摘要:
The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要:
The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要:
The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要:
The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitors of the complement alternative pathway, in particular of Factor B. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要:
The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要:
The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.
摘要:
A carbonization apparatus for coal with wide particle size distribution, a carbonization apparatus unit, and a carbonization method using the apparatus. The apparatus includes a char discharge outlet, a combustion heating chamber, a coal feeding inlet, a pyrolysis gas exhausting pipe, and two partition plates between which a pyrolysis gas channel is formed. Orifices are provided on the partition plates to form a gas flow path from the fuel bed to the pyrolysis gas channel. The pyrolysis gas channel in the carbonization apparatus permits the gaseous products generated from coal pyrolysis to flow out in a timely manner.
摘要:
In one embodiment, active links are added to, and removed from, a multichassis link bundle with one side of the multichassis link bundle terminated on multiple devices of a multichassis device. In one embodiment, adding active links includes selecting which particular device to which to add an active link to the multichassis link bundle based on a device priority of each of the multiple devices, with a device priority of a given device being based on a current number of active links associated with the given device.
摘要:
Throughput of a high-volume throughput-centric computer system is controlled by dynamically adjusting a concurrency level of a plurality of events being processed in a computer system to meet a predetermined target for utilization of one or more resources of a computer system. The predetermined target is less than 100% utilization of said one or more resources. The adjusted concurrency level is validated using one or more queuing models to check that said predetermined target is being met. Parameters are configured for adjusting the concurrency level. The parameters are configured so that said one or more resources are shared with one or more external programs. A statistical algorithm is established that minimizes total number of samples collected. The samples may be used to measure performance used to further dynamically adjust the concurrency level. A dynamic thread sleeping method is designed to handle systems that need only a very small number of threads to saturate bottleneck resources and hence are sensitive to concurrency level changes.
摘要:
Methods are provided for functionalizing nanoscale fibers and for making composite structures from these functionalized nanomaterials. The method includes contacting a network of nanoscale fibers with an oxidant to graft at least one epoxide group to at least a portion of the network of nanoscale fibers. A network of functionalized nanoscale fibers or buckypapers may include carbon nanotubes having a mean length of at least 1 mm and having an epoxide group grafted onto the nanotubes.