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公开(公告)号:US20220106575A1
公开(公告)日:2022-04-07
申请号:US17553455
申请日:2021-12-16
申请人: Codexis, Inc.
发明人: Oscar Alvizo , Nicholas J. Agard , Xinkai Xie , David Entwistle , Birgit Kosjek
摘要: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号:US11236308B2
公开(公告)日:2022-02-01
申请号:US16874574
申请日:2020-05-14
申请人: Codexis, Inc.
发明人: Oscar Alvizo , Nicholas J. Agard , Xinkai Xie , David Entwistle , Birgit Kosjek
摘要: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号:US20200347365A1
公开(公告)日:2020-11-05
申请号:US16874574
申请日:2020-05-14
申请人: Codexis, Inc.
发明人: Oscar Alvizo , Nicholas J. Agard , Xinkai Xie , David Entwistle , Birgit Kosjek
摘要: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号:US10696953B2
公开(公告)日:2020-06-30
申请号:US15543535
申请日:2016-02-05
申请人: Codexis, Inc.
发明人: Oscar Alvizo , Nicholas J. Agard , Xinkai Xie , David Entwistle , Birgit Kosjek
摘要: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号:US20180002676A1
公开(公告)日:2018-01-04
申请号:US15543535
申请日:2016-02-05
申请人: Codexis, Inc.
发明人: Oscar Alvizo , Nicholas J. Agard , Xinkai Xie , David Entwistle , Birgit Kosjek
摘要: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号:US20150087028A1
公开(公告)日:2015-03-26
申请号:US14384133
申请日:2013-03-12
申请人: Codexis, Inc.
发明人: Behnaz Behrouzian , Xinkai Xie , Kui Chan , Xiyun Zhang , Vesna Mitchell , Douglas A. Hattendorf
CPC分类号: C12P19/14 , C12N9/2434 , C12N9/2437 , C12P7/04 , C12P7/10 , C12P7/18 , C12P7/20 , C12P7/40 , C12P13/001 , C12P19/02 , C12P2203/00 , C12Y302/01091 , C13K1/02 , Y02E50/16
摘要: The invention relates to recombinant expression of variant forms of M. thermophila CBH1a and homologs thereof, having improved thermoactivity, specific activity, and other desirable properties. Also provided are methods for producing ethanol and other valuable organic compounds by combining cellobiohydrolase variants with cellulosic materials.
摘要翻译: 本发明涉及具有改进的热活性,比活性和其它所需性质的嗜热绵羊杆菌CBH1a及其同源物的变体形式的重组表达。 还提供了通过将纤维二糖水解酶变体与纤维素材料结合来生产乙醇和其它有价值的有机化合物的方法。
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