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公开(公告)号：US20060052397A1
公开(公告)日：2006-03-09
申请号：US10513869
申请日：2003-04-25
申请人： Cristina Alonso-Alija , Erwin Bischoff , Klaus Munter , Johannes-Peter Stasch , Elke Stahl , Stefan Weigand , Achim Feurer
发明人： Cristina Alonso-Alija , Erwin Bischoff , Klaus Munter , Johannes-Peter Stasch , Elke Stahl , Stefan Weigand , Achim Feurer
IPC分类号： A61K31/506 , C07D471/02
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compounds which stimulate soluble guanylate cyclase, to the preparation thereof and to the use thereof as medicaments, in particular as medicaments for the treatment of cardiovascular disorders and/or sexual dysfunction.
摘要翻译： 本发明涉及刺激可溶性鸟苷酸环化酶，其制备及其作为药物的用途，特别是作为用于治疗心血管疾病和/或性功能障碍的药物的化合物。
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2.发明申请Derivatives of 2-(1-benzyl-1h-pyrazolo(3,4-b)pyridine-3-yl)- 5(-4-pyridiny)l-4- pyrimidinamines and the use thereof as quanylate cyclase stimulators 有权2-（1-苄基-1h-吡唑并（3,4-b）吡啶-3-基）-5（ - 4-吡啶基）-1-嘧啶胺的衍生物及其作为喹啉甲酸酯环化酶刺激剂的用途公开(公告)号：US20050222170A1
公开(公告)日：2005-10-06
申请号：US10514909
申请日：2003-05-05
IPC分类号： A61K31/506 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P15/10 , A61P15/12 , A61P43/00 , C07D471/04 , C07D487/02
CPC分类号： C07D471/04
摘要： The invention relates to novel chemical compounds of formula (I), which stimulate soluble guanylate cyclase, to the production and use thereof as medicament, particularly in the treatment of cardiovascular diseases and/or sexual dysfunction (I), wherein R1″ represents chlorine, cyano, trifluoromethyl or methoxy and R2 represents hydrogen or fluorine or R1 represents fluorine and R2 represents fluorine. The invention also relates to the salts, isomers and hydrates of said compounds.
摘要翻译： 本发明涉及促进可溶性鸟苷酸环化酶的新型式（I）化合物，其生产和用途作为药物，特别是治疗心血管疾病和/或性功能障碍（I），其中R 1 “O”表示氯，氰基，三氟甲基或甲氧基，R 2表示氢或氟，或者R 1表示氟，R“ 代表氟。 本发明还涉及所述化合物的盐，异构体和水合物。
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3.发明申请Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors 失效杂环氧基取代的苯基氨基嘧啶作为rho激酶抑制剂公开(公告)号：US20060241127A1
公开(公告)日：2006-10-26
申请号：US10531889
申请日：2003-10-16
申请人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Perez , Heimo Ehmke
发明人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Perez , Heimo Ehmke
IPC分类号： A61K31/519 , A61K31/513 , A61K31/506 , C07D487/04 , C07D403/02
CPC分类号： C07D401/14 , C07D403/12 , C07D471/04
摘要： The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-Kinase.
