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公开(公告)号：US20200346033A1
公开(公告)日：2020-11-05
申请号：US16870665
申请日：2020-05-08
Applicant: DALHOUSIE UNIVERSITY
Inventor： Robert Lee MACDONALD , Alasdair SYME , Christopher G. THOMAS
IPC: A61N5/10
Abstract: Generating a plan for radiation treatment of multiple target volumes such as, for example, multiple brain tumors, involves optimizing a grouping of the target volumes into subsets and generating treatment plans for each subset. Resulting treatment plans may minimize radiation dose to tissues outside of the target volumes. A radiation treatment planning system may be configured to operate in this manner and to upload control signals which cause a radiation therapy device such as a linear accelerator to execute the radiation treatment plans.
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公开(公告)号：US20200164227A1
公开(公告)日：2020-05-28
申请号：US16615074
申请日：2018-05-24
Applicant: Dalhousie University
Inventor： Robert Lee MACDONALD , Alasdair SYME , Christopher G. THOMAS
IPC: A61N5/10
Abstract: A radiation treatment planning system and method for generating plans to treat plural target volumes, each associated with a prescribed dose, does not require delivery of radiation to every target volume from every beam direction. Allowing target volumes to be omitted for some control points facilitates generation of treatment plans that deliver less radiation dose to non-target tissues by allowing beam shaping to more closely fit the remaining target volumes. Simulated annealing using an objective function may be applied to determine parameters such as the number of control points for which a target volume is not targeted.
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3.发明申请
公开(公告)号：US20190030372A1
公开(公告)日：2019-01-31
申请号：US16083454
申请日：2017-03-09
Applicant: DALHOUSIE UNIVERSITY
Inventor： Robert Lee MACDONALD , Alasdair SYME , Christopher G. THOMAS
IPC: A61N5/10
Abstract: Systems and methods are provided for determining an angular trajectory for dynamically rotating a multileaf collimator during arc therapy. According to various embodiments, a suitable collimator trajectory may be determined based on the reduction or minimization of a residual unblocked area residing between a planning target volume and leaves of the multileaf collimator in the beam's eye view over the set of control points corresponding to an arc therapy plan. Various example methods are provided for determining collimator trajectories based on whitespace reduction, and for providing quantitative measures of whitespace optimization associated with a given trajectory. In some embodiments, the whitespace may be calculated using terms that account for the overlap of a planning target volume with an organ at risk of exposure.
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公开(公告)号：US20210244970A1
公开(公告)日：2021-08-12
申请号：US17054141
申请日：2019-04-18
Applicant: DALHOUSIE UNIVERSITY
Inventor： Robert Lee MACDONALD , Alasdair SYME , Christopher G. THOMAS , Brian LITTLE
Abstract: Methods and systems for radiation treatment planning and delivery apply a CODA cube. Cost values in the CODA cube may be used in the optimization of couch, collimator, and gantry angles simultaneously. Trajectories generated using the CODA cube show significant benefits when compared to conventional VMAT. A statistically significant sparing to OAR maximum radiation doses was seen. CODA plans resulted in a reduction to maximum radiation dose in OARs of 20.6% (p
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公开(公告)号：US20190162863A1
公开(公告)日：2019-05-30
申请号：US16092246
申请日：2017-04-13
Applicant: DALHOUSIE UNIVERSITY
Inventor： Alasdair SYME , Ian HILL
CPC classification number: G01T1/026 , G01T1/02 , H01L51/0512 , H01L51/44
Abstract: Radiation dosimeters are disclosed whereby a passive multilayer substrate is provided to confer tissue equivalence. In an example embodiment, a multilayer substrate is formed over a semiconductor-based radiation sensing layer, where the multilayer substrate includes at least one low-atomic-number layer of having an effective atomic number that is smaller than that of water, and at least one high-atomic-number layer having an effective atomic number that is greater than that of water. The low-atomic-number layers and high-atomic-number layers are provided with respective thicknesses and compositions for modulating the dependence of the signal produced by the radiation dosimeter on photon energy, such that the signal, when calibrated to provide a measure of dose, exhibits approximate tissue-equivalence over a prescribed photon energy range. The multilayer substrate may be configured such that tissue equivalence is provided over an energy range including diagnostic and therapeutic energy ranges, spanning, for example, 20 keV to 5 MeV.
