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公开(公告)号:US11634695B2
公开(公告)日:2023-04-25
申请号:US17072910
申请日:2020-10-16
申请人: Codexis, Inc.
发明人: Jovana Nazor , Robert Osborne , Jack Liang , Jonathan Vroom , Xiyun Zhang , David Entwistle , Rama Voladri , Ravi David Garcia , Jeffrey C. Moore , Shane Grosser , Birgit Kosjek , Matthew Truppo
摘要: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.
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公开(公告)号:US20220154164A1
公开(公告)日:2022-05-19
申请号:US17537941
申请日:2021-11-30
申请人: Codexis, Inc.
发明人: Jovana Nazor , Vesna Mitchell , David Elgart , Katrina W. Lexa , Nikki Dellas , Robert Kevin Orr , Oscar Alvizo , Ravi David Garcia , Judy Victoria Antonio Viduya , Courtney Dianne Moffett
摘要: The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
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公开(公告)号:US20190211318A1
公开(公告)日:2019-07-11
申请号:US16306029
申请日:2017-06-09
申请人: Codexis, Inc.
CPC分类号: C12N9/2445 , C12N9/1051 , C12N15/70 , C12P19/14 , C12P19/18 , C12Y302/01021 , C12Y302/01169
摘要: The present invention provides engineered β-glucosidase (BGL) enzymes, polypeptides having BGL activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the enzymes, and methods of using the engineered BGL enzymes to make products with β-glucose linkages.
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公开(公告)号:US11299723B2
公开(公告)日:2022-04-12
申请号:US16306029
申请日:2017-06-09
申请人: Codexis, Inc.
摘要: The present invention provides engineered β-glucosidase (BGL) enzymes, polypeptides having BGL activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the enzymes, and methods of using the engineered BGL enzymes to make products with β-glucose linkages.
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公开(公告)号:US20220056431A1
公开(公告)日:2022-02-24
申请号:US17522370
申请日:2021-11-09
申请人: Codexis, Inc.
发明人: Scott J. Novick , Ravi David Garcia , Charlene Ching , Nikki Dellas , David Entwistle , Vesna Mitchell
IPC分类号: C12N9/88
摘要: The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia lyase (PAL) polypeptides. Methods for producing PAL enzymes are also provided. In some embodiments, the engineered PAL polypeptides are optimized to provide enhanced catalytic activities that are useful under industrial process conditions for the production of pharmaceutical compounds.
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公开(公告)号:US11198861B2
公开(公告)日:2021-12-14
申请号:US16441458
申请日:2019-06-14
申请人: Codexis, Inc.
发明人: Scott J. Novick , Ravi David Garcia , Charlene Ching , Nikki Dellas , David Entwistle , Vesna Mitchell
摘要: The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia lyase (PAL) polypeptides. Methods for producing PAL enzymes are also provided. In some embodiments, the engineered PAL polypeptides are optimized to provide enhanced catalytic activities that are useful under industrial process conditions for the production of pharmaceutical compounds.
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公开(公告)号:US20210032605A1
公开(公告)日:2021-02-04
申请号:US17072910
申请日:2020-10-16
申请人: Codexis, Inc.
发明人: Jovana Nazor , Robert Osborne , Jack Liang , Jonathan Vroom , Xiyun Zhang , David Entwistle , Rama Voladri , Ravi David Garcia , Jeffrey C. Moore , Shane Grosser , Birgit Kosjek , Matthew Truppo
摘要: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.
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8.
公开(公告)号:US20220213518A1
公开(公告)日:2022-07-07
申请号:US17600345
申请日:2020-04-23
申请人: Codexis, Inc.
发明人: Xiang Yi , Oscar Alvizo , Ravi David Garcia , David Entwistle , Charlene Ching , James Nicholas Riggins
摘要: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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公开(公告)号:US20220090039A1
公开(公告)日:2022-03-24
申请号:US17460141
申请日:2021-08-27
发明人: Chinping Chng , Nikki Dellas , Ravi David Garcia , Moulay Hicham Alaoui Ismaili , Kristen Jean Vallieu , Kerryn McCluskie
摘要: The present invention provides engineered protease polypeptides and compositions thereof. The engineered protease polypeptides have been optimized to provide improved activity, improved thermostability, protease stability, autolytic stability, and stability under a range of pH conditions, including acidic (pH 7) conditions. The invention also relates to the use of the compositions comprising the engineered protease polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered protease polypeptides, as well as methods for making the engineered polynucleotides and protease polypeptides.
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公开(公告)号:US20220090038A1
公开(公告)日:2022-03-24
申请号:US17460147
申请日:2021-08-27
摘要: The present invention provides engineered amylase polypeptides and compositions thereof. The engineered amylase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH
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