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公开(公告)号:US20070265248A1
公开(公告)日:2007-11-15
申请号:US11116759
申请日:2005-04-27
申请人: Christopher Fotsch , Premilla Arasasingham , Yunxin Bo , Ning Chen , Martin Goldberg , Nianhe Han , Feng-Yin Hsieh , Michael Kelly , Qingyian Liu , Mark Norman , Duncan Smith , Markian Stec , Nuria Tamayo , Ning Xi , Shimin Xu , Elizabeth Doherty
发明人: Christopher Fotsch , Premilla Arasasingham , Yunxin Bo , Ning Chen , Martin Goldberg , Nianhe Han , Feng-Yin Hsieh , Michael Kelly , Qingyian Liu , Mark Norman , Duncan Smith , Markian Stec , Nuria Tamayo , Ning Xi , Shimin Xu , Elizabeth Doherty
IPC分类号: A61K31/4965 , A61K31/497 , A61K31/551 , A61P3/10 , C07D243/08 , C07D401/00 , C07D403/12 , C07D407/00
CPC分类号: C07D207/08 , A61K38/00 , C07D205/04 , C07D207/09 , C07D209/14 , C07D209/42 , C07D211/26 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/06 , C07D217/14 , C07D217/26 , C07D233/64 , C07D295/185 , C07D317/60 , C07D317/68 , C07D319/18 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/02 , C07K5/06026 , C07K5/06139 , C07K5/06147 , C07K5/06191
摘要: Selected substituted piperazine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选的取代哌嗪化合物对于预防和治疗诸如肥胖症等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗涉及黑皮质素受体活化的疾病和其它疾病或病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US07115607B2
公开(公告)日:2006-10-03
申请号:US10202823
申请日:2002-07-24
申请人: Christopher H. Fotsch , Premilla Arasasingham , Yunxin Bo , Ning Chen , Martin H. Goldberg , Nianhe Han , Feng-Yin Hsieh , Michael G. Kelly , Qingyian Liu , Mark H. Norman , Duncan M. Smith , Markian Stec , Nuria Tamayo , Ning Xi , Shimin Xu
发明人: Christopher H. Fotsch , Premilla Arasasingham , Yunxin Bo , Ning Chen , Martin H. Goldberg , Nianhe Han , Feng-Yin Hsieh , Michael G. Kelly , Qingyian Liu , Mark H. Norman , Duncan M. Smith , Markian Stec , Nuria Tamayo , Ning Xi , Shimin Xu
IPC分类号: A61K31/496 , C07D401/12 , C07D403/12
CPC分类号: C07D207/08 , A61K38/00 , C07D205/04 , C07D207/09 , C07D209/14 , C07D209/42 , C07D211/26 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/06 , C07D217/14 , C07D217/26 , C07D233/64 , C07D295/185 , C07D317/60 , C07D317/68 , C07D319/18 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/02 , C07K5/06026 , C07K5/06139 , C07K5/06147 , C07K5/06191
摘要: Selected substituted piperazine compounds of Formula I are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 式I的选择性取代哌嗪化合物对预防和治疗诸如肥胖症等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗涉及黑皮质素受体活化的疾病和其它疾病或病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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