公开(公告)号：US09357206B2

公开(公告)日：2016-05-31

申请号：US13480432

申请日：2012-05-24

申请人： Clarence E. Thomas ,  David L. Page

发明人： Clarence E. Thomas ,  David L. Page

IPC分类号： H04N13/04 ,  G06T7/00 ,  H04N9/31

CPC分类号： H04N13/349 ,  G06T7/73 ,  G06T2207/30204 ,  H04N9/3147 ,  H04N9/3182 ,  H04N9/3194 ,  H04N13/302 ,  H04N13/327 ,  H04N13/363

摘要： Systems and methods for calibrating a 3D display system. In one embodiment, a system includes a display screen, 2D image projectors that project 2D projection images onto the screen and a camera that captures calibration images of the screen. A computer generates the 2D projection images, which include calibration patterns, and processes the captured calibration images. The computer uses the calibration images to calculate corrections based upon the calibration images. The computer can then generate corrected 2D projection images that are projected by the 2D image projectors onto the screen to produce a substantially visually correct 3D image with continuous viewing, true horizontal parallax, and a different view for each eye within a valid viewing zone. The corrections to the images may include corrections to the geometry (including distortion, alignment, etc.) color (including intensity and related parameters).

摘要翻译： 用于校准3D显示系统的系统和方法。 在一个实施例中，系统包括显示屏幕，将2D投影图像投影到屏幕上的2D图像投影仪和捕获屏幕的校准图像的相机。 计算机生成2D投影图像，其包括校准图案，并处理所捕获的校准图像。 计算机使用校准图像根据校准图像计算校正值。 然后，计算机可以生成由2D图像投影仪投影到屏幕上的校正的2D投影图像，以产生具有连续观看，真实水平视差以及在有效观看区域内的每只眼睛的不同视图的基本上视觉正确的3D图像。 对图像的校正可能包括校正几何（包括失真，对齐等）颜色（包括强度和相关参数）。

公开(公告)号：US20190007677A1

公开(公告)日：2019-01-03

申请号：US15965936

申请日：2018-04-29

申请人： Clarence E. Thomas ,  David L. Page

发明人： Clarence E. Thomas ,  David L. Page

IPC分类号： H04N13/363 ,  G02B27/22 ,  G02B26/12 ,  H04N13/351 ,  H04N13/30

摘要： Systems and methods for convergent 3D displays. In one embodiment, the 3D display has a display screen that includes a convergent reflector and a horizontally narrow angle diffuser. The convergent reflector focuses 2D images projected on the diffuser from an array of 2D image projectors to form viewpoints in an eyebox where one viewpoint corresponds to one projector. At a particular viewpoint, the viewer's eye sees a full-screen field of view from a corresponding projector in the array. The narrow angle diffuser diffuses incident rays projected from the 2D image projectors into narrow angular slices so that the views in the eyebox are continuously blended together. The system and methods provide advantages in that only a few projectors are required in the array to provide the viewer with a full-screen field of view and a sufficiently large eyebox for comfortable viewing.

公开(公告)号：US20120300044A1

公开(公告)日：2012-11-29

申请号：US13480432

申请日：2012-05-24

申请人： Clarence E. Thomas ,  David L. Page

发明人： Clarence E. Thomas ,  David L. Page

IPC分类号： H04N17/02 ,  H04N13/04

CPC分类号： H04N13/349 ,  G06T7/73 ,  G06T2207/30204 ,  H04N9/3147 ,  H04N9/3182 ,  H04N9/3194 ,  H04N13/302 ,  H04N13/327 ,  H04N13/363

摘要： Systems and methods for calibrating a 3D display system. In one embodiment, a system includes a display screen, 2D image projectors that project 2D projection images onto the screen and a camera that captures calibration images of the screen. A computer generates the 2D projection images, which include calibration patterns, and processes the captured calibration images. The computer uses the calibration images to calculate corrections based upon the calibration images. The computer can then generate corrected 2D projection images that are projected by the 2D image projectors onto the screen to produce a substantially visually correct 3D image with continuous viewing, true horizontal parallax, and a different view for each eye within a valid viewing zone. The corrections to the images may include corrections to the geometry (including distortion, alignment, etc.) color (including intensity and related parameters).

