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公开(公告)号：US20220090039A1
公开(公告)日：2022-03-24
申请号：US17460141
申请日：2021-08-27
发明人： Chinping Chng , Nikki Dellas , Ravi David Garcia , Moulay Hicham Alaoui Ismaili , Kristen Jean Vallieu , Kerryn McCluskie
摘要： The present invention provides engineered protease polypeptides and compositions thereof. The engineered protease polypeptides have been optimized to provide improved activity, improved thermostability, protease stability, autolytic stability, and stability under a range of pH conditions, including acidic (pH 7) conditions. The invention also relates to the use of the compositions comprising the engineered protease polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered protease polypeptides, as well as methods for making the engineered polynucleotides and protease polypeptides.
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公开(公告)号：US20210062168A1
公开(公告)日：2021-03-04
申请号：US17005913
申请日：2020-08-28
发明人： Chinping Chng , William Casey Hallows , Judy Victoria Antonio Viduya , Nikki Dellas , Stephanie Sue Galanie , Kristen Jean Vallieu
摘要： The present invention provides engineered lipase polypeptides and compositions thereof. The engineered lipase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH 7) conditions. The invention also relates to the use of the compositions comprising the engineered lipase polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered lipase polypeptides, as well as methods for making the engineered polynucleotides and lipase polypeptides.
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公开(公告)号：US11427813B2
公开(公告)日：2022-08-30
申请号：US16721102
申请日：2019-12-19
申请人： Codexis, Inc.
发明人： William Casey Hallows , Kristen Jean Vallieu , Nikki Dellas , Yu Zhu , Judy Victoria Antonio Viduya , Chinping Chng , Antoinette Sero , Gjalt W. Huisman , Rachel Cathleen Botham , Moulay Hicham Alaoui Ismaili
摘要： The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH 7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
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公开(公告)号：US20210269787A1
公开(公告)日：2021-09-02
申请号：US17186462
申请日：2021-02-26
申请人： Codexis, Inc.
发明人： William Casey Hallows , Nikki Dellas , Yu Zhu , Judy Victoria Antonio Viduya , Chinping Chng , Antoinette Sero , Rachel Cathleen Botham , David William Homan , Moulay Hicham Alaoui Ismaili , Jonathan Vroom , Adam P. Silverman , Kristen Jean Vallieu , Charu Shukla Reddy , Kerryn McCluskie
摘要： The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH 7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
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公开(公告)号：US20220403362A1
公开(公告)日：2022-12-22
申请号：US17749034
申请日：2022-05-19
申请人： Codexis, Inc.
发明人： Kierra Aleece Franklin , Stephanie Sue Galanie , Gjalt W. Huisman , Nikki D. Kruse , Kerryn McCluskie , Vesna Mitchell , Leann Quertinmont Teadt , Kristen Jean Vallieu
摘要： The present invention provides engineered methionine gamma lyase polypeptides and compositions thereof. The engineered methionine gamma lyase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH
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公开(公告)号：US20220356458A1
公开(公告)日：2022-11-10
申请号：US17814371
申请日：2022-07-22
申请人： Codexis, Inc.
发明人： William Casey Hallows , Kristen Jean Vallieu , Nikki Dellas , Yu Zhu , Judy Victoria Antonio Viduya , Chinping Chng , Antoinette Sero , Gjalt W. Huisman , Rachel Cathleen Botham , Moulay Hicham Alaoui Ismaili
摘要： The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (pH 7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
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公开(公告)号：US20210269789A1
公开(公告)日：2021-09-02
申请号：US17255217
申请日：2019-06-27
申请人： Codexis, Inc.
发明人： Xiang Yi , Nikki Dellas , James Nicholas Riggins , Chinping Chng , Nicholas J. Agard , Kristen Jean Vallieu , Gjalt W. Huisman
IPC分类号： C12N9/88
摘要： The present invention provides engineered branched chain ketoacid decarboxylase (KdcA) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered branched chain ketoacid decarboxylase (KdcA) polypeptides. In some embodiments, the engineered KdcA polypeptides are optimized to provide enhanced catalytic activity, as well as reduced sensitivity to proteolysis and increased tolerance to storage at elevated temperatures. The present invention also provides methods for the use of the compositions comprising the engineered KdcA polypeptides for therapeutic and industrial purposes.
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公开(公告)号：US20210238575A1
公开(公告)日：2021-08-05
申请号：US17166934
申请日：2021-02-03
申请人： Codexis, Inc.
发明人： Joyce Liu , Leann Quertinmont Teadt , Nikki Dellas , Stephan Jenne , Faye Loan Du , Kristen Jean Vallieu , Kerryn McCluskie
IPC分类号： C12N9/88
摘要： The present invention provides engineered leucine decarboxylase (LDC) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered leucine decarboxylase (LDC) polypeptides. In some embodiments, the engineered LDC polypeptides are optimized to provide enhanced catalytic activity, as well as reduced sensitivity to proteolysis, and/or increased tolerance to low pH environments. In some embodiments, the engineered LDC polypeptides are optimized to provide improved storage stability. The present invention also provides methods for the use of the compositions comprising the engineered LDC polypeptides for therapeutic and industrial purposes.
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