-
公开(公告)号:US20110230446A1
公开(公告)日:2011-09-22
申请号:US13115462
申请日:2011-05-25
申请人: Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Chirstophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人: Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Chirstophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号: A61K31/277 , A61K31/495 , A61K31/4418 , A61K31/426 , A61K31/4174 , A61K31/663 , A61P19/08 , A61P19/10 , A61P1/02 , A61P19/02 , A61P35/00 , A61P19/00
CPC分类号: C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译: 本发明涉及一类新的化合物,它们是半胱氨酸蛋白酶抑制剂,包括但不限于组织蛋白酶K,L,S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病,例如 骨质疏松症
-
公开(公告)号:US20080188529A1
公开(公告)日:2008-08-07
申请号:US12082104
申请日:2008-04-08
申请人: Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人: Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号: A61K31/4418 , C07C233/40 , A61K31/165 , C07D213/57
CPC分类号: C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译: 本发明涉及一类新的化合物,它们是半胱氨酸蛋白酶抑制剂,包括但不限于组织蛋白酶K,L,S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病,例如 骨质疏松症
-
公开(公告)号:US08318748B2
公开(公告)日:2012-11-27
申请号:US13115462
申请日:2011-05-25
申请人: Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人: Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号: A61K31/4965 , A61K31/66 , A61K31/44 , A61K31/445 , A61K31/425 , A61K31/415
CPC分类号: C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译: 本发明涉及一类新的化合物,它们是半胱氨酸蛋白酶抑制剂,包括但不限于组织蛋白酶K,L,S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病,例如 骨质疏松症
-
公开(公告)号:US07973037B2
公开(公告)日:2011-07-05
申请号:US12082104
申请日:2008-04-08
申请人: Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人: Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号: A61K31/535 , A61K31/497 , A61K31/435 , A61K31/385 , C07D265/30 , C07D241/04 , C07D211/08 , C07D333/02 , C07D255/03
CPC分类号: C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译: 本发明涉及一类新的化合物,它们是半胱氨酸蛋白酶抑制剂,包括但不限于组织蛋白酶K,L,S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病,例如 骨质疏松症
-
公开(公告)号:US07375134B2
公开(公告)日:2008-05-20
申请号:US10505796
申请日:2003-02-28
申请人: Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien
发明人: Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien
IPC分类号: A01N37/34
CPC分类号: C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
-
6.Phosphonic acid biaryl derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) 失效
标题翻译: 作为蛋白酪氨酸磷酸酶1B(PTP-1B)的抑制剂的膦酸联芳衍生物公开(公告)号:US06486141B2
公开(公告)日:2002-11-26
申请号:US09745199
申请日:2000-12-21
申请人: Cheuk Kun Lau , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Chun Sing Li , Patrick Roy , Michel Therien , Zhaoyin Wang
发明人: Cheuk Kun Lau , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Chun Sing Li , Patrick Roy , Michel Therien , Zhaoyin Wang
IPC分类号: A61K31663
CPC分类号: C07F9/65583 , C07F9/65188
摘要: The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related conditions.
摘要翻译: 本发明包括作为PTP-1B酶抑制剂的由式I表示的新一类化合物。本发明还包括治疗或预防PTP-1B介导的疾病的药物组合物和方法,包括糖尿病,肥胖症和糖尿病相关病症 。
-
7.Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) 失效
标题翻译: 作为蛋白酪氨酸磷酸酶1B(PTP-1B)抑制剂的膦酸衍生物公开(公告)号:US06486142B2
公开(公告)日:2002-11-26
申请号:US09745211
申请日:2000-12-21
申请人: Yves Leblanc , Claude Dufresne , Jacques Yves Gauthier , Cheuk Kun Lau , Chun Sing Li , Patrick Roy , Michel Therien , John Scheigetz , Zhaoyin Wang
发明人: Yves Leblanc , Claude Dufresne , Jacques Yves Gauthier , Cheuk Kun Lau , Chun Sing Li , Patrick Roy , Michel Therien , John Scheigetz , Zhaoyin Wang
IPC分类号: C07F938
CPC分类号: C07F9/6539 , C07F9/3882 , C07F9/4075 , C07F9/4087 , C07F9/65188 , C07F9/65318
摘要: The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and conditions related to diabetes.
摘要翻译: 本发明包括由式I表示的新型化合物,其是PTP-1B酶的抑制剂。本发明还包括治疗或预防PTP-1B介导的疾病的药物组合物和方法,包括糖尿病,肥胖症和与 糖尿病。
-
8.Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors 失效
标题翻译: 具有含硫取代基的芳基二氟甲基膦酸作为PTP-1B抑制剂公开(公告)号:US06498151B2
公开(公告)日:2002-12-24
申请号:US09813489
申请日:2001-03-21
申请人: Chun Sing Li , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Cheuk Kun Lau , Patrick Roy , Michel Therien , Zhaoyin Wang , Claude Dufresne , Rejean Fortin
发明人: Chun Sing Li , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Cheuk Kun Lau , Patrick Roy , Michel Therien , Zhaoyin Wang , Claude Dufresne , Rejean Fortin
IPC分类号: C07D23995
CPC分类号: C07F9/65583 , A61K31/66 , A61K45/06 , C07F9/3882 , C07F9/4056 , C07F9/5537 , C07F9/58 , C07F9/59 , C07F9/60 , C07F9/6506 , C07F9/65068 , C07F9/6512 , C07F9/65128 , C07F9/6518 , C07F9/6524 , C07F9/65312 , C07F9/65318 , C07F9/6539 , C07F9/65395 , C07F9/6552 , C07F9/65522 , A61K2300/00
摘要: The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
摘要翻译: 本发明包括由下式表示的新型化合物,其是PTP-1B酶的抑制剂。本发明还包括治疗或预防PTP-1B介导的疾病包括糖尿病的药物组合物和方法。
-
9.Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase 审中-公开
标题翻译: 杂芳族化合物作为硬脂酰辅酶A Delta-9去饱和酶的抑制剂公开(公告)号:US20090118296A1
公开(公告)日:2009-05-07
申请号:US11988192
申请日:2006-07-18
申请人: Cameron Black , Denis Deschenes , Marc Gagnon , Nicolas Lachance , Yves LeBlanc , Serge Leger , Chun Sing Li , Renata M. Oballa
发明人: Cameron Black , Denis Deschenes , Marc Gagnon , Nicolas Lachance , Yves LeBlanc , Serge Leger , Chun Sing Li , Renata M. Oballa
IPC分类号: A61K31/501 , C07D417/14 , A61P3/00
CPC分类号: C07D413/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07F9/65583
摘要: Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and fatty liver disease.
摘要翻译: 结构式(I)的杂芳族化合物是相对于其他已知的硬脂酰辅酶A去饱和酶的硬脂酰辅酶Aδ-9去饱和酶(SCD1)的选择性抑制剂。 本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症,包括心血管疾病; 动脉粥样硬化 脂质紊乱 肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 和脂肪肝病。
-
公开(公告)号:US07407959B2
公开(公告)日:2008-08-05
申请号:US11282536
申请日:2005-11-18
IPC分类号: A61K31/497 , A61K31/425 , C07D241/04 , C07D211/84 , C07D277/30
CPC分类号: C07C255/46 , C07C2601/02
摘要: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
-
-
-
-
-
-
-
-
-