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公开(公告)号：US20240083963A1
公开(公告)日：2024-03-14
申请号：US18352998
申请日：2023-07-14
Inventor： Sebastien Daniel Morisseau , Geraldine Teppaz , Yannick Laurent Joseph Jacques , Bruno Gilbert Marc Robert , Guy Luc Michel De Martynoff , David Béchard
IPC: C07K14/54 , A61K38/20 , C07K14/715 , C07K16/32
CPC classification number: C07K14/5443 , A61K38/2086 , C07K14/7155 , C07K16/32 , C07K16/2887
Abstract: The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an antibody or a fragment thereof directly or indirectly linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and (ii) a polypeptide comprising the amino acid sequence of the sushi domain of the interleukin 15R alpha (IL-15Rα) or derivatives thereof; and uses thereof.
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2.发明公开
公开(公告)号：US20240350589A1
公开(公告)日：2024-10-24
申请号：US18683180
申请日：2022-08-16
Applicant: Cytune Pharma
Inventor： Lenka Kyrych Sadilkova , Ulrich Moebius , David Béchard , Irena Adkins
CPC classification number: A61K38/2086 , A61K9/0019 , A61K38/1793 , A61K45/06 , A61K47/6855 , A61P35/00 , C07K16/2818 , C07K16/2827
Abstract: The invention relates to an interleukin-2/interleukin-receptor βγ(IL-2/IL-15Rβγ) agonist for use in treating cancer in a patient, wherein said IL-2/IL-15Rβγ agonist is administered in combination with a cytotoxic compound capable of inducing immunogenic cell death (TCD) or in combination with an application of a modality capable of inducing TCD.
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公开(公告)号：US20240294594A1
公开(公告)日：2024-09-05
申请号：US18573397
申请日：2022-06-23
Applicant: Cytune Pharma , Sotio Biotech a.s.
Inventor： Irena Adkins , Eva Nedvedová , Guy Luc Michel De Martynoff , Ulrich Moebius , David Béchard , Šárka Pechoucková , Zuzana Antošová , Lenka Kyrych Sadilkova , Roger Renzo Beerli , Lukas Bammert , Lorenz Waldmeier , Iva Valentová , Simona Hošková
IPC: C07K14/54 , A61K39/00 , C07K14/715 , C07K16/28
CPC classification number: C07K14/5443 , C07K14/7155 , C07K16/28 , C07K16/2818 , C07K16/2887 , A61K2039/505 , C07K2317/24 , C07K2317/40 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30 , C07K2319/32
Abstract: The present invention inter alia relates to immunocytokines involving IL-15 superagonists (based on IL-15 and the sushi domain of IL-15Rα) and an antibody. The invention also provides nucleic acids, vectors, methods and medical uses.
