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    Analytical process for testing mixtures for toxic constituents
    1.
    发明授权
    Analytical process for testing mixtures for toxic constituents 失效
    用于测试有毒成分混合物的分析方法

    公开(公告)号：US06238928B1

    公开(公告)日：2001-05-29

    申请号：US08116382

    申请日：1993-09-02

    申请人： Claus Weisemann ,  Wolfgang Kreiss ,  Hans-Georg Rast ,  Günther Eberz

    发明人： Claus Weisemann ,  Wolfgang Kreiss ,  Hans-Georg Rast ,  Günther Eberz

    IPC分类号： G01N3090

    CPC分类号： C12Q1/025 ,  G01N2520/00 ,  Y10T436/255

    摘要： The mixture to be tested for toxic components is first separated into fractions by chromatography. The separated fractions are then contacted with luminescent microorganisms in the chromatographic system itself and the toxicity of the fractions is determined by measurement of the bioluminescence. The chromatographic separation may be carried out either by thin layer chromatography or by column liquid chromatography.

    摘要翻译： 待测试有毒成分的混合物首先通过色谱法分离成级分。 然后将分离的级分与色谱系统中的发光微生物本身接触，并通过测量生物发光来测定级分的毒性。 色谱分离可以通过薄层色谱法或通过柱色谱法进行。

    Method and device for detecting biologically active substances
    2.
    发明授权
    Method and device for detecting biologically active substances 失效
    用于检测生物活性物质的方法和装置

    公开(公告)号：US07695900B2

    公开(公告)日：2010-04-13

    申请号：US11711560

    申请日：2007-02-27

    申请人： Wolfgang Kreiss ,  Guenther Eberz ,  Hans-Georg Rast ,  Claus Weisemann

    发明人： Wolfgang Kreiss ,  Guenther Eberz ,  Hans-Georg Rast ,  Claus Weisemann

    IPC分类号： C12Q1/00 ,  C12Q1/66

    CPC分类号： C12Q1/025 ,  C12Q1/04 ,  Y10S435/975

    摘要： This application claims a method for detecting biologically active substances, comprising the following steps a) providing a support carrying substances to be tested b) providing a suspension containing luminescent microorganisms, c) coating the support with the suspension of microorganisms, d) detecting the biologically active substances on the support by detecting the change in luminescence of the suspension of microorganisms, and e) stimulating the luminescence of the microorganisms before or during detection, and/or f) extending the period of luminescence of the microorganisms by employing substances for regulating and extending the period of luminescence of the microorganisms.

    摘要翻译： 本申请要求一种用于检测生物活性物质的方法，包括以下步骤：a）提供携带待测物质的载体b）提供含有发光微生物的悬浮液，c）用微生物悬浮液涂覆载体，d） 通过检测微生物悬浮液的发光变化，并且e）在检测前或检测期间刺激微生物的发光，和/或f）通过使用用于调节和调节微生物的物质来延长微生物的发光期 延长微生物的发光时间。

    Method and device for detecting biologically active substances
    3.
    发明授权
    Method and device for detecting biologically active substances 失效
    用于检测生物活性物质的方法和装置

    公开(公告)号：US07183113B2

    公开(公告)日：2007-02-27

    申请号：US10424067

    申请日：2003-04-25

    申请人： Wolfgang Kreiss ,  Guenther Eberz ,  Hans-Georg Rast ,  Claus Weisemann

    发明人： Wolfgang Kreiss ,  Guenther Eberz ,  Hans-Georg Rast ,  Claus Weisemann

    IPC分类号： G01N33/53

    CPC分类号： C12Q1/025 ,  C12Q1/04 ,  Y10S435/975

    摘要： The invention claimed herein is a kit for detecting biologically active substances on a support, comprising the luminescent marine bacteria Vibria Fischeri in a form stabilized for transport and storage, one or more cultivation media or the individual components of cultivation media for the microorganism wherein the cultivation media contains 100 mg/l to 500 mg/l of aspartic acid, and optionally additives for extending the period of luminescence selected from N-acylhomoserine lactones, dipeptides, oligopeptides, or their biochemical precursors, and boron compounds.

    摘要翻译： 本文所要求的发明是用于检测载体上的生物活性物质的试剂盒，其包含以稳定运输和储存的形式的发光海洋细菌Vibria Fischeri，一种或多种培养基或微生物培养基的各组分，其中培养 培养基含有100mg / l至500mg / l的天冬氨酸，以及任选的用于延长选自N-酰基高丝氨酸内酯，二肽，寡肽或其生化前体的发光期和硼化合物的添加剂。

    Method and device for detecting biologically active substances
    4.
    发明申请
    Method and device for detecting biologically active substances 失效
    用于检测生物活性物质的方法和装置

    公开(公告)号：US20070154978A1

    公开(公告)日：2007-07-05

    申请号：US11711560

    申请日：2007-02-27

    申请人： Wolfgang Kreiss ,  Gunther Eberz ,  Hans-Georg Rast ,  Claus Weisemann

    发明人： Wolfgang Kreiss ,  Gunther Eberz ,  Hans-Georg Rast ,  Claus Weisemann

    IPC分类号： C12Q1/18 ,  C12N1/20

    CPC分类号： C12Q1/025 ,  C12Q1/04 ,  Y10S435/975

    摘要： This application claims a method for detecting biologically active substances, comprising the following steps a) providing a support carrying substances to be tested b) providing a suspension containing luminescent microorganisms, c) coating the support with the suspension of microorganisms, d) detecting the biologically active substances on the support by detecting the change in luminescence of the suspension of microorganisms, and e) stimulating the luminescence of the microorganisms before or during detection, and/or f) extending the period of luminescence of the microorganisms by employing substances for regulating and extending the period of luminescence of the microorganisms.

