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公开(公告)号：US09725438B2
公开(公告)日：2017-08-08
申请号：US14956240
申请日：2015-12-01
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D413/12 , C07D417/12 , C07D249/06 , C07D257/04 , C07D263/32 , C07D271/06 , C07D277/20 , C07D277/30 , A61K31/421 , A61K31/4439
CPC分类号： C07D403/12 , A61K31/421 , A61K31/4439 , C07D249/06 , C07D257/04 , C07D263/32 , C07D271/06 , C07D277/20 , C07D277/30 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12
摘要： Compounds are provided having an excellent hypoglycemic effect and β cell- or pancreas-protecting effects, or pharmaceutically acceptable salts thereof, and a pharmaceutical composition having an excellent therapeutic effect and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause hyperglycemia due to abnormal glucose metabolism. A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, is disclosed.
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公开(公告)号：US09233958B2
公开(公告)日：2016-01-12
申请号：US14372832
申请日：2013-01-17
IPC分类号： C07D417/12 , C07D403/12 , C07D401/14 , C07D401/12 , C07D413/12 , C07D249/06 , C07D257/04 , C07D263/32 , C07D271/06 , C07D277/20 , C07D277/30
CPC分类号： C07D403/12 , A61K31/421 , A61K31/4439 , C07D249/06 , C07D257/04 , C07D263/32 , C07D271/06 , C07D277/20 , C07D277/30 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12
摘要： Compounds are provided having an excellent hypoglycemic effect and β cell- or pancreas-protecting effects, or pharmaceutically acceptable salts thereof, and a pharmaceutical composition having an excellent therapeutic effect and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause hyperglycemia due to abnormal glucose metabolism. A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, is disclosed.
摘要翻译： 提供具有优异的降血糖作用的化合物和 细胞或胰腺保护作用，或其药学上可接受的盐，以及由于葡萄糖代谢异常引起高血糖的1型糖尿病，2型糖尿病等具有优异的治疗效果和/或预防效果的药物组合物。 公开了由通式（I）表示的化合物或其药学上可接受的盐。
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公开(公告)号：US20140357675A1
公开(公告)日：2014-12-04
申请号：US14372832
申请日：2013-01-17
IPC分类号： C07D417/12 , C07D249/06 , C07D401/12 , C07D277/30 , C07D401/14 , C07D403/12
CPC分类号： C07D403/12 , A61K31/421 , A61K31/4439 , C07D249/06 , C07D257/04 , C07D263/32 , C07D271/06 , C07D277/20 , C07D277/30 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12
摘要： Compounds are provided having an excellent hypoglycemic effect and β cell- or pancreas-protecting effects, or pharmaceutically acceptable salts thereof, and a pharmaceutical composition having an excellent therapeutic effect and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause hyperglycemia due to abnormal glucose metabolism. A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, is disclosed.
摘要翻译： 提供具有优异的降血糖作用的化合物和 细胞或胰腺保护作用，或其药学上可接受的盐，以及由于葡萄糖代谢异常引起高血糖的1型糖尿病，2型糖尿病等具有优异的治疗效果和/或预防效果的药物组合物。 公开了由通式（I）表示的化合物或其药学上可接受的盐。
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公开(公告)号：US08975263B2
公开(公告)日：2015-03-10
申请号：US14291860
申请日：2014-05-30
发明人： Shigeo Yamanoi , Katsuji Kagechika , Tsuyoshi Soneda , Yuichi Ochiai , Hidenori Namiki , Fuminao Doi , Madoka Hoshino , Shoko Yoshida
IPC分类号： C07D405/10 , C07D405/14 , C07D413/14
CPC分类号： C07D405/10 , C07D405/14 , C07D413/14
摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent glucose lowering effect.A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: wherein R1 represents a C1-C3 alkyl group, each substituent R2 may be the same or different and may each represent a C1-C3 alkyl group, R3 represents an optionally substituted pyridyl group or the like, R4 and R5, which are the same or different, each represent a C1-C3 alkyl group, R6 and R7, which are the same or different, each represent a C1-C3 alkyl group, and n represents 0 to 3.
摘要翻译： 本发明涉及具有优异葡萄糖降低作用的化合物或其药理学上可接受的盐。 由以下通式（I）表示的化合物或其药学上可接受的盐：其中R1表示C1-C3烷基，各取代基R2可以相同或不同，可各自表示C1-C3烷基，R3表示 任选取代的吡啶基等，R 4和R 5相同或不同，各自表示C1-C3烷基，R6和R7相同或不同，分别表示C1-C3烷基，和 n表示0〜3。
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