K31/505 , C07D213/75 , A61K31/4418 , C07D213/68 , A61K31/4409 , C07D211/62 , A61K31/4465 , C07D207/34 , A61K31/40 , C07D487/08 , A61K31/407 , A61P35/00 , C07D413/06 , A61K31/5377 , C07D401/12
CPC分类号: C07D239/26 , A61K31/166 , A61K31/40 , A61K31/407 , A61K31/4409 , A61K31/4418 , A61K31/4465 , A61K31/4545 , A61K31/505 , A61K31/5377 , C07C259/10 , C07C259/18 , C07C271/58 , C07C275/28 , C07C311/20 , C07C2601/14 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D207/34 , C07D209/42 , C07D211/62 , C07D211/64 , C07D213/40 , C07D213/56 , C07D213/68 , C07D213/75 , C07D213/81 , C07D231/12 , C07D231/14 , C07D261/18 , C07D277/62 , C07D307/68 , C07D307/85 , C07D333/70 , C07D409/06 , C07D471/04
摘要: This invention provides compounds of formula (I): wherein R1, R1b, R2a, R2b, R2c, and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
摘要翻译: 本发明提供式(I)化合物:其中R1,R1b,R2a,R2b,R2c和R2d具有如本说明书中所述的值,可用作HDAC6的抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗增殖性,炎症性,感染性,神经性或心血管疾病或病症的方法。
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公开(公告)号:US08471026B2
公开(公告)日:2013-06-25
申请号:US13217401
申请日:2011-08-25
申请人: Christopher Blackburn , Kenneth M. Gigstad , He Xu
发明人: Christopher Blackburn , Kenneth M. Gigstad , He Xu
IPC分类号: C07D471/02 , A61K31/44
CPC分类号: C07D471/04 , A61K31/4375 , C07D215/54
摘要: This invention provides compounds of formula (I): wherein R1a, R1b, R1c, R1d, R2a, R2b, X1, X2, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
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公开(公告)号:US20110212969A1
公开(公告)日:2011-09-01
申请号:US13034974
申请日:2011-02-25
IPC分类号: A61K31/166 , C07C259/10 , C07D307/85 , A61K31/343 , C07D491/048 , A61K31/407 , C07D307/68 , A61K31/341 , C07D209/42 , A61K31/404 , C07D333/70 , A61K31/381 , C07D239/28 , A61K31/505 , C07D471/04 , A61K31/437 , C07D237/28 , A61K31/502 , C07D241/24 , A61K31/4965 , C07D241/44 , A61K31/498 , A61P35/00
CPC分类号: C07C259/08 , A61K31/166 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/407 , A61K31/437 , A61K31/4965 , A61K31/498 , A61K31/502 , A61K31/505 , C07C259/10 , C07C275/26 , C07C275/28 , C07C275/34 , C07C311/06 , C07C311/19 , C07C2601/04 , C07C2601/06 , C07D207/34 , C07D209/42 , C07D211/62 , C07D231/14 , C07D233/84 , C07D237/28 , C07D239/28 , C07D241/44 , C07D277/56 , C07D277/64 , C07D285/14 , C07D307/84 , C07D307/85 , C07D311/14 , C07D333/68 , C07D333/70 , C07D417/04 , C07D491/04 , C07D491/048
摘要: This invention provides compounds of formula (I): wherein ring A, X1, X2, X3, R2, R4b, R10, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
摘要翻译: 本发明提供式(I)化合物:其中环A,X 1,X 2,X 3,R 2,R 4 b,R 10和G具有如说明书中所述的值,可用作HDAC6的抑制剂。 本发明还提供包含本发明化合物的药物组合物,以及使用该组合物治疗增殖性,炎症性,感染性,神经性或心血管疾病或病症的方法。
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公开(公告)号:US20110046157A1
公开(公告)日:2011-02-24
申请号:US12803170
申请日:2010-06-21
申请人: Christopher Blackburn , Kenneth M. Gigstad , He Xu
发明人: Christopher Blackburn , Kenneth M. Gigstad , He Xu
IPC分类号: A61K31/497 , C07D495/04 , A61K31/4365 , A61K31/513 , A61K31/506 , A61K31/407 , A61P35/00 , A61P35/02
CPC分类号: C07D495/04 , A61K31/38
摘要: This invention provides compounds of formula (I): wherein R1, R2, G, n, p and q have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
摘要翻译: 本发明提供式(I)化合物:其中R 1,R 2,G,n,p和q具有如说明书中所述的值,可用作HDAC6的抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗增殖性,炎症性,感染性,神经性或心血管疾病或病症的方法。
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公开(公告)号:US20150105418A1
公开(公告)日:2015-04-16
申请号:US14573615
申请日:2014-12-17
申请人: Christopher Blackburn , Kenneth M. Gigstad , He Xu
发明人: Christopher Blackburn , Kenneth M. Gigstad , He Xu
IPC分类号: C07D471/04
CPC分类号: C07D471/04 , A61K31/4375 , C07D215/54
摘要: This invention provides compounds of formula (I): wherein R1a, R1b, R1c, R1d, R2a, R2b, X1, X2, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
摘要翻译: 本发明提供式(I)化合物:其中R1a,R1b,R1c,R1d,R2a,R2b,X1,X2和G具有如本说明书中所述的值,可用作HDAC6的抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗增殖性,炎症性,感染性,神经性或心血管疾病或病症的方法。
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公开(公告)号:US20110251184A1
公开(公告)日:2011-10-13
申请号:US13084181
申请日:2011-04-11
申请人: Christopher Blackburn , Janice Chin , Kenneth M. Gigstad , He Xu
发明人: Christopher Blackburn , Janice Chin , Kenneth M. Gigstad , He Xu
IPC分类号: A61K31/551 , A61K31/4985 , A61P35/00 , C07D487/04
CPC分类号: C07D487/04 , C07D519/00
摘要: This invention provides compounds of formula (I): wherein X1, X2, R1a, R1b, R1c, R1d, n, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
摘要翻译: 本发明提供式(I)化合物:其中X1,X2,R1a,R1b,R1c,R1d,n和G具有如本说明书中所述的值,可用作HDAC6的抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗增殖性,炎症性,感染性,神经性或心血管疾病或病症的方法。
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