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公开(公告)号：US20080227982A1
公开(公告)日：2008-09-18
申请号：US12127467
申请日：2008-05-27
IPC分类号： C07D491/16
CPC分类号： C07D498/18
摘要： An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. The stability of the therapeutic agents may be improved by creating substantially solvent-free, amorphous forms of the therapeutic agents.
摘要翻译： 用于涂覆可植入医疗装置的改进方法利用许多技术来改善包含在涂层内的治疗剂的稳定性。 通过产生基本无溶剂的无定形形式的治疗剂可以改善治疗剂的稳定性。
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公开(公告)号：US07393952B2
公开(公告)日：2008-07-01
申请号：US11210393
申请日：2005-08-24
IPC分类号： C07D498/18
CPC分类号： C07D498/18
摘要： An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. The stability of the therapeutic agents may be improved by creating substantially solvent-free, amorphous forms of the therapeutic agents.
摘要翻译： 用于涂覆可植入医疗装置的改进方法利用许多技术来改善包含在涂层内的治疗剂的稳定性。 通过产生基本无溶剂的无定形形式的治疗剂可以改善治疗剂的稳定性。
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公开(公告)号：US07622145B2
公开(公告)日：2009-11-24
申请号：US11189189
申请日：2005-07-26
申请人： Eugena A. Akerman , Dirk Cleeren , Gerard Llanos , Cynthia A. Maryanoff , Georgios Papandreou , William Rion , Karel Six , Thomas L. Todd
发明人： Eugena A. Akerman , Dirk Cleeren , Gerard Llanos , Cynthia A. Maryanoff , Georgios Papandreou , William Rion , Karel Six , Thomas L. Todd
IPC分类号： A61L33/00
CPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/604 , A61L2420/08 , C08L65/04
摘要： Processes for coating implantable medical devices that improve the stability of therapeutic agents contained within the coating.
摘要翻译： 用于涂覆可植入医疗装置的方法，其改善包含在涂层内的治疗剂的稳定性。
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公开(公告)号：US06613914B2
公开(公告)日：2003-09-02
申请号：US10086583
申请日：2002-03-01
IPC分类号： C07D23112
CPC分类号： C07D231/12 , C07C51/083 , C07C59/88
摘要： A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
摘要翻译： 制备式I化合物的方法，其中取代基如说明书中所述包括使式II的酮与琥珀酸酐和醇盐碱反应形成式III化合物，其与式IV化合物反应形成 钒的化合物与醇反应以形成相应的式VI的酯，并使酯与N-甲基羟胺反应。
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5.发明授权Tramadol N-oxide material, enantiomers and compositions thereof, and their use 失效TRAMADOL氧化物材料，其成分及其组合物及其使用
公开(公告)号：US5223541A
公开(公告)日：1993-06-29
申请号：US759259
申请日：1991-09-13
IPC分类号： A61K31/14 , A61K31/135 , A61P1/12 , A61P11/14 , A61P25/04 , C07C291/04
CPC分类号： C07C291/04 , C07C2101/14 , Y10S514/85 , Y10S514/867
摘要： This invention relates to a tramadol N-oxide material, enantiomers and compositions thereof and their use. The tramadol N-oxide material and compositions thereof are pharmacologically useful in treating pain, diarrhea and tussive conditions. The tramadol N-oxide is also subject to less side-effects as compared to pure opiate based compositions, such as abuse liability, tolerance, constipation and respiratory depression. Furthermore, the tramadol N-oxide material when administered orally exhibits analgesia for a longer duration than an equi-analgesic amount of tramadol.
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公开(公告)号：US4781866A
公开(公告)日：1988-11-01
申请号：US934376
申请日：1986-11-24
IPC分类号： C07C381/14 , C07D207/26 , C07D207/273 , C07D295/215 , C07C139/00 , C07D239/10
CPC分类号： C07D207/273 , C07C381/14 , C07D295/215
摘要： An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): ##STR1## with H.sub.2 O.sub.2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.
