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公开(公告)号:US20100266714A1
公开(公告)日:2010-10-21
申请号:US12740105
申请日:2008-10-29
申请人: Christopher S Burgey , Diem Nguyen , Zhengwu Deng , Daniel V. Paone , Craig M. Potteiger , Joseph P. Vacca
发明人: Christopher S Burgey , Diem Nguyen , Zhengwu Deng , Daniel V. Paone , Craig M. Potteiger , Joseph P. Vacca
IPC分类号: A61K33/00 , C07D401/12 , A61K31/444 , A61P25/08 , A61P25/04 , C07C235/42 , A61K31/166 , C07D239/26 , A61K31/505 , C07D403/12 , A61K31/506 , C07D413/12 , A61K31/5377 , A61K31/5513
CPC分类号: C07C233/66 , C07C233/65 , C07C233/83 , C07C233/87 , C07D213/56 , C07D213/61 , C07D213/89 , C07D239/26 , C07D249/08 , C07D271/06 , C07D401/12 , C07D401/14 , C07D413/14
摘要: The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.
摘要翻译: 本发明涉及在治疗与疼痛有关的疾病状态,特别是外周疼痛,炎症性疼痛或可用P2X3受体亚基调节剂治疗的组织损伤疼痛中发挥关键作用的新型P2X3受体拮抗剂。