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1.发明申请3-ARYL-4-HYDROXYFURANONE COMPOUNDS AND THE HUMAN AND ANIMAL HEALTH USE THEREOF 失效3-ARYL-4-HYDROXYFURANONE化合物及其人类和动物健康用途公开(公告)号：US20090036439A1
公开(公告)日：2009-02-05
申请号：US12233709
申请日：2008-09-19
申请人： Craig Eugene Caufield , Schuyler Adam Antane , Koi Michele Morris , Shaughnessy McGrath Naughton , Dominick Anthony Quagliato , Patrick Michael Andrae , Annmarie Enos , John F. Chiarello
发明人： Craig Eugene Caufield , Schuyler Adam Antane , Koi Michele Morris , Shaughnessy McGrath Naughton , Dominick Anthony Quagliato , Patrick Michael Andrae , Annmarie Enos , John F. Chiarello
IPC分类号： A01N43/84 , C07D307/26 , A01N43/08 , C07D405/02 , A01N43/60 , A01N43/40 , C07D233/54 , A01N43/50 , C07D231/10 , A01N43/56 , C07D413/02 , A01P5/00
CPC分类号： C07D307/34 , A01N43/08 , A01N43/10 , A01N43/30 , A01N43/36 , A01N43/40 , A01N43/56 , A01N43/60 , A01N43/84 , A01N47/06 , C07D405/06 , C07D405/10 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/14
摘要： The present invention provides a compound of formula I and the use thereof for the inhibition of bacterial cell wall biosynthesis and for the therapeutic treatment of bacterial infection or disease in a patient in need thereof. The present invention also provides the use of the formula I compound for the control of ecto- or endoparasites in homeothermic animals.
摘要翻译： 本发明提供式I化合物及其用于抑制细菌细胞壁生物合成和用于治疗有需要的患者的细菌感染或疾病的用途。 本发明还提供式I化合物用于控制恒温动物体内外寄生虫或内寄生虫的用途。
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2.发明授权3-aryl-4-hydroxyfuranone compounds and the human and animal health use thereof 失效3-芳基-4-羟基呋喃酮化合物及其人和动物健康用途公开(公告)号：US07666904B2
公开(公告)日：2010-02-23
申请号：US12233709
申请日：2008-09-19
申请人： Craig Eugene Caufield , Schuyler Adam Antane , Koi Michele Morris , Shaughnessy McGrath Naughton , Dominick Anthony Quagliato , Patrick Michael Andrae , Annmarie Enos , John F. Chiarello
发明人： Craig Eugene Caufield , Schuyler Adam Antane , Koi Michele Morris , Shaughnessy McGrath Naughton , Dominick Anthony Quagliato , Patrick Michael Andrae , Annmarie Enos , John F. Chiarello
IPC分类号： A61K31/341 , C07D307/60
CPC分类号： C07D307/34 , A01N43/08 , A01N43/10 , A01N43/30 , A01N43/36 , A01N43/40 , A01N43/56 , A01N43/60 , A01N43/84 , A01N47/06 , C07D405/06 , C07D405/10 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/14
摘要： The present invention provides a compound of formula I and the use thereof for the inhibition of bacterial cell wall biosynthesis and for the therapeutic treatment of bacterial infection or disease in a patient in need thereof. The present invention also provides the use of the formula I compound for the control of ecto- or endoparasites in homeothermic animals.
摘要翻译： 本发明提供式I化合物及其用于抑制细菌细胞壁生物合成和用于治疗有需要的患者的细菌感染或疾病的用途。 本发明还提供式I化合物用于控制恒温动物体内外寄生虫或内寄生虫的用途。
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3.发明授权3-aryl-4-hydroxyfuranone compounds and the human and animal health use thereof 失效3-芳基-4-羟基呋喃酮化合物及其人和动物健康用途公开(公告)号：US07495027B2
公开(公告)日：2009-02-24
申请号：US10915637
申请日：2004-08-09
申请人： Craig Eugene Caufield , Schuyler Adam Antane , Koi Michele Morris , Shaughnessy McGrath Naughton , Dominick Anthony Quagliato , Patrick Michael Andrae , Annmarie Enos , John F. Chiarello
发明人： Craig Eugene Caufield , Schuyler Adam Antane , Koi Michele Morris , Shaughnessy McGrath Naughton , Dominick Anthony Quagliato , Patrick Michael Andrae , Annmarie Enos , John F. Chiarello
IPC分类号： A61K31/341
CPC分类号： C07D307/34 , A01N43/08 , A01N43/10 , A01N43/30 , A01N43/36 , A01N43/40 , A01N43/56 , A01N43/60 , A01N43/84 , A01N47/06 , C07D405/06 , C07D405/10 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/14
摘要： The present invention provides a compound of formula I and the use thereof for the inhibition of bacterial cell wall biosynthesis and for the therapeutic treatment of bacterial infection or disease in a patient in need thereof. The present invention also provides the use of the formula I compound for the control of ecto- or endoparasites in homeothermic animals
摘要翻译： 本发明提供式I化合物及其用于抑制细菌细胞壁生物合成和用于治疗有需要的患者的细菌感染或疾病的用途。 本发明还提供式I化合物用于控制恒温动物体内外寄生虫或内寄生虫的用途
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4.发明授权Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation 失效氨基-5-（5元）杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途公开(公告)号：US07417047B2
公开(公告)日：2008-08-26
申请号：US11478122
申请日：2006-06-29
申请人： Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
发明人： Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
IPC分类号： A61K31/4178 , A61K31/4439 , A61K31/506 , C07D403/04 , C07D401/14
