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公开(公告)号：US10968169B2
公开(公告)日：2021-04-06
申请号：US16339305
申请日：2017-10-05
IPC分类号： C07C275/42 , C07C323/44 , C07D207/10 , C07D211/06 , C07D333/36
摘要： An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect, and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in the blood. The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound represented by the following formula, or a pharmacologically acceptable salt thereof: wherein R1 and R2 are the same or different, and represent a C1-C6 alkyl group or the like, and Ar represents an optionally substituted phenyl group or an optionally substituted thienyl group.
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公开(公告)号：US10925848B2
公开(公告)日：2021-02-23
申请号：US16487401
申请日：2018-02-20
发明人： Tsuyoshi Soneda , Hiroki Sakai , Koji Matsumoto , Naomi Tanaka , Taichi Fukunaga
IPC分类号： A61P43/00 , A61P13/12 , A61K31/198 , A61K31/277 , C07C237/36 , C07C237/44
摘要： An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect, and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in the blood. Provided is a pharmaceutical composition containing, as an active ingredient, a compound represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula (I), R1 and R2 are the same or different, and represent a C1-C6 alkyl group, a halogeno C1-C6 alkyl group or a C3-C6 cycloalkyl group; n represents 0, 1 or 2; each X represents a C1-C6 alkyl group, a C3-C6 cycloalkyl group, a halogen atom or the like; and Y represents a hydrogen atom, a C1-C6 alkoxy group, a C3-C6 cycloalkoxy group or a halogeno C1-C6 alkoxy group.
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公开(公告)号：US20200017439A1
公开(公告)日：2020-01-16
申请号：US16339305
申请日：2017-10-05
IPC分类号： C07C275/42 , C07C323/44 , C07D333/36 , C07D211/06 , C07D207/10
摘要： An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect, and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in the blood. The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound represented by the following formula, or a pharmacologically acceptable salt thereof: wherein R1 and R2 are the same or different, and represent a C1-C6 alkyl group or the like, and Ar represents an optionally substituted phenyl group or an optionally substituted thienyl group.
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4.发明申请公开(公告)号：US20180311278A1
公开(公告)日：2018-11-01
申请号：US15770917
申请日：2016-10-25
发明人： Koji Matsumoto , Tomomi Yoshitomi , Naomi Tanaka , Kazuhiro Yoshida , Yuji Kasuya , Masaoki Ohya
摘要： The problem with which the present invention is concerned is providing a novel pharmaceutical preparation, the restrictions on the administration of which to a patient are more relaxed than those of a conventional spherical carbon adsorbent, which can be simultaneously taken with other drugs and, moreover, which is reduced in dosage. The problem can be solved by a pharmaceutical preparation for oral administration comprising a porous material, wherein a means for exposing a surface of the porous material for the first time in the large intestine or a lower part of the small intestine is provided on the porous material.
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公开(公告)号：US09725438B2
公开(公告)日：2017-08-08
申请号：US14956240
申请日：2015-12-01
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D413/12 , C07D417/12 , C07D249/06 , C07D257/04 , C07D263/32 , C07D271/06 , C07D277/20 , C07D277/30 , A61K31/421 , A61K31/4439
CPC分类号： C07D403/12 , A61K31/421 , A61K31/4439 , C07D249/06 , C07D257/04 , C07D263/32 , C07D271/06 , C07D277/20 , C07D277/30 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12
摘要： Compounds are provided having an excellent hypoglycemic effect and β cell- or pancreas-protecting effects, or pharmaceutically acceptable salts thereof, and a pharmaceutical composition having an excellent therapeutic effect and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause hyperglycemia due to abnormal glucose metabolism. A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, is disclosed.
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公开(公告)号：US09233958B2
公开(公告)日：2016-01-12
申请号：US14372832
申请日：2013-01-17
IPC分类号： C07D417/12 , C07D403/12 , C07D401/14 , C07D401/12 , C07D413/12 , C07D249/06 , C07D257/04 , C07D263/32 , C07D271/06 , C07D277/20 , C07D277/30
CPC分类号： C07D403/12 , A61K31/421 , A61K31/4439 , C07D249/06 , C07D257/04 , C07D263/32 , C07D271/06 , C07D277/20 , C07D277/30 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12
摘要： Compounds are provided having an excellent hypoglycemic effect and β cell- or pancreas-protecting effects, or pharmaceutically acceptable salts thereof, and a pharmaceutical composition having an excellent therapeutic effect and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause hyperglycemia due to abnormal glucose metabolism. A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, is disclosed.
摘要翻译： 提供具有优异的降血糖作用的化合物和 细胞或胰腺保护作用，或其药学上可接受的盐，以及由于葡萄糖代谢异常引起高血糖的1型糖尿病，2型糖尿病等具有优异的治疗效果和/或预防效果的药物组合物。 公开了由通式（I）表示的化合物或其药学上可接受的盐。
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公开(公告)号：US20220144765A1
公开(公告)日：2022-05-12
申请号：US17585381
申请日：2022-01-26
IPC分类号： C07C275/42 , C07C323/44 , C07D207/10 , C07D211/06 , C07D333/36
摘要： An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in the blood. The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound represented by the following formula, or a pharmacologically acceptable salt thereof: wherein R1 and R2 are the same or different, and represent a C1-C6 alkyl group or the like, and Ar represents an optionally substituted phenyl group or an optionally substituted thienyl group.
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公开(公告)号：US20210206716A1
公开(公告)日：2021-07-08
申请号：US17210215
申请日：2021-03-23
IPC分类号： C07C275/42 , C07C323/44 , C07D207/10 , C07D211/06 , C07D333/36
摘要： An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in the blood. The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound represented by the following formula, or a pharmacologically acceptable salt thereof: wherein R1 and R2 are the same or different, and represent a C1-C6 alkyl group or the like, and Ar represents an optionally substituted phenyl group or an optionally substituted thienyl group.
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公开(公告)号：US20140357675A1
公开(公告)日：2014-12-04
申请号：US14372832
申请日：2013-01-17
IPC分类号： C07D417/12 , C07D249/06 , C07D401/12 , C07D277/30 , C07D401/14 , C07D403/12
CPC分类号： C07D403/12 , A61K31/421 , A61K31/4439 , C07D249/06 , C07D257/04 , C07D263/32 , C07D271/06 , C07D277/20 , C07D277/30 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12
摘要： Compounds are provided having an excellent hypoglycemic effect and β cell- or pancreas-protecting effects, or pharmaceutically acceptable salts thereof, and a pharmaceutical composition having an excellent therapeutic effect and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause hyperglycemia due to abnormal glucose metabolism. A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, is disclosed.
摘要翻译： 提供具有优异的降血糖作用的化合物和 细胞或胰腺保护作用，或其药学上可接受的盐，以及由于葡萄糖代谢异常引起高血糖的1型糖尿病，2型糖尿病等具有优异的治疗效果和/或预防效果的药物组合物。 公开了由通式（I）表示的化合物或其药学上可接受的盐。
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