摘要翻译： 用于校准3D显示系统的系统和方法。 在一个实施例中，系统包括显示屏幕，将2D投影图像投影到屏幕上的2D图像投影仪和捕获屏幕的校准图像的相机。 计算机生成2D投影图像，其包括校准图案，并处理所捕获的校准图像。 计算机使用校准图像根据校准图像计算校正值。 然后，计算机可以生成由2D图像投影仪投影到屏幕上的校正的2D投影图像，以产生具有连续观看，真实水平视差以及在有效观看区域内的每只眼睛的不同视图的基本上视觉正确的3D图像。 对图像的校正可能包括校正几何（包括失真，对齐等）颜色（包括强度和相关参数）。

公开(公告)号：US06342483B1

公开(公告)日：2002-01-29

申请号：US09007678

申请日：1998-01-15

申请人： Jeffrey T. Holt ,  Roy A. Jensen ,  David L. Page ,  Patrice S. Obermiller ,  Cheryl L. Robinson-Benion ,  Marilyn E. Thompson

发明人： Jeffrey T. Holt ,  Roy A. Jensen ,  David L. Page ,  Patrice S. Obermiller ,  Cheryl L. Robinson-Benion ,  Marilyn E. Thompson

IPC分类号： A61K4800

CPC分类号： G01N33/57415 ,  C07K14/82 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention provides a method of detecting and diagnosing pre-invasive breast cancer by identifying differentially expressed genes in early, pre-invasive breast cancer tissue. Differentially expressed genes can be used as genetic markers to indicate the presence of pre-invasive cancerous tissues. Microscopically-directed tissue sampling techniques combined with differential display or differential screening of cDNA libraries are used to determine differential expression of genes in the early stages of breast cancer. Differential expression of genes in preinvasive breast cancer tissue is confirmed by RT-PCR, nuclease protection assays and in-situ hybridization of ductal carcinoma in situ tissue RNA and control tissue RNA. The present invention also provides a method of screening for compounds that induce expression of the BRCA1 gene, whose product negatively regulates cell growth in both normal and malignant mammary epithlial cells. The present invention also relates to gene therapy method using this gene.

摘要翻译： 本发明提供了一种通过在早期浸润性乳腺癌组织中识别差异表达的基因来检测和诊断浸润性乳腺癌的方法。 差异表达的基因可用作遗传标记，以指示侵入性癌组织的存在。 使用与差异显示或差异筛选cDNA文库的显微指导组织取样技术来确定乳腺癌早期基因的差异表达。 通过RT-PCR，核酸酶保护试验和导管癌原位组织RNA和对照组织RNA的原位杂交证实了侵袭性乳腺癌组织中基因的差异表达。 本发明还提供了筛选诱导BRCA1基因表达的化合物的方法，所述BRCA1基因的产物负调节正常和恶性乳腺上皮细胞中的细胞生长。 本发明还涉及使用该基因的基因治疗方法。

公开(公告)号：US06149903A

公开(公告)日：2000-11-21

申请号：US99753

申请日：1998-06-18

申请人： Jeffrey T. Holt ,  Roy A. Jensen ,  Mary-Claire King ,  David L. Page ,  Csilla I. Szabo ,  Thomas L. Jetton ,  Cheryl L. Robinson-Benion ,  Marilyn E. Thompson

发明人： Jeffrey T. Holt ,  Roy A. Jensen ,  Mary-Claire King ,  David L. Page ,  Csilla I. Szabo ,  Thomas L. Jetton ,  Cheryl L. Robinson-Benion ,  Marilyn E. Thompson

IPC分类号： A61K38/00 ,  A61K48/00 ,  A61K49/00 ,  C07K14/47

CPC分类号： A61K49/0004 ,  C07K14/4703 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

摘要： Genetic analysis of familial breast and ovarian cancer indicates that BRCA1 is a tumor suppressor gene. The BRCA1 gene encodes a 190 kDa protein with sequence homology and biochemical analogy to the granin family of proteins. Granins are secreted from endocrine cells via the regulated secretory pathway and are proteolytically cleaved to yield biologically active peptides. BRCA1 protein localizes to secretory vesicles, and was demonstrated to be secreted. Gene transfer of BRCA1 inhibits growth and tumorigenesis of breast and ovarian cancer cells, but not colon or lung cancer cells or fibroblasts, suggesting that BRCA1 encodes a tissue-specific growth inhibitor. Thus, BRCA1 is a secreted growth inhibitor and functions by a mechanism not previously described for tumor suppressor genes. The BRCA2 breast and ovarian cancer gene encodes a protein that also includes a granin region, indicating that the BRCA2 protein is also a secreted tumor suppressor. Therapeutic methods using the BRCA1 and BRCA proteins and genes are also described. A method of screening for the receptors of the BRCA1 protein and BRCA2 proteins is also described.

