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1.发明授权
公开(公告)号：US6020343A
公开(公告)日：2000-02-01
申请号：US97543
申请日：1998-06-15
申请人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
发明人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
IPC分类号： C07C317/24 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/665
CPC分类号： C07D405/12 , C07C317/24 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07C2101/08
摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式I化合物。 本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。
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公开(公告)号：US06465509B2
公开(公告)日：2002-10-15
申请号：US09892941
申请日：2001-06-27
申请人： Chun-Sing Li , Cheuk Kun Lau , Michel Therien , Petpiboon Prasit
发明人： Chun-Sing Li , Cheuk Kun Lau , Michel Therien , Petpiboon Prasit
IPC分类号： A61K3135
CPC分类号： C07D309/38
摘要： The invention encompasses the novel compounds of Formula I, which are useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions comprising compounds of Formula I as well as methods of treating cyclooxygenase-2 mediated diseases comprising administering to a patient in need of such treatment a non-toxic therapeutically effective amount of a compound of Formula I.
摘要翻译： 本发明包括式I化合物，其可用于治疗环氧合酶-2介导的疾病。本发明还包括含有式I化合物的某些药物组合物以及治疗环加氧酶-2介导的疾病的方法，包括给予 需要这种治疗的患者是无毒的治疗有效量的式I化合物。
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3.发明授权公开(公告)号：US06169188A
公开(公告)日：2001-01-02
申请号：US09422151
申请日：1999-10-21
申请人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
发明人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
IPC分类号： C07D31744
CPC分类号： C07D405/12 , C07C317/24 , C07C2601/08 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括可用于治疗环加氧酶-2介导的疾病的新颖的式I化合物。本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。
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4.发明授权
公开(公告)号：US5981576A
公开(公告)日：1999-11-09
申请号：US97537
申请日：1998-06-15
申请人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
发明人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
IPC分类号： C07C317/24 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D307/02 , A61K31/34
CPC分类号： C07C317/24 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07C2101/08
摘要： The invention encompasses the novel compound of Formula A that is useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula A.
摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式A化合物。 本发明还包括用于治疗包含式A化合物的环氧合酶-2介导的疾病的某些药物组合物。
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5.发明授权公开(公告)号：US06211210B1
公开(公告)日：2001-04-03
申请号：US09561565
申请日：2000-04-28
IPC分类号： C07D28506
CPC分类号： C07D285/06
摘要： The invention encompasses compounds of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I化合物以及治疗COX-2介导的疾病的方法，其包括给予需要这种治疗无毒治疗有效量的式I化合物的患者。本发明还包括某些药物 用于治疗包含式I化合物的COX-2介导的疾病的组合物。
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6.发明授权Phosphonic acid biaryl derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) 失效作为蛋白酪氨酸磷酸酶1B（PTP-1B）的抑制剂的膦酸联芳衍生物公开(公告)号：US06486141B2
公开(公告)日：2002-11-26
申请号：US09745199
申请日：2000-12-21
申请人： Cheuk Kun Lau , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Chun Sing Li , Patrick Roy , Michel Therien , Zhaoyin Wang
发明人： Cheuk Kun Lau , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Chun Sing Li , Patrick Roy , Michel Therien , Zhaoyin Wang
IPC分类号： A61K31663
CPC分类号： C07F9/65583 , C07F9/65188
摘要： The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related conditions.
摘要翻译： 本发明包括作为PTP-1B酶抑制剂的由式I表示的新一类化合物。本发明还包括治疗或预防PTP-1B介导的疾病的药物组合物和方法，包括糖尿病，肥胖症和糖尿病相关病症 。
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7.发明授权Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) 失效作为蛋白酪氨酸磷酸酶1B（PTP-1B）抑制剂的膦酸衍生物公开(公告)号：US06486142B2
公开(公告)日：2002-11-26
申请号：US09745211
申请日：2000-12-21
申请人： Yves Leblanc , Claude Dufresne , Jacques Yves Gauthier , Cheuk Kun Lau , Chun Sing Li , Patrick Roy , Michel Therien , John Scheigetz , Zhaoyin Wang
发明人： Yves Leblanc , Claude Dufresne , Jacques Yves Gauthier , Cheuk Kun Lau , Chun Sing Li , Patrick Roy , Michel Therien , John Scheigetz , Zhaoyin Wang
IPC分类号： C07F938
CPC分类号： C07F9/6539 , C07F9/3882 , C07F9/4075 , C07F9/4087 , C07F9/65188 , C07F9/65318
摘要： The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and conditions related to diabetes.
摘要翻译： 本发明包括由式I表示的新型化合物，其是PTP-1B酶的抑制剂。本发明还包括治疗或预防PTP-1B介导的疾病的药物组合物和方法，包括糖尿病，肥胖症和与 糖尿病。
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8.发明授权Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors 失效具有含硫取代基的芳基二氟甲基膦酸作为PTP-1B抑制剂公开(公告)号：US06498151B2
公开(公告)日：2002-12-24
申请号：US09813489
申请日：2001-03-21
申请人： Chun Sing Li , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Cheuk Kun Lau , Patrick Roy , Michel Therien , Zhaoyin Wang , Claude Dufresne , Rejean Fortin
发明人： Chun Sing Li , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Cheuk Kun Lau , Patrick Roy , Michel Therien , Zhaoyin Wang , Claude Dufresne , Rejean Fortin
IPC分类号： C07D23995
CPC分类号： C07F9/65583 , A61K31/66 , A61K45/06 , C07F9/3882 , C07F9/4056 , C07F9/5537 , C07F9/58 , C07F9/59 , C07F9/60 , C07F9/6506 , C07F9/65068 , C07F9/6512 , C07F9/65128 , C07F9/6518 , C07F9/6524 , C07F9/65312 , C07F9/65318 , C07F9/6539 , C07F9/65395 , C07F9/6552 , C07F9/65522 , A61K2300/00
摘要： The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
摘要翻译： 本发明包括由下式表示的新型化合物，其是PTP-1B酶的抑制剂。本发明还包括治疗或预防PTP-1B介导的疾病包括糖尿病的药物组合物和方法。
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公开(公告)号：US06329421B1
公开(公告)日：2001-12-11
申请号：US08793931
申请日：1997-02-25
申请人： Petpiboon Prasit , Daniel Guay , Zhaoyin Wang , Serge Leger , Michel Therien
发明人： Petpiboon Prasit , Daniel Guay , Zhaoyin Wang , Serge Leger , Michel Therien
IPC分类号： A61K3134
CPC分类号： C07D307/79 , C07D209/10 , C07D333/18 , C07D495/04
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新化合物以及治疗环加氧酶-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用本发明还包括 用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。
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10.发明授权
公开(公告)号：US5389650A
公开(公告)日：1995-02-14
申请号：US951635
申请日：1992-09-25
IPC分类号： A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/495 , A61K31/505 , A61P11/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07D401/12 , C07D403/06 , C07D403/12
CPC分类号： C07D401/12 , C07D403/06 , C07D403/12
摘要： Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
摘要翻译： 具有式I的化合物：I是抑制白三烯生物合成。 这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。 它们也可用于治疗腹泻，高血压，心绞痛，血小板聚集，脑痉挛，早产，自然流产，痛经和偏头痛。
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