    摘要翻译： 本申请要求一种用于检测生物活性物质的方法，包括以下步骤：a）提供携带待测物质的载体b）提供含有发光微生物的悬浮液，c）用微生物悬浮液涂覆载体，d） 通过检测微生物悬浮液的发光变化，并且e）在检测前或检测期间刺激微生物的发光，和/或f）通过使用用于调节和调节微生物的物质来延长微生物的发光期 延长微生物的发光时间。

    Plant-treatment agents
    6.
    发明授权
    Plant-treatment agents 失效
    植物处理剂

    公开(公告)号：US06191071B1

    公开(公告)日：2001-02-20

    申请号：US09297628

    申请日：1999-05-04

    申请人： Joachim Simon ,  Hanns Peter Müller ,  Uwe Priesnitz ,  Hans-Georg Rast

    发明人： Joachim Simon ,  Hanns Peter Müller ,  Uwe Priesnitz ,  Hans-Georg Rast

    IPC分类号： A01N2510

    CPC分类号： A01N25/10

    摘要： The invention concerns novel plant-treatment agents comprising: at least one thermoplastically processable biodegradable polyester amide, optionally in a mixture with one or a plurality of further thermoplastically processable, biodegradable polymer components; at least one agrochemical substance; and optionally additives. The invention further concerns a process for preparing these agents, and their use in the application of agrochemical substances.

    摘要翻译： 本发明涉及新颖的植物处理剂，其包括：至少一种热塑性可加工的可生物降解的聚酯酰胺，任选地与一种或多种另外的热塑性可加工的可生物降解的聚合物组分的混合物; 至少一种农用化学物质; 和任选的添加剂。 本发明还涉及制备这些试剂的方法及其在应用农药物质中的应用。

    Possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives
    7.
    发明授权
    Possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives 有权
    可取代的8-氰基-1-环丙基-7-（2,8-二氮杂双环[4.3.0] - 壬烷-8-基）-6-氟-1,4-二氢-4-氧代-3-喹啉羧酸 酸及其衍生物

    公开(公告)号：US06323213B1

    公开(公告)日：2001-11-27

    申请号：US09125191

    申请日：1998-08-13

    申请人： Stefan Bartel ,  Thomas Jaetsch ,  Thomas Himmler ,  Hans-Georg Rast ,  Werner Hallenbach ,  Ernst Heinen ,  Franz Pirro ,  Martin Scheer ,  Michael Stegemann ,  Hans-Peter Stupp ,  Heinz-Georg Wetzstein

    发明人： Stefan Bartel ,  Thomas Jaetsch ,  Thomas Himmler ,  Hans-Georg Rast ,  Werner Hallenbach ,  Ernst Heinen ,  Franz Pirro ,  Martin Scheer ,  Michael Stegemann ,  Hans-Peter Stupp ,  Heinz-Georg Wetzstein

    IPC分类号： A61K31407

    CPC分类号： C07D471/04 ,  A01N43/90

    摘要： The present invention relates to novel optionally substituted 8-cyano-1-cyclo-propyl-7-(2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and their derivatives, of the general formula (I) in which R1 represents hydrogen, C1-C4-alkyl which is optionally substituted by hydroxyl, methoxy, amino, methylamino or dimethylamino, or (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl, R2 represents hydrogen, benzyl, C1-C3-alkyl, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl, radicals having the structures —CH═CH—COOR3, —CH2CH2COOR3, —CH2CH2CN, —CH2CH2COCH3 or —CH2COCH3, in which R3 represents methyl or ethyl, or a radical of the general structure R4—(NH—CHR5—CO)n—, in which R4 represents hydrogen, C1-C3-alkyl or the radical —COO-tert-butyl, R5 represents hydrogen, C1-C4-alkyl, hydroxyalkyl, aminoalkyl, thioalkyl, carboxyalkyl or benzyl and n is 1 or 2, and Y is oxygen or sulfur, the process for their preparation and their use in antibacterial compositions.

    摘要翻译： 本发明涉及新的任选取代的8-氰基-1-环丙基-7-（2,8-二氮杂双环[4.3.0]壬烷-8-基）-6-氟-1,4-二氢-4- 甲氧基，氨基，甲基氨基或二甲基氨基取代的C 1 -C 4 - 烷基，或（5-甲基-2-羟基喹啉羧酸）或其衍生物，其中R 1表示氢， 氧代-1,3-二氧杂环戊烯-4-基）甲基，R 2表示氢，苄基，C 1 -C 3 - 烷基，（5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基）甲基， 结构-CH = CH-COOR 3，-CH 2 CH 2 COOR 3，-CH 2 CH 2 CN，-CH 2 CH 2 COCH 3或-CH 2 COCH 3，其中R 3表示甲基或乙基，或通式结构R4-（NH-CHR5-CO）n - 的基团，其中R4 代表氢，C 1 -C 3 - 烷基或-COO-叔丁基，R 5表示氢，C 1 -C 4 - 烷基，羟基烷基，氨基烷基，硫代烷基，羧基烷基或苄基，n是1或2，Y是氧或硫， 其制备方法及其在抗菌组合物中的应用。