-
公开(公告)号：US11408004B2
公开(公告)日：2022-08-09
申请号：US14741164
申请日：2015-06-16
申请人： CuRNA, Inc.
IPC分类号： C12N15/11 , C12N15/113 , A61K31/7088
摘要： The present invention relates to antisense oligonucleotide that modulate the expression of and/or function of a Sirtuin (SIRT), in particular, by targeting natural antisense polynucleotides of a Sirtuin (SIRT). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Sirtuins (SIRT)s.
-
公开(公告)号：US10934546B2
公开(公告)日：2021-03-02
申请号：US16739266
申请日：2020-01-10
申请人： CuRNA, Inc.
IPC分类号： C12N15/11 , C12N15/113
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Sirtuin (SIRT), in particular, by targeting natural antisense polynucleotides of a Sirtuin (SIRT). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Sirtuins (SIRT)s.
-
公开(公告)号：US10435690B2
公开(公告)日：2019-10-08
申请号：US15847283
申请日：2017-12-19
申请人： CuRNA, Inc.
发明人： Joseph Collard , Olga Khorkova Sherman , Carlos Coito , Gang Shen
IPC分类号： C12N15/113 , A61K31/7088 , C12N15/10 , G01N33/53
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Alpha-L-Iduronidase (IDUA), in particular, by targeting natural antisense polynucleotides of Alpha-L-Iduronidase (IDUA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IDUA.
-
公开(公告)号：US10370657B2
公开(公告)日：2019-08-06
申请号：US15364050
申请日：2016-11-29
申请人： CuRNA, Inc.
IPC分类号： C12N15/113 , A61K31/713 , C07K14/78 , A61L27/36
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Collagen gene, in particular, by targeting natural antisense polynucleotides of a Collagen gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Collagen genes.
-
公开(公告)号：US10358646B2
公开(公告)日：2019-07-23
申请号：US14533371
申请日：2014-11-05
申请人： CuRNA, Inc.
IPC分类号： C12N15/11 , C12N15/113 , A61K31/712 , C12Q1/6886
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Tumor Suppressor genes, in particular, by targeting natural antisense polynucleotides of Tumor Suppressor genes. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Tumor Suppressor genes.
-
公开(公告)号：US10358645B2
公开(公告)日：2019-07-23
申请号：US15684587
申请日：2017-08-23
申请人： CuRNA, Inc.
IPC分类号： C12N15/113 , C07K14/505 , C12Q1/6883
摘要： Oligonucleotide compounds modulate expression and/or function of Erythropoietin (EPO) polynucleotides and encoded products thereof. Methods for treating diseases associated with Erythropoietin (EPO) comprise administering one or more oligonucleotide compounds designed to inhibit the EPO natural antisense transcript to patients.
-
公开(公告)号：US09834767B2
公开(公告)日：2017-12-05
申请号：US14582412
申请日：2014-12-24
申请人： CuRNA, Inc.
IPC分类号： C12N15/113 , A61K31/7088 , A61K31/712 , A61K31/7125 , C12Q1/68
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/113 , C12N2310/14 , C12Q1/6876 , C12Q2600/136 , C12Q2600/178
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Interferon Regulatory Factor 8 (IRF8), in particular, by targeting natural antisense polynucleotides of Interferon Regulatory Factor 8 (IRF8). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IRF8.
-
8.发明授权公开(公告)号：US09267136B2
公开(公告)日：2016-02-23
申请号：US14534323
申请日：2014-11-06
申请人： CuRNA, Inc.
IPC分类号： C07H21/04 , C12N15/113 , A61K31/7088 , C12Q1/68
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12Q1/6813
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Pancreatic Developmental gene, in particular, by targeting natural antisense polynucleotides of a Pancreatic Developmental gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Pancreatic Developmental genes.
摘要翻译： 本发明涉及调节胰腺发育基因表达和/或功能的反义寡核苷酸，特别是通过靶向胰腺发育基因的天然反义多核苷酸。 本发明还涉及这些反义寡核苷酸的鉴定及其在治疗与胰腺发育基因表达相关的疾病和病症中的用途。
-
9.发明授权Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene 有权通过抑制抗病毒基因的天然反义转录物治疗抗病毒基因相关疾病公开(公告)号：US09133456B2
公开(公告)日：2015-09-15
申请号：US14297101
申请日：2014-06-05
申请人： CuRNA, Inc.
IPC分类号： C07H21/02 , C07H21/04 , C12N15/113 , A61K31/7088
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/111 , C12N2310/113 , C12N2310/14 , C12N2310/315 , Y02A50/463
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an Antiviral gene, in particular, by targeting natural antisense polynucleotides of an Antiviral gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Antiviral genes.
摘要翻译： 本发明涉及通过靶向抗病毒基因的天然反义多核苷酸来调节抗病毒基因的表达和/或功能的反义寡核苷酸。 本发明还涉及这些反义寡核苷酸的鉴定及其在治疗与抗病毒基因表达相关的疾病和病症中的用途。
-
10.发明申请TREATMENT OF DISEASES RELATED TO ALPHA SUBUNITS OF SODIUM CHANNELS, VOLTAGE-GATED (SCNxA) WITH SMALL MOLECULES 审中-公开治疗与钠通道，具有小分子电压（SCNxA）的ALPHA亚基相关的疾病公开(公告)号：US20140309181A1
公开(公告)日：2014-10-16
申请号：US14343890
申请日：2012-08-28
申请人： CuRNA, Inc.
IPC分类号： A61K31/7048 , A61K31/4545 , A61K31/496 , A61K31/58 , A61K31/495 , A61K31/5513 , A61K31/436 , A61K31/5375 , A61K31/519 , A61K31/4985
摘要： Small compounds that modulate the expression of and/or function of sodium channel, voltage-gated, alpha subunit (SCNxA) are presented. Pharmaceutical compositions containing such small molecules and their use in treating diseases and disorders associated with the expression of SCNxA are also presented.
摘要翻译： 提出调节钠通道，电压门控α亚基（SCNxA）表达和/或功能的小化合物。 还提供了含有这种小分子的药物组合物及其在治疗与SCNxA表达相关的疾病和病症中的用途。
-
-
-
-
-
-
-
-
-
搜索结果
74 条记录 (耗时 0.047 秒)