摘要翻译： 本发明涉及杂芳氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物。 本发明化合物抑制Rho-激酶。
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公开(公告)号：US20080269268A1
公开(公告)日：2008-10-30
申请号：US11587630
申请日：2005-04-14
申请人： Hartmut Schirok , Johannes-Peter Stasch , Raimund Kast , Klaus Munter , Mark Jean Gnoth , Santiago Figureoa Perez , Michael Thutewohl , Samir Bennabi , Dieter Lang , Joachim Mittendorf , Martin Radtke , Heimo Ehmke
发明人： Hartmut Schirok , Johannes-Peter Stasch , Raimund Kast , Klaus Munter , Mark Jean Gnoth , Santiago Figureoa Perez , Michael Thutewohl , Samir Bennabi , Dieter Lang , Joachim Mittendorf , Martin Radtke , Heimo Ehmke
IPC分类号： A61K31/506 , C07D401/14 , A61P9/00 , A61P15/00
CPC分类号： C07D471/04
摘要： The invention relates to substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译： 本发明涉及取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。
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5.发明申请公开(公告)号：US20080139595A1
公开(公告)日：2008-06-12
申请号：US11547975
申请日：2005-03-30
申请人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
发明人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
IPC分类号： C07D487/04 , A61K31/506 , A61P9/00
CPC分类号： C07D471/04
摘要： The invention relates to hetaryloxy-substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译： 本发明涉及苯甲酰氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。
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公开(公告)号：US4297512A
公开(公告)日：1981-10-27
申请号：US68849
申请日：1979-08-22
IPC分类号： C07B61/00 , B01J23/00 , C07C67/00 , C07C209/00 , C07C209/48 , C07C209/64 , C07C211/05 , C07C85/12
CPC分类号： C07C209/48
摘要： An improved process for the preparation of triethylamine by gas phase catalytic hydrogenation of acetonitrile is disclosed, the improvement residing in employing as the catalyst a supported noble metal of Group VIII of the periodic system catalyst where the support comprises lithium aluminum spinel. The process can be carried out in the presence of up to 5% by weight of monoethylamine and/or diethylamine. The process is conducted at 80.degree.-115.degree. C. and under a pressure of 1 to 60 bars.
摘要翻译： 公开了通过气相催化氢化乙腈制备三乙胺的改进方法，其改进在于使用周期性体系催化剂的负载型贵金属作为催化剂，其中载体包含锂铝尖晶石。 该方法可以在高达5重量％的单乙胺和/或二乙胺的存在下进行。 该方法在80-115℃和1至60巴的压力下进行。
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7.发明申请Modulators of the potassium channels twik-1, task-1 gorl1. sk2 pr pcn1, used to treat arrhythmia, coronary heat disease or hypertension 审中-公开钾通道调节剂twik-1，任务1 gorl1。 sk2 pr pcn1，用于治疗心律失常，冠心病或高血压公开(公告)号：US20060183665A1
公开(公告)日：2006-08-17
申请号：US10565185
申请日：2004-07-06
申请人： Peter Ellinghaus , Klaus Munter
发明人： Peter Ellinghaus , Klaus Munter
IPC分类号： A61K38/17
CPC分类号： C07K14/705 , A61K38/00
摘要： The invention relates to the use of modulators of the potassium channels TWIK-1, TASK-1, GIRK1 SK2 and PCN1 for producing a medicament for the treatment and/or prophylaxis of cardiac dysrhythmias (arrhythmias), coronary heart disease, and hypertension.
摘要翻译： 本发明涉及钾通道TWIK-1，TASK-1，GIRK1 SK2和PCN1的调节剂在制备用于治疗和/或预防心律失常（心律失常），冠心病和高血压的药物中的用途。
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公开(公告)号：US20060154912A1
公开(公告)日：2006-07-13
申请号：US10537623
申请日：2003-11-28
申请人： Michael Harter , Jens Erguden , Frank Wunder , Hanna Tinel , Johannes Kobberling , Eva-Maria Becker , Klaus Munter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Barfacker , Walter Hubsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
发明人： Michael Harter , Jens Erguden , Frank Wunder , Hanna Tinel , Johannes Kobberling , Eva-Maria Becker , Klaus Munter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Barfacker , Walter Hubsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
IPC分类号： A61K31/455 , A61K31/397 , A61K31/195 , A61K31/445
CPC分类号： C07D319/08 , C07C235/60 , C07C235/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D205/04 , C07D211/34 , C07D211/60 , C07D211/62 , C07D307/58 , C07D317/54 , C07D317/62 , C07D319/06 , C07D405/12
摘要： The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular of cardiovascular disorders.
摘要翻译： 本发明涉及间苯二甲酸衍生物，其制备方法及其用于制备用于治疗和/或预防人和动物特别是心血管疾病疾病的药物。
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