摘要翻译： 家族性乳腺癌和卵巢癌的遗传分析表明BRCA1是肿瘤抑制基因。 BRCA1基因编码190 kDa的蛋白质，与蛋白质的大豆蛋白家族具有序列同源性和生物化学类比。 通过经调节的分泌途径从内分泌细胞分泌颗粒，并被蛋白水解切割以产生生物活性肽。 BRCA1蛋白定位于分泌囊泡，并被证明是分泌的。 BRCA1的基因转移抑制乳腺和卵巢癌细胞的生长和肿瘤发生，但不抑制结肠或肺癌细胞或成纤维细胞，这表明BRCA1编码组织特异性生长抑制剂。 因此，BRCA1是分泌的生长抑制剂，并且通过以前未被描述用于肿瘤抑制基因的机制起作用。 BRCA2乳腺癌和卵巢癌基因编码的蛋白质也包括一个颗粒蛋白质区域，表明BRCA2蛋白也是分泌的肿瘤抑制因子。 还描述了使用BRCA1和BRCA蛋白和基因的治疗方法。 还描述了筛选BRCA1蛋白和BRCA2蛋白的受体的方法。

公开(公告)号：US5891857A

公开(公告)日：1999-04-06

申请号：US603753

申请日：1996-02-20

申请人： Jeffrey T. Holt ,  Roy A. Jensen ,  Mary-Claire King ,  David L. Page ,  Csilla I. Szabo ,  Thomas L. Jetton ,  Cheryl L. Robinson-Benion ,  Marilyn E. Thompson

发明人： Jeffrey T. Holt ,  Roy A. Jensen ,  Mary-Claire King ,  David L. Page ,  Csilla I. Szabo ,  Thomas L. Jetton ,  Cheryl L. Robinson-Benion ,  Marilyn E. Thompson

IPC分类号： A61K38/00 ,  A61K48/00 ,  A61K49/00 ,  C07K14/47

CPC分类号： A61K49/0004 ,  C07K14/4703 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

摘要： Genetic analysis of familial breast and ovarian cancer indicates that BRCA1 is a tumor suppressor gene. The BRCA1 gene encodes a 190 kDa protein with sequence homology and biochemical analogy to the granin family of proteins. Granins are secreted from endocrine cells via the regulated secretory pathway and are proteolytically cleaved to yield biologically active peptides. BRCA1 protein localizes to secretory vesicles, and was demonstrated to be secreted. Gene transfer of BRCA1 inhibits growth and tumorigenesis of breast and ovarian cancer cells, but not colon or lung cancer cells or fibroblasts, suggesting that BRCA1 encodes a tissue-specific growth inhibitor. Thus, BRCA1 is a secreted growth inhibitor and functions by a mechanism not previously described for tumor suppressor genes. The BRCA2 breast and ovarian cancer gene encodes a protein that also includes a granin region, indicating that the BRCA2 protein is also a secreted tumor suppressor. Therapeutic methods using the BRCA1 and BRCA proteins and genes are also described. A method of screening for the receptors of the BRCA1 protein and BRCA2 proteins is also described.

公开(公告)号：US5677125A

公开(公告)日：1997-10-14

申请号：US182961

申请日：1994-01-14

申请人： Jeffrey T. Holt ,  Roy A. Jensen ,  David L. Page ,  Patrice S. Obermiller ,  Cheryl L. Robinson-Benion

发明人： Jeffrey T. Holt ,  Roy A. Jensen ,  David L. Page ,  Patrice S. Obermiller ,  Cheryl L. Robinson-Benion

IPC分类号： C07K14/82 ,  C12Q1/68 ,  G01N33/574 ,  C12P19/34

CPC分类号： G01N33/57415 ,  C07K14/82 ,  C12Q1/6809 ,  C12Q1/686 ,  C12Q1/6886 ,  C12Q2600/158

摘要： The present invention provides a method of detecting and diagnosing pre-invasive breast cancer by identifying differentially expressed genes in early, pre-invasive breast cancer tissue. Differentially expressed genes can be used as genetic markers to indicate the presence of pre-invasive cancerous tissues. Microscopically-directed tissue sampling techniques combined with differential display or differential screening of cDNA libraries are used to determine differential expression of genes in the early stages of breast cancer. Differential expression of genes in preinvasive breast cancer tissue is confirmed by RT-PCR, nuclease protection assays and in-situ hybridization of ductal carcinoma in situ tissue RNA and control tissue RNA.

摘要翻译： 本发明提供了一种通过在早期浸润性乳腺癌组织中识别差异表达的基因来检测和诊断浸润性乳腺癌的方法。 差异表达的基因可用作遗传标记，以指示侵入性癌组织的存在。 使用与差异显示或差异筛选cDNA文库的显微指导组织取样技术来确定乳腺癌早期基因的差异表达。 通过RT-PCR，核酸酶保护试验和导管癌原位组织RNA和对照组织RNA的原位杂交证实了侵袭性乳腺癌组织中基因的差异表达。