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    DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS
    4.
    发明申请
    DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS 审中-公开
    用于密封裸露开口的装置和方法

    公开(公告)号：US20160262737A1

    公开(公告)日：2016-09-15

    申请号：US15062749

    申请日：2016-03-07

    Applicant: Cook Medical Technologies LLC ,  Cook Biotech Incorporated

    Inventor： Ram H. Paul, JR. ,  Cleon Stanley ,  Brian L. Bates ,  F. Joseph Obermiller ,  Thomas A. Osborne ,  Sean D. Chambers

    IPC: A61B17/00

    Abstract: Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.

    Abstract translation: 除此之外，还公开了用于医​​疗密封容器或壁中的开口的装置和方法。 例如，在医疗应用中，提供输送管用于通过护套插入血管（例如血管）中。 固定在细丝上的圆顶形密封件，吸收性和/或可压缩缓冲器以及锁定构件设置在输送管中。 输送管被构造成使得其可以通过护套插入到容器中。 在灯丝上保持张力以将密封件保持在管或鞘上。 护套被拉出，同时拉出管子，将密封件留在血管壁的开口处。 锁定构件将缓冲器压靠在容器的外部，并且灯丝将密封件保持在与容器内部的适当位置。

    COATED IMPLANTABLE MEDICAL DEVICE
    5.
    发明申请
    COATED IMPLANTABLE MEDICAL DEVICE 审中-公开
    涂层可植入医疗器械

    公开(公告)号：US20150150696A1

    公开(公告)日：2015-06-04

    申请号：US14622294

    申请日：2015-02-13

    Applicant: Cook Medical Technologies LLC

    Inventor： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III

    IPC: A61F2/82 ,  A61L31/16 ,  A61L31/10

    CPC classification number: A61F2/82 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/06 ,  A61L2420/08 ,  C08L29/04

    Abstract: Bioactive-coated medical devices are provided, including coated vascular stents. The medical device coating can include a coating layer posited over at least a portion of the medical device surface, and can include a butyl methacrylate polymer or an ethylene-vinyl acetate copolymer in combination with a bioactive material that can function as both an immunosuppressive agent and an antiproliferative agent. Optionally, multilayer coatings can further include an adhesion promoting layer comprising parylene positioned between the coating layer and the medical device surface, a porous layer comprising butyl methacrylate positioned over at least a portion of the coating layer, or both. The coating layer preferably comprises between about 0.5 and 2.0 μg/mm2 of the bioactive material on the outer surface of the medical device. The bioactive material can be absorbed into the coating layer, which can have a thickness of between about 0.5 μm to about 5 μm.

    Abstract translation: 提供生物活性涂层医疗器械，包括涂层血管支架。 医疗器械涂层可以包括位于医疗器械表面的至少一部分上的涂层，并且可以包括甲基丙烯酸丁酯聚合物或乙烯 - 乙酸乙烯酯共聚物与可以用作免疫抑制剂和生物活性物质的生物活性材料 抗增生剂。 任选地，多层涂层还可以包括粘合促进层，其包括定位在涂层和医疗器件表面之间的聚对二甲苯，包含位于涂层的至少一部分上的甲基丙烯酸丁酯的多孔层，或两者。 涂层优选在医疗装置的外表面上包含约0.5至2.0μg/ mm 2的生物活性材料。 生物活性物质可以被吸收到涂层中，其可以具有约0.5μm至约5μm的厚度。

    COATED MEDICAL DEVICE
    8.
    发明申请
    COATED MEDICAL DEVICE 审中-公开

    公开(公告)号：US20190351197A9

    公开(公告)日：2019-11-21

    申请号：US15810721

    申请日：2017-11-13

    Applicant: Cook Medical Technologies LLC

    Inventor： Brian L. Bates ,  Anthony O. Ragheb ,  Joseph M. Stewart, IV ,  William J. Bourdeau ,  Brian D. Choules ,  James D. Purdy ,  Neal E. Fearnot

    IPC: A61M25/10 ,  A61L29/08 ,  A61F2/844 ,  A61F2/958 ,  A61L27/54 ,  A61F2/82 ,  A61L29/16 ,  A61L31/16

    Abstract: A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

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