CPC分类号： C07D417/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。
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5.发明申请Amino-5-(5-membered)heteroarylimidazolone Compounds And The Use Thereof For Beta-secretase Modulation 审中-公开氨基-5-（5元）杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途公开(公告)号：US20100168106A1
公开(公告)日：2010-07-01
申请号：US12719606
申请日：2010-03-08
申请人： Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
发明人： Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
IPC分类号： A61K31/5377 , C07D403/14 , A61K31/506 , C07D401/14 , A61K31/4439 , A61K31/497 , C07D413/14 , A61P25/28
CPC分类号： C07D417/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles
摘要翻译： 本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制和分泌（BACE）和治疗和淀粉样沉积物和神经原纤维缠结的方法
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![Dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol] compounds for the inhibition of beta-secretase](/abs-image/US/2009/09/01/US07582667B2/abs.jpg.150x150.jpg)
6.发明授权Dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol] compounds for the inhibition of beta-secretase 失效用于抑制β-分泌酶的二氢螺[二苯并[a，d] [7]环烯-5,4'-咪唑]化合物公开(公告)号：US07582667B2
公开(公告)日：2009-09-01
申请号：US11710666
申请日：2007-02-23
IPC分类号： A01N43/50 , C07D233/00
CPC分类号： C07D235/02 , C07D401/04 , C07D403/04
摘要： The present invention provides a 10,11-dihydrospiro[dibenzo[a,d][7]annulene -5,4′-imidazol]-5′(1′H)-one compound of formula I Also provided are methods and compositions for the inhibition of β-secretase (BACE) and the treatment of β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的10,11-二氢螺[二苯并[a，d] [7]环烯-5,4'-咪唑] -5'（1'H） - 酮化合物。还提供了用于 抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结。
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![Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase](/abs-image/US/2007/08/30/US20070203116A1/abs.jpg.150x150.jpg)
7.发明申请Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase 失效用于抑制β-分泌酶的二氢螺[二苯并[a，d] [7]环烯-5,4'-咪唑]化合物公开(公告)号：US20070203116A1
公开(公告)日：2007-08-30
申请号：US11710666
申请日：2007-02-23
IPC分类号： A61K31/551 , A61K31/506 , A61K31/4188 , C07D487/10
CPC分类号： C07D235/02 , C07D401/04 , C07D403/04
摘要： The present invention provides a 10,11-dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol]-5′(1′H)-one compound of formula I Also provided are methods and compositions for the inhibition of β-secretase (BACE) and the treatment of β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的10,11-二氢螺[二苯并[a，d] [7]环烯-5,4'-咪唑] -5'（1'H） - 酮化合物。还提供了用于 抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结。
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8.发明授权Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation 失效氨基-5-（5元）杂芳基咪唑酮化合物及其用于分泌酶调节的用途公开(公告)号：US07705030B2
公开(公告)日：2010-04-27
申请号：US12180795
申请日：2008-07-28
申请人： Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
发明人： Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
IPC分类号： A61K31/4178 , A61K31/4439 , A61K31/506 , C07D403/14 , C07D401/14 , C07D233/88
CPC分类号： C07D417/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了其用于抑制和分泌（BACE）和治疗和淀粉样蛋白沉积物和神经原纤维缠结的方法。
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9.发明授权Substituted arylsulfides, arylsulfoxides and arylsulfones as beta-3 adrenergic receptor agonists 失效取代的芳基硫醚，芳基亚砜和芳基砜作为β-3肾上腺素能受体激动剂公开(公告)号：US06458817B1
公开(公告)日：2002-10-01
申请号：US09903802
申请日：2001-07-12
IPC分类号： C07D27106
CPC分类号： C07D271/06 , C07D249/18 , C07D413/04 , C07D413/12
摘要： This invention provides compounds of Formula I having the structure wherein R1, R2, R3, R4, R5, R6, Y, Z, m, n, and are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
摘要翻译： 本发明提供具有其中R1，R2，R3，R4，R5，R6，Y，Z，m，n和如上所定义的结构的式I化合物或其药学上可接受的盐，其可用于治疗或抑制代谢 与胰岛素抵抗或高血糖相关的疾病（通常与肥胖或葡萄糖不耐受相关），动脉粥样硬化，胃肠道疾病，神经源性炎症，青光眼，高眼压症和尿频; 并且特别可用于治疗或抑制II型糖尿病。
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10.发明申请AMINO-5-(5-MEMBERED)HETERO-ARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR beta-SECRETASE MODULATION 失效AMINO-5-（5-MEMBERED）异星形霉素化合物及其用于β-分泌酶调节的用途公开(公告)号：US20080306091A1
公开(公告)日：2008-12-11
申请号：US12180795
申请日：2008-07-28
申请人： Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
发明人： Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
IPC分类号： C07D403/10 , A61K31/506 , C07D401/10 , A61K31/4439 , A61K31/4152 , A61K31/4168 , A61K31/4178 , C07D233/96 , C07D231/10 , C07D413/10 , A61K31/5377
CPC分类号： C07D417/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles
摘要翻译： 本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样蛋白沉积物和神经原纤维缠结的方法
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