摘要翻译： 喹啉的有效合成，例如 的式（III）化合物，通过氧化硫脲，例如 的下式（II）：用H 2 O 2和钼催化剂制备氨基亚氨基甲烷磺酸，然后可与胺反应，然后进行任选的转氨步骤。
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公开(公告)号：US4743400A
公开(公告)日：1988-05-10
申请号：US909794
申请日：1986-09-22
申请人： Cynthia A. Maryanoff
发明人： Cynthia A. Maryanoff
IPC分类号： C07C403/20 , A61K31/07 , C07C67/00 , C07C401/00 , C07C403/00 , C07C403/14 , C07C175/00
CPC分类号： C07C403/20 , C07C2101/16
摘要： A process to prepare retinoyl chlorides, e.g., of the following formula (I): ##STR1## under very mild chlorinating conditions by the action of a reagent amount of dimethylchloroformamidinium chloride on a corresponding retinoic acid.
摘要翻译： 在非常温和的氯化条件下，通过试剂量的二甲基氯代甲酰胺鎓对相应的视黄酸的作用，制备例如下式（I）的视黄酰氯的方法：（I）。
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公开(公告)号：US06610855B2
公开(公告)日：2003-08-26
申请号：US10197286
申请日：2002-07-15
申请人： Ahmed F. Abdel-Magid , Judith H. Cohen , Cynthia A. Maryanoff , Frank John Villani, Jr. , Hua M. Zhong
发明人： Ahmed F. Abdel-Magid , Judith H. Cohen , Cynthia A. Maryanoff , Frank John Villani, Jr. , Hua M. Zhong
IPC分类号： C07D21355
CPC分类号： C07C227/32 , C07B2200/07 , C07C229/34
摘要： A process for the synthesis of a compound of the formula wherein R1 is aryl, heteroaryl, substituted aryl or substituted heteroaryl and R2 is hydrogen, alkyl or aralkyl, or salt thereof.
摘要翻译： 用于合成糠醛的化合物R 1的方法是芳基，杂芳基，取代的芳基或取代的杂芳基，R 2是氢，烷基或芳烷基或其盐。
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9.发明授权
公开(公告)号：US5449677A
公开(公告)日：1995-09-12
申请号：US120015
申请日：1993-09-10
IPC分类号： C07D295/08 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4035 , A61K31/445 , A61K31/451 , A61K31/495 , A61P25/18 , A61P25/22 , C07D207/40 , C07D207/408 , C07D209/48 , C07D211/40 , C07D211/76 , C07D211/88 , C07D221/20 , C07D295/096 , C07D211/08 , C07D403/00
CPC分类号： C07D207/40 , C07D209/48 , C07D211/76 , C07D211/88 , C07D221/20 , C07D295/096
摘要： Compounds of the general formula I ##STR1## are disclosed as novel antipsychotic agents. Pharmaceutical compositions and methods of treating convulsions employing such compounds of formula I are also disclosed.
摘要翻译： 通式I的化合物作为新型抗精神病药被公开。 还公开了使用式I化合物治疗惊厥的药物组合物和方法。
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公开(公告)号：US4908450A
公开(公告)日：1990-03-13
申请号：US304304
申请日：1989-01-31
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A diastereoselective process for known antidepressive compounds (I) via reduction of the corresponding alcohol (VII): ##STR1## whereby the product mixture of diastereomers is surprisingly and unexpectedly rich in the content of the trans configuration (II) over the cis configuration (III) as defined in the following formulae: ##STR2## The preferred reaction conditions include use of a borane complex as the reducing agent and an acidic solvent such as trifuloroacetic acid.
摘要翻译： 通过还原相应的醇（VII），已知的抗抑郁化合物（I）的非对映选择性方法：其中非对映异构体的产物混合物出人意料地且意外地富含 （III）优选的反应条件包括使用硼烷配合物作为还原剂和酸性溶剂如 作为三氟乙酸。
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