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1.
公开(公告)号:US20220213518A1
公开(公告)日:2022-07-07
申请号:US17600345
申请日:2020-04-23
申请人: Codexis, Inc.
发明人: Xiang Yi , Oscar Alvizo , Ravi David Garcia , David Entwistle , Charlene Ching , James Nicholas Riggins
摘要: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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公开(公告)号:US11236311B2
公开(公告)日:2022-02-01
申请号:US16938793
申请日:2020-07-24
申请人: Codexis, Inc.
发明人: Mathew G. Miller , Chinping Chng , Oscar Alvizo , Melissa Ann Mayo , James Nicholas Riggins , Xiang Yi , Jonathan S. Penfield , Gjalt W. Huisman , Jared Davis , Yasushi Saotome
摘要: The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.
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公开(公告)号:US20210261940A1
公开(公告)日:2021-08-26
申请号:US17316165
申请日:2021-05-10
申请人: Codexis, Inc.
发明人: Scott J. Novick , Xiang Yi , Nikki Dellas , Oscar Alvizo , Jovana Nazor , Da Duan , Vesna Mitchell , Jonathan Vroom , Santhosh Sivaramakrishnan , Nandhitha Subramanian , Jeffrey C. Moore , Mark Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Grant S. Murphy , Nicholas Marshall , Jay Russell , Keith A. Canada
摘要: The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号:US10745681B2
公开(公告)日:2020-08-18
申请号:US15861849
申请日:2018-01-04
申请人: Codexis, Inc.
发明人: Oscar Alvizo , David Elgart , Robert Kevin Orr , James Nicholas Riggins , Anna Fryszkowska , Katrina W. Lexa , Xiang Yi , Da Duan , Courtney Dianne Moffett , Nikki Dellas , Vesna Mitchell
摘要: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.
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公开(公告)号:US20200010823A1
公开(公告)日:2020-01-09
申请号:US16460062
申请日:2019-07-02
申请人: Codexis, Inc.
发明人: Scott J. Novick , Xiang Yi , Nikki Dellas , Oscar Alvizo , Jovana Nazor , Da Duan , Vesna Mitchell , Jonathan Vroom , Santhosh Sivaramakrishnan , Nandhitha Subramanian , Jeffrey C. Moore , Mark Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Grant Murphy , Nicholas M. Marshall , Jay Russell , Keith A. Canada
摘要: The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号:US20220186197A1
公开(公告)日:2022-06-16
申请号:US17558454
申请日:2021-12-21
申请人: Codexis, Inc.
发明人: Mathew G. Miller , Chinping Chng , Oscar Alvizo , Melissa Ann Mayo , James Nicholas Riggins , Xiang Yi , Jonathan S. Penfield , Gjalt W. Huisman , Jared Davis , Yasushi Saotome
摘要: The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.
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公开(公告)号:US20210054357A1
公开(公告)日:2021-02-25
申请号:US17091479
申请日:2020-11-06
申请人: Codexis, Inc.
发明人: Oscar Alvizo , David Elgart , Robert Kevin Orr , James Nicholas Riggins , Anna Fryszkowska , Katrina W. Lexa , Xiang Yi , Da Duan , Courtney Dianne Moffett , Nikki Dellas , Vesna Mitchell
摘要: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.
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公开(公告)号:US20190002850A1
公开(公告)日:2019-01-03
申请号:US16012462
申请日:2018-06-19
发明人: Mathew G. Miller , Chinping Chng , Oscar Alvizo , Melissa Ann Mayo , James Nicholas Riggins , Xiang Yi , Jonathan S. Penfield , Gjalt W. Huisman , Jared Davis , Yasushi Saotome
摘要: The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.
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公开(公告)号:US11591588B2
公开(公告)日:2023-02-28
申请号:US17091479
申请日:2020-11-06
申请人: Codexis, Inc.
发明人: Oscar Alvizo , David Elgart , Robert Kevin Orr , James Nicholas Riggins , Anna Fryszkowska , Katrina W. Lexa , Xiang Yi , Da Duan , Courtney Dianne Moffett , Nikki Dellas , Vesna Mitchell
摘要: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.
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10.
公开(公告)号:US20220145268A1
公开(公告)日:2022-05-12
申请号:US17600357
申请日:2020-04-23
申请人: Codexis, Inc.
发明人: Xiang Yi , Oscar Alvizo , Ravi David Garcia , David Entwistle , Charlene Ching , James Nicholas Riggins , Nandhitha Subramanian
摘要: The present application provides engineered glucose dehydrogenase polypeptides having